Warianty tytułu
Języki publikacji
Abstrakty
The study aimed at demonstration of involvement of CD8+ cells in protective mechanisms in canine mammary gland carcinomas. Material for the studies involved metastases to lungs sampled at autopsy from crossbreed bitches aged 11 to 13 years. The tumours were verified histopathologically as adenocarcinomas. The presence of CD8+ cells infiltrating the examined tumour tissues was estimated in cryo-sections by immunofluorescence methods. Parental tumours free of metastases were accompanied by slight infiltration of CD8+ cells. In the case of metastasing tumours, and especially in their pulmonary metastases, the increased number of CD8+ cells was observed. Taken together, metastasing potential of canine mammary adenocarcinomas was positively correlated with the number of CD8+ cells in the tumour stroma.
Wydawca
Rocznik
Tom
Numer
Opis fizyczny
p.445-448,fig.,ref.
Twórcy
autor
- University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
autor
autor
autor
Bibliografia
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- 2. Bilik R., Mor C., Hazaz B., Moroz C.: Characterization of T-lymphocyte subpopulations infiltrating primary breast cancer. Cancer Immunol Immunother 1989, 28, 143-147.
- 3. Chin Y., Janseens J., Vandepitte J., Vandenbrande J., Opdebeek L., Raus J.: Phenotypic analysis of tumor-infiltrating lymphocytes from human breast cancer. Anticancer Res 1992, 12, 1463-1466.
- 4. Gołąb J., Jakóbisiak M., Lasek W.: Immunology. PWN, Warszawa, 2002.
- 5. Kruś S., Skrzypek-Fakhoury E.: Clinical Pathomorphology. PZWL, Warszawa, 1996.
- 6. Mohamadzadeh M., Berard F., Essert G., Chalouni C., Pulendran B., Palucka K., Banchereau J.: Interleukin IL-15 skews monocyte differentation into dendritic cells with features of Langerhans cells. J Exp Med 2001, 194, 1013-1020.
- 7. Roitt I., Brostoff J., Male D.: Immunology. PZWL, Warszawa, Ed. Słowiński Verlag, Brema, 2000.
- 8. Sheu B.C., Hsu S.M., Ho H.N., Lin R.H., Torng P.L., Huang S.C.: Reversed CD4/CD8 ratios of tumor-infiltrating lymphocytes are correlated with the progression of human cervical carcinoma. Cancer 1999, 86, 1537-1543.
- 9. Snyderman C.H., Heo D.S., Chen K., Whiteside T.L., Johnson J.T.: T-cell markers in tumor-infiltrating lymphocytes of head and neck cancer. Head Neck 1989, 11, 331-336.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-article-fe37c9b7-1ea5-4369-9439-1642bf0f08ad