An introduction to DNA chips: principles, technology, applications and analysis

• Autorzy: Gabig M. , Wegrzyn G.
• Języki publikacji: EN

Abstrakty

EN

This review describes the recently developed GeneChip technology that provides ef­ficient access to genetic information using miniaturised, high-density arrays of DNA or oligonucleotide probes. Such microarrays are powerful tools to study the molecular basis of interactions on a scale that would be impossible using conventional analysis. The recent development of the microarray technology has greatly accelerated the in­vestigation of gene regulation. Arrays are mostly used to identify which genes are turned on or off in a cell or tissue, and also to evaluate the extent of a gene's expres­sion under various conditions. Indeed, this technology has been successfully applied to investigate simultaneous expression of many thousands of genes and to the detec­tion of mutations or polymorphisms, as well as for their mapping and sequencing.

Słowa kluczowe

EN

polymorphism; gene; GeneChip technology; hybridization; gene expression; DNA array; mutation; DNA chip; detection; genetic information; oligonucleotide

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 3
• Opis fizyczny: p.615-622,fig.

Twórcy

autor

Gabig M.

• Royal Institute of Technology, S-10691 Stockholm, Sweden

autor

Wegrzyn G.

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