Effect to tetrazole moiety on coordinating efficiency of deltorphin

• Autorzy: Lodyga-Chruscinska E. , Oldziej S. , Micera G. , Sanna D. , Chruscinski L. , Olczak J. , Zabrocki J.
• Języki publikacji: EN

Abstrakty

EN

A study of the effect of the tetrazole moiety, a cis-amide bond surrogate, on the Cu(II) coordinating properties of oligopeptides is reported. Insertion of the tetrazole moiety Ψ[CN4] into the peptide sequence of [D-Ala2]deltorphin I changes considerably the coordination ability of the peptide. Potentiometric and spectroscopic results show that if the tetrazole moiety is in a suitable position in the peptide chain, i.e. It follows the second residue, a stable CuL species involving 3N coordination is formed in the physiological pH range. The tetrazole Ψ[CN4] ring provides one of these nitrogens. The data indicate that Cu(II) ions are strongly trapped inside a bent peptide backbone. The peptide conformation changes achieved by Cu(II) coordination may be essential for the binding of tetrazole deltorphins at opiate receptors.

Słowa kluczowe

EN

tetrazole moiety; opioid peptide; deltorphin; peptide; tetrazole analogue; coordinating efficiency

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2004
• Tom: 51
• Numer: 1
• Opis fizyczny: p.93-106,fig.,ref.

Twórcy

autor

Lodyga-Chruscinska E.

• Technical University of Lodz, Stefanowskiego 4-10, 90-924 Lodz, Poland

autor

Oldziej S.

autor

Micera G.

autor

Sanna D.

autor

Chruscinski L.

autor

Olczak J.

autor

Zabrocki J.

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