Czasopismo
Tytuł artykułu
Warianty tytułu
Effect of vetahapar on bile secretion in sheep
Języki publikacji
Abstrakty
The effect of Vetahepar (VH) (active ingredient: menbutone), given per os (p.o.) or i.v., on volume and biliary bile salt secretion was investigated on four sheep, which were cannulated for choledochus and duodenum. The dose of VH 20 mg/kg m.c. given p.o. was most effective in the stimulation of bile salts secretion and volume of bile. The choleretic effects of VH began 30 minutes after oral administration and peaked at 60 minutes. The augmented volume of bile occurred earlier than the increase in bile salt secretion. Such a response can suggest that the relaxation of the vascular bed in the liver under the influence of VH stimulation anticipates events evoked by bile salt stimulation. Furthermore, a considerably higher response to the same dose of VH has been observed when only 50% of the bile returned to the duodenum. Thus beneficial effects of VH are especially revealed when disturbances in liver functioning occur.
Słowa kluczowe
Wydawca
Czasopismo
Rocznik
Tom
Numer
Strony
979-981
Opis fizyczny
s.979-981,rys.,tab.,bibliogr.
Twórcy
autor
- Akademia Rolnicza w Lublinie, ul.Akademicka 12, 20-033 Lublin
autor
autor
autor
autor
Bibliografia
- 1.Aazer S. A., Murray M., Farrell G. C., Stacey N. H.: Selectivity and sensitivity of changes in serum bile acids during induction of cirrhosis in rats. Hepatology 1993, 5, 1224-1231.
- 2.Bobowiec R., Kosior-Korzecka U.: Relationships amongst liver bile salt clearance, bile secrection and infusion of lipids in calves. J. Vet. Med. 1999, 46, 409-420.
- 3.Bobowiec R., Martelli F., Sighieri C., Borowicz P.: Gallbladder pressure changes induced by caerulein, pilocarpine and bile salt in calves measured by radiotelemetry. Polish J. Vet. Sci. 2000, 3, 147-152.
- 4.Eder M. I., Miquel F. J., Jüngst D., Paumgartner G., von Ritter C.: Reactive oxygen metabolites promote cholesterol crystal formation in model bile: pole of lipid peroxydation. Free Radical Biol.&Med. 1996, 20, 743-749.
- 5.Garwacki S., Dąbrowski J., Dutkiewicz M.: Effect of carbachol and atropine on bile secrection in sheep. Pol. Arch. Vet. 1998, 28, 71-77.
- 6.Hassan A. S., Garwacki S., Dutkiewicz M., Dąbrowski J.: The changes of bile flow and its composition in sheep following liver damage by carbon tetrachloride. Pol. Arch.Vet. 1992, 32, 1-99.
- 7.Hofman A. F.: Targeting drugs to the enterohepatic circulation: lessons from bile acids and other endobiotics. J. Con. Rel. 1985, 2, 3-11.
- 8.Kaur B., Ahuja S. P.: Charakterization of billiary proteins and composition of bile from sheep and goats. Zntbl. Vet. A 1993, 40, 598-604.
- 9.Lammert F., Marschall H.-U., Glantz A., Matern S.: Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management. J. Hepatology 2000, 33, 1012-1021.
- 10.Roland P. J., Oude E., Dirk K. F., Kuipers F., Jansen P. L. M., Groen A. K., Groothuis G. M. M.: Hepatobilliary secrection of organic compounds; molecular mechanism of membrane transport. Bioch. Bioph. Acta 1995, 1241, 215-268.
- 11.Studziński T., Bobowiec R.: Wpływ sekretyny i chemicznej stymulacji dwunastnicy na funkcje neutralizacyjne soku trzustkowego i żółci u owiec. Medycyna Wet. 1979, 35, 443-447.
- 12.Symonds H. W.: The choleretic effect of menbutone and clanobutin sodium in steers. Vet. Rec.1982, 110, 423-425.
- 13.Verkade H. J., Vonk R. J., Kupiers F.: New insight into the mechanism of bile acid-induced billiary lipid secrection. Hepatology 1995, 21, 1174-1183.
- 14.West H. J.: Evaluation of total serum bile acid concetrations for the diagnosis hepatobiliary disease in cattle. Res. Vet. Sci. 1991, 51, 133-140.
- 15.Wójcik M., Bobowiec R., Martelli F., Gazzano A.: The response of bile secrection and ubiquinone Q10 to hyperglycaemia in sheep. Polish J. Vet. Sci. 2003, 6, 183-188.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-article-f25f5d56-6e00-4a60-858e-1ce1614c2160