Fragments of LINE-1 retrotransposons flanked by inverted telomeric repeats are present in the bovine genome. Homology with human LINE-1 elements

• Autorzy: Plucienniczak G. , Plucienniczak A.
• Języki publikacji: EN

Abstrakty

EN

In the bovine genome we found two intrachromosomal DNA fragments flanked by inverted telomeric repeats (GenBank Accession Nos. AF136741 and AF136742). The internal parts of the fragments are homologous exclusively to the human sequences and to the consensus sequence of the L1MC4 subfamily of LINE-1 retrotransposons which are widespread among mammalian genomes. We found that distribution of homologous human sequences within our fragments is not random, reflecting a complicated pattern of insertion mechanisms of and maintenance of retrotransposons in mammalian genomes. One of the possible explanations of the origin of LINE-1 truncated elements flanked by inverted telomeric repeats in the bovine genome is that extrachromosomal DNA fragments may be modified by telomerase and subsequently, transferred into chromosomal DNA.

Słowa kluczowe

EN

telomerase; extrachromosomal element; mammalian chromosome; bovine genome; mammal genome; telomere; telomeric sequence; modification

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1999
• Tom: 46
• Numer: 4
• Opis fizyczny: p.873-878,fig.

Twórcy

autor

Plucienniczak G.

• Institute of Biotechnology and Antibiotics, Staroscinska 5, 02-516 Warsaw, Poland

autor

Plucienniczak A.

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