Coordination chemistry of glutathione

• Autorzy: Krezel A. , Bal W.
• Języki publikacji: EN

Abstrakty

EN

The metal ion coordination abilities of reduced and oxidized glutathione are reviewed. Reduced glutathione (GSH) is a very versatile ligand, forming stable complexes with both hard and soft metal ions. Several general binding modes of GSH are described. Soft metal ions coordinate exclusively or primarily through thiol sulfur. Hard ones prefer the amino acid-like moiety of the glutamic acid residue. Several transition metal ions can additionally coordinate to the peptide nitrogen of the γ-Glu-Cys bond. Oxidized glutathione lacks the thiol function. Nevertheless, it proves to be a surprisingly efficient ligand for a range of metal ions, coordinating them primarily through the donors of the glutamic acid residue.

Słowa kluczowe

EN

stability constant; glutamic acid; human cell; glutathione; non-protein tripeptide; peptide nitrogen; physiological function; metal ion complex

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1999
• Tom: 46
• Numer: 3
• Opis fizyczny: p.567-580,fig.

Twórcy

autor

Krezel A.

• University of Wroclaw, F.Joliot-Curie 14, 50-383 Wroclaw, Poland

autor

Bal W.

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