Evidence for the presence of different alpha-1-proteinase inhibitor genes products in mouse plasma

• Autorzy: Dubin A. , Mak P. , Travis J.
• Języki publikacji: EN

Abstrakty

EN

The plasma alpha-l-proteinase inhibitor (API) of three mouse species Mus domes- ticus, M. caroli and M. pahori was isolated. Each of the species isoforms were then separated by chromatofocusing; however, no significant differences in association rate constants toward human neutrophil elastase and bovine chymotrypsin were observed. The amino-acid sequence of the P'i-P'15 C-terminal fragments of the API variants indicate that mouse plasma contains at least two different active API isoforms in the case of M. domesticus (five API genes) but only one active API isoform in M. pahori and M. caroli (one API gene).

Słowa kluczowe

EN

Mus caroli; alpha-1-proteinase inhibitor; Mus domesticus; mice; serpin; mouse plasma; multigene family transcription; Mus pahori; neutrophil elastase; alpha-1-antitrypsin

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1996
• Tom: 43
• Numer: 3
• Opis fizyczny: p.475-479,fig.

Twórcy

autor

Dubin A.

• Jagiellonian University, al.A.Mickiewicza 3, 31-120 Krakow, Poland

autor

Mak P.

autor

Travis J.

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