Prediction of protein secondary structure by neural networks: encoding short and long range patterns of amino acid packing

• Autorzy: Vieth M. , Kolinski A. , Skolnick J. , Sikorski A.
• Języki publikacji: EN

Abstrakty

EN

À complex, cascaded neural network designed to predict the secon­dary structure of globular proteins has been developed. Information about the local buried-unburied pattern and the average tendency of the particular types of amino acids to be buried inside the globule were used. Nonspecific information about long distance contact maps was also employed. These modifications result in a noticeable improvement (3 - 9%) of prediction accuracy. The best result for the average success ratio for the testing set of nonhomologous proteins was 68.3% (with corresponding Matthews' coefficients, C

Słowa kluczowe

EN

protein; amino acid; neural network

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1992
• Tom: 39
• Numer: 4
• Opis fizyczny: p.369-392,fig.

Twórcy

autor

Vieth M.

• The Scripps Research Institute, La Jolla, California 92037, USA

autor

Kolinski A.

autor

Skolnick J.

autor

Sikorski A.

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