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Abstrakty
Podjęto próbę określenia nefrotoksyczności bromobenzenu po wielokrotnym podaniu, wykorzystując wybrane wskaźniki biochemiczne.
The aim of this study was to determine the effect of bromobenzene (BB), administered to rats in repeated doses (from 7 up to 28 days), on selected indicators of nephrotoxicity. In our experiments, slight decrease (by 10-40%) in diurnal urine output and the increase in GSH concentration in kidneys (most visible after 7 days) was detected. The number of renal epithelial cells, which was elevated 2-3 fold and the concentration of urinary proteins, which increased up to 160% of the control values, turned out to be the most sensitive indicators. The changes in both of these indicators may reflect slight impairment of the renal tubules and glomeruli. In comparison with single administration of the BB in high dose, prolonged exposure did not result in the intensification of nephrotoxic effect of this compound.
Wydawca
Czasopismo
Rocznik
Tom
Numer
Strony
167-172
Opis fizyczny
s.167-172,tab.,wykr.,bibliogr.
Twórcy
Bibliografia
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- 2. Reid W.D., Christie B., Krishna G., Mitchell J.R., Moskowitz J., Brodie B.B.: Bromobenzene metabolism and hepatic necrosis, Pharmacology, 1971; 6: 41-55
- 3. Zampaglione N., Jollow D.J., Mitchell JR., Stripp B., Hamrick M., Gillette J.R. : Role of detoxifying enzymes in bromobenzene - induced liver necrosis, J. Pharmacol. Exp. Ther., 1973; 187: 218-223
- 4. Lau S.S., Monks T.J., Gillette J.R.: Identification of 2-bromohydroquinone as a metabolite of bromobenzene and o-bromophenol: implications for bromobenzene - induced nephrotoxicity, J. Pharm. Exp. Ther., 1984; 230 (2): 360-366
- 5. Lau S.S., Greene K.E., Gillette J.R.: The role of ortho-bromophenol in the nephrotoxicity of bromobenzene in rats, Toxicol. Appl. Pharmacol., 1984; 72: 539-549
- 6. Lertranangkoon K., Homing E C., Homing N.G.: Pathways of formation of 2-, 3- and 4-bromophenol from bromobenzene, Res. Comm. Chem. Pathol. Pharmacol., 1993; 80 (3): 259-282
- 7. Parke D.V., Piotrowski J.K.: Glutathione: Its role in the detoxication of reactive oxygen and environmental chemicals, Acta Polon. Toxicol., 1996; 4 (1): 1-13
- 8. Monks T.J., Lau S.S.: Glutathione, y-glutamyltranspeptidase, and the mercapturic acid pathway, as modulators of 2-bromohydroquinone oxidation, Toxicol. Appl. Pharmacol., 1990; 103: 557-563
- 9. Deichman K., Le Blanek W.B.: Determination of the approximate lethal dose with about six animals, J. Ind. Hyg. Toxicol., 1943; 25: 415-420
- 10. Sedlak I., Lindsay R.H.: Estimation of total protein bound, and nonprotein sulfhydryl groups in tissue with Ellmann's reagent, Anal. Bioch., 1968; 25: 192-205
- 11. Richterich R.: Chemia kliniczna, PZWL, Warszawa, 1971; 256-258
- 12. Tomaszewski L.: Mikrometody biochemiczne w laboratorium klinicznym, PZWL, Warszawa, 1970; 143-147
- 13. Angielski S.: Biochemia kliniczna i analityka, PZWL, Warszawa, 1985; 570-573
- 14. Balazs T., Hatch A., Zawidzka Z, Grice H.C.: Renal tests in toxicology studies on rats, Toxicol. Appl. Pharmacol., 1963; 5: 661-674
- 15. Sunderman F.W., Horak E.: Biochemical indices of nephrotoxicity exemplified by studies of nickel nephropathy. Organ-Directed toxicity. Chemical indices and mechanisms, Eds.: S.S. Brown and D.S. Davies, Pergamon Press, Oxford, New York, Toronto, Sydney, Paris, Frankfurt, 1981; 55-67
- 16. Bruchajzer E., Szymariska J.A., Piotrowski J.K.: Acute nephrotoxicity of bromobenzene in rats: the dynamics of changes of selected biochemical parameters, Acta Polon. Toxicol., 1997; 5 (2): 183-192
Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.agro-article-e0271988-f145-4147-9b23-4bd867609ecc
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