Zaburzenia rownowagi oksydacyjno-antyoksydacyjnej u szczurow wywolane dzialaniem etanolu

• Autorzy: Lutnicki K , Szpringer E. , Marciniak A.

Warianty tytułu

EN

Ethanol evoked oxidation-antioxidation imbalance in rats

• Języki publikacji: PL

Abstrakty

EN

Ethanol administration is able to induce oxidative stress, resulting in the activation of defense mechanisms, but sometimes ROF production is very intensive and disturbs the balance between its generation and antioxidant capacity. The obtained results show that concentrations of CD, HPETE and MDA in plasma after 2hr, 12hr and 24hr pos-ethanol administration were significantly higher than in the control group of animals. 50% ethanol administered orally resulted in a significant increase of lipid peroxide levels in plasma with a simultaneous increase in SOD activity throughout the entire 24 hr period of the experiment. Gpx activity was significantly higher during the first 2 hrs following ethanol administration and then decreased to become lower than in the control group at 12 and 24 hrs. TAS in plasma decreased at hr12 and hr24 following ethanol exposure. Ethanol ingestion disturbed the plasma antioxidant system and augmented lipid peroxidation in a time dependent manner. The increased MDA production was strong evidence that lipid peroxidation is the one of main mechanisms of alcoholic tissue damage.

Słowa kluczowe

PL

szczury; rownowaga oksydacyjno-antyoksydacyjna; zaburzenia rownowagi oksydacyjno-antyoksydacyjnej; etanol; podawanie dozoladkowe; peroksydacja lipidow; lipidy; system antyoksydacyjny

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2006
• Tom: 62
• Numer: 06
• Strony: 683-685
• Opis fizyczny: s.683-685,rys.,bibliogr.

Twórcy

autor

Lutnicki K

• Akademia Medyczna, ul.Jaczewskiego 8, 20-090 Lublin

autor

Szpringer E.

autor

Marciniak A.

Bibliografia

• 1.Andrzejak R., Goch J. H., Jurga M.: Wolne rodniki i ich znaczenie w medycynie. Post. Hig. Med. Doœw. 1995, 49, 531-549.
• 2.Aydin S., Ozaras R., Uzun H., Belce A., Usulu E., Tahan V., Altug T., Dumen E., Senturk H.: N-acetylcysteine reduced the effect of ethanol on antioxidant system in rat plasma and brain tissue. Tohoku J. Exp. Med. 2002, 198, 71-77.
• 3.Bartosz G.: Druga twarz tlenu. PWN, Warszawa 1995.
• 4.Buege J. A., August S. D.: Microsomal lipid peroxidation. Meth. Enzymol. 1978, 52, 302-310.
• 5.Jordao A. A., Chiarello P. G., Arantes M. R., Mirelles M. S., Vannucchi H.: Effect of an acute dose of ethanol on lipid peroxidation in rats: action of vitamin E. Food Chem. Toxicol. 2004, 42, 459-464.
• 6.Ledwożyw A., Michalak J., Stępieñ A., Kądziołka A.: The relationship between plasma triglicerydes, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. Clin. Chim. Acta 1986, 155, 275- -284.
• 7.Liczmañski A. E.: Toksycznoœæ tlenu I, II. Post. Biochem. 1988, 34, 273-310.
• 8.Lutnicki K., Szpringer E., Czerny K., Wróbel J.: The influence of ethanol and different free radical scavengers on lipid peroxidation process and antioxidant status in the rats gastric mucosa. Annales UMCS, s. D, 1999, 54, 151- -161.
• 9.Lutnicki K., Szpringer E., Czerny K., Ledwożyw A.: Effects of ethanol and arachidonic acid pathway inhibitors on the effectiveness of gastric mucosa cytoprotection. Folia Morphol. 2001, 60, 47-56.
• 10.Mózsik Gy., Sütö G., Vincze A., Zsoldos T.: Ulcer disease. CRC Press Inc. Boca Raton Florida 2000, 15-25.
• 11.Szpringer E., Lutnicki K.: Current views on apoptosis in theory and medical practice. P. J. Vet. Sci. 2003, 6, 71-80.
• 12.Ward P. A., Till G. O., Hatherill J. R., Annesly T. M., Kunkel R. G.: Systemic complement activation, lung injury and products of lipid peroxidation. J. Clin. Invest. 1985, 76, 517-527.