Transfer of antivirals to skin Langerhans cells - A novel approach to anti-HIV treatment by Antiviral Peplotion

• Autorzy: Becker Y.
• Języki publikacji: EN

Abstrakty

EN

The analysis of the history of the research on antivirals especially the treatment of III V-l-infected individuals with antivirals which were developed prior to the current AIDS epidemic led to suggest a different approach to the targeting of antivirals in the AIDS patients. Since HIV-1 replication in infected individuals occurs in the lymph nodes, it is suggested that modified anti-Hl V-l drugs should be applied to Langerhans cells in the skin. The Langerhans cells can serve as the carries of the antiviral drugs attached to their surfaces due to their ability to migrate from the skin through the lymph vessels and to home to the lymph node. At that site Langerhans cells interact with T cells. Transfer of the anti-HIV-1 drugs to infected CD4+ T cells in the lymph node will reduce virus replication in the lymph nodes and will reduce the cytotoxic systemic effects of the antiviral drug. Such an antiviral treatment requires the development of efficient methods of drug delivery through the skin.

Słowa kluczowe

EN

antiviral drug; skin; HIV-1; keratinocyte; Langerhans cell; AIDS; lymph node; transepidermal transport; lymph vessel

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1996
• Tom: 43
• Numer: 1
• Opis fizyczny: p.175-181

Twórcy

autor

Becker Y.

• The Hebrew University of Jerusalem, Jerusalem, Israel

Bibliografia

• 1. Penman, S., Scherrer, K., Bccker, Y. & Darnell. J.F.. (1963) Polysomes in normal and poiiovirus- infected HeLa cells and their relationship to messenger RNA. Proc. Natl. Acad. Sci. U.S.A. 49, 654-662.
• 2. Rich. A.. Penman. S., Becker. Y., Darnell. J. & Hall. C. (1963) Polyribosomes: size in normal and polio-infected HeLa cells. Science 142, 1658-1663.
• 3. Becker, Y. & Joklik, W.K. (1964) Messenger RNA in cells infected with vaccinia virus. Proc. Nat!. Acad. Sci. U.S.A. 52, 577-585.
• 4. Jacob, F. & Monod. J. (1961) Genetic regulatory mechanisms in the synthesis of proteins. Mol. Biol 3,318-356.
• 5. Vol kin, E. & Sh-achan, L (1956) Intracellular distribution of labelled ribonucleic acid after phage inf<?cHon of Escherichia coli. Virology 2, 433-437.
• 6. Becker, Y. (1976) Antiviral drugs, mode of action and chemotherapy of viral infections of man; in Monographs in Virology, vol. 11, pp. 1-130, A.G. Karger, Switzerland.
• 7. Becker, Y. & Hadar, J. (1980) Antivirals 1980 — An update; in Progress in Medical Virology (Melnick. J.I... ed.) vol. 26, pp. 1 -14, A.G. Karger, Basel, Switzerland.
• 8. Prusoff, W.H. (1959) Synthesis and biological activités of iododeoxyuridine an analog of thymidine. Biochim. Biophys. Acta 32,295-296.
• 9. Hermann. E.C. (1961 ) Plaque inhibition test for detection of specific inhibitors of DNA containing viruses. Proc. Soc. Exp. Biol. Med. 107. 142-145.
• 10. Kaufman, H.E., Murola. E. & Dohlam.C. (1960) Arch. Opthalmol. 68.235-239.
• 11. Elion, B.b. (1984) Acyclovir; in Antiviral Drugs and Interferon: the molecular Ixisis of their activity. Developments in Molecular Virology (Becker, Y.. ed.) vol. 4, pp. 71-88, Martinus Neijhof Publi­shing, Boston, The Hague, Dordrecht, Lancaster.
• 12. Schaeffer, I I.J., Beauchamp, L., de Miranda, P., Elion. G.B., Bauer, D.J. & Collins, P. (1978) 9-(2-Hydroxyethoxvmethyl) guanine activity against viruses of the herpes group. Nature (London) 272. 583-585.
• 13. Becker. Y. (1984) Introduction: current trends in research on antiviral drugs; in Antiviral Drug> and Interferon: the molecular basis of their activity. Developments in Molecular Virology (Bccker, Y..eci.) vol. 4. pp. 1-9. Martinus Neijhof Publi­shing. Boston, The Hague, Dordrecht, Lancaster.
• 14. Havnes, B.F. ( 1993) Scientific and social issues of human immunodeficiency virus vaccine development. Science 260,1279-1286.
• 15. Salk, I., Bretscher, P.A., Salk. P.L., Clerici, M. & Shearer. CM. (1993) A strategy tor prophylactic vaccination against HIV. Science 260,1270-1272.
• 16. Phillips. R.K., Rowland-Jones, S., Nixon, D.F., Gotch, F.M., Edwards. J.P., Ogunlesi, A.O., Elvin. J.G., Rothbard, j.A., Bangham. CRM. & Rizza. C.R. (1991) Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Sature (London) 354,453-459.
• 17. Sabin, A.B. (1991) Effectiveness of AIDS vaccines. Science 251,1161.
• 18. Sabin, A.B. (1992) Improbability o! effective vaccination against human immunodeficiency virus because of its intracellular transmission and rectal portal of entry. Proc. Natl. Acad. Sci. U.S.A. 89,8852-8855.
• 19. Stott, F.J. (1991 ) Anti-cell antibody in Macaques. Sature (London) 353, 393.
• 20. Reid, C.D.L., Fryer, PR., Clifford, C, Kirk, A., Tikerpae, J. & Knight. S.C. <1990) Identification or hematopoietic progenitors of macrophages and dendritic Langerhans cells (DL-cFu) in human bone marrow and peripheral blood. Blood 76,1139-1149.
• 21. Knight, S.C. Stagg, A., Hill, S., Frver, P. & Griffiths, S. (1992) Development and function of dendritic cells in health and disease. /. Invest. Dermatol. 99,33S-38S.
• 22. Borgstresser, P.R., Cruz, P.D., Niederkorn, J.Y. & lakashima, A. (1992) Discussion overview. Third Internationa! Workshop on Langerhans Cells. /. Invest. Dermatol. 99, IS 4S.
• 23. Becker, Y. (19SH7) Does radiation-induced abro­gation of skin I-angerhans cell functions lead to enhanced incidence of skin tumors in patients with genetic disorders of DNA repair? Cancer Invest. 5, 505-513.
• 24. Kripke, M.L., MunnX.G., Jeevan, A., Tang,J.M. é*. Bucan, C. (1990) Evidence that cutaneous antigen-presenting cells migrate lo regional lymph nodes during contact sensitization. /. Immunol. 145, 2833-2838.
• 25. Macatonia, S.F., Knight, S.C., Edwards, A.J., Griffiths, S. à Fryer, P. (1987) Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. /. Lxp. Med. 166,1654-1667.
• 26. Larsen, C.P., Steinman, R.M., Witmer-Pack, M., Hankins, D.F., Morris, PJ. & Austvn, J.M. (1990) Migration and maturation of Langerhans cells in skin transplants and explants. /. Exp. Med. 172,1483-1493.
• 27. Banerjee, P.S. & Ritschel, YV.A. (1989) Trans­dermal permeation of vasopressin. 1. Influence of pi 1, concentration, shaving and surfactant on in vitro permeation. Int. /. Pharmaceutics 49, 189-197.
• 28. Choi, H.K., Flvnn, G.L. & Amidon. G.L. (1990) Transdermal delivery of bioactive peptides; The effect of m-decylmethyl sulfoxide, pH, and inhibitors on enkephalin metabolism and transport. Pharm. Res. 7, 1099-1106.
• 29. Becker, Y. (1994) An analysis of the role of skin Langerhans cells (LC) in the cytoplasmic processing of HIV-1 peptides after Peplotion" transepidermal transfer and HLA class I presentation to CD8* CTLs — an approach to immunization of humans. Virus Genes 9, 133-147.
• 30. Roop, D. (1995) Defects in the barrier. Science 267,474-475.