Antiapoptotic proteins as targets for bioactive compounds

• Autorzy: Pajak B.
• Języki publikacji: EN

Abstrakty

EN

One of the most promising strategies in colon cancer therapy is the sensitization of cancer cells to natural proapoptotic cytokines, such as death ligands and interferons, which are able to eliminate abnormal cells. The investigation of mechanisms determining the immune escape of cancer cells revealed the presence of antiapoptotic proteins, such as cFLIP, which inhibit cell death signal transduction. Numerous studies showed that the use of different metabolic inhibitors, such as cycloheximide (CHX), reduces the cFLIP protein level, thus restoring the susceptibility to TNF-a-induced apoptosis. However, high non-specific toxicity of CHX excludes the clinical use of this substance. The current efforts are focused on identification of bioactive compounds which could safely support immunotherapy. The review presents in vitro and in vivo evidence that butyrate (Bt), fatty acid produced in colon during fermentation process and parthenolide (PN), sesquiterpene lactone isolated from Tanacetum parthenium specifically affect different cancer cells. Among described various molecular mechanisms of Bt and PN action, one reduces the level of antiapoptotic proteins. This paper clearly demonstrates that bioactive compounds, especially combined with immune cytokines could be seriously considered as an alternative for routine colon anti-cancer therapy.

Słowa kluczowe

EN

colon cancer; butyrate; veterinary medicine; therapy; immune escape; antiapoptotic protein; bioactive compound; parthenolide

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2007
• Tom: 10
• Numer: 2
• Opis fizyczny: p.127-130,ref.

Twórcy

autor

Pajak B.

• Warsaw Agricultural University, Nowoursynowska 159, 02-776 Warsaw, Poland

Bibliografia

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