Dzialanie fitoestrogenow na organizm czlowieka i zwierzat

• Autorzy: Nowicka E , Szkudelski R. , Nogowski L.

Warianty tytułu

EN

Influence of phytoestrogens on humans and animals

• Języki publikacji: PL

Abstrakty

EN

Phytoestrogens are compounds found in plants with estrogenic activity. Their chemical structure is similar to estradiol. Three main classes of phytoestrogens are: isoflavones, lignans and coumestans. The major bioactive isoflavones are genistein and daidzein. Phytoestrogens are widely present in plants regularly consumed by animals and humans: e.g. oats, barley, wheat, corn, and clover. The most significant sources of isoflavones are soybeans and soy foods. Lignans are present in plant foods: mainly in flaxseed, but also in grains, fruit and vegetables. Phytoestrogens are compounds which exhibit estrogenic activity. This activity was first recognized in sheep and is known as “Clover Disease”. In these animals phytoestrogens cause reproductive disorders or even infertility. The feeding of female rats with a soy rich diet induces an increase in uterine weight. Vaginal modifications have also been observed. Phytoestrogens also exhibit anticarcinogenic activity. Animal studies have demonstrated reduced cancer development with soybean consumption. Genistein and other phytoestrogens have a beneficial role in obesity and diabetes mellitus. These compounds cause slight decreases in insulin, total cholesterol and triglycerides content. Phytoestrogens also increase the amount of cholesterol in high density lipoproteins (HDL) and decrease the amount of VLDL- and LDL-cholesterol, they can reduce risk of cardiovascular diseases. Experiments performed on animals demonstrate that genistein and daidzein clearly inhibit lipogenesis and enhance lipolysis. Phytoestrogens also have a special role in the prevention of osteoporosis.

Słowa kluczowe

PL

genisteina; dzialanie; dzialanie przeciwnowotworowe; oddzialywanie na organizm; dzialanie metaboliczne; fitoestrogeny; dzialanie estrogenne

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2006
• Tom: 62
• Numer: 07
• Strony: 736-738
• Opis fizyczny: s.736-738,tab.,bibliogr.

Twórcy

autor

Nowicka E

• Akademia Rolnicza, ul.Wolynska 35, 60-637 Poznan

autor

Szkudelski R.

autor

Nogowski L.

Bibliografia

• 1. Adlercreutz H.: Phytoestrogens: epidemiology and a possible role in cancer protection. Environ. Health Perspect. 1995, 103, 103-112.
• 2. Akiyama T., Ishida J., Nakagawa S., Ogawara H., Watanabe S.-I., Itoh N., Shibuya M., Fukami Y.: Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 1987, 262, 5592-5595.
• 3. Allen E., Doisy E. A.: An ovarian hormone. Preliminary report on its localization, extraction and purification, and action in test animals. JAMA 1923, 81, 819-821.
• 4. Arjmandi B. H., Alekel L., Hollis B. W.: Dietary soybean protein prevents bone loss in an ovarectomized rat model of osteoporosis. J. Nutr. 1996, 126, 161-167.
• 5. Barnes S., Peterson T. G., Coward L.: Rationale for the use of genistein-containing soy matrices in chemoprevention trials for breast and prostate cancer. J. Cell Biochem. 1995, 22, 181-187.
• 6. Bennetts H. W., Underwood E. J., Shier F. L.: A specific breeding problem of sheep on subterranean clover pastures in western Australia. Aust. Vet. J. 1946, 22, 2-12.
• 7. Beynen A. C., West C. E., Spaaij C. J., Huisman J., Van Leeuwen P., Schutte J. B., Hackeng W. H.: Cholesterol metabolism, digestion rates and postprandial changes in serum of swine fed purified diets containing either casein or soybean protein. J. Nutr. 1990, 120, 422-430.
• 8. Bhathena S. J., Velasquez M. T.: Beneficial role of dietary phytoestrogens in obesity and diabetes. Amer. J. Clin. Nutr. 2002, 76, 1191-1201.
• 9. Gallo D., Cantalemo F., Distefano M., Ferlini C., Zannini G. F., Riva A., Morazzoni P., Bombardelli E., Mancuso S., Scambia G.: Reproductive effects of dietary soy in female Wistar rats. Food Chem. Toxicol. 1999, 37, 493-502.
• 10. Hamilton R. M. G., Caroll K. K.: Plasma cholesterol levels in rabbits fed low-fat, low-cholesterol diets: Effects of dietary proteins, carbohydrates and fibre from different sources. Atherosclerosis 1976, 24, 47-62.
• 11. Haytowitz D. B., Matthews R. H.: Legumes and legume products. Washington, DC: US Department of Agriculture 1986, 1-156.
• 12. Honore E. K., Williams J. K., Anthony M. S.: Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques. Fertil. Steril. 1997, 87, 148-154.
• 13. Kalu D. N., Masoro E. J., Yu B. P., Hardin R. R., Hollic B. W.: Modulation of age-related hyperparathyroidism and senile bone loss in Fischer rats by soy protein and food restriction. Endocrinology 1988, 122, 1847-1854.
• 14. Kandulska K., Nogowski L., Szkudelski T.: Effect of some phytoestrogens on metabolism of rat adipocytes. Reprod. Nutr. Dev. 1999, 39, 497-501.
• 15. Kuiper G. G., Lemmen J. G., Carlsson B., Corton J. C., Safe S. H., van der Saag P. T., van der Burg B., Gustafsson J. A.: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998, 139, 4252-4263.
• 16. Loewe S., Lange F., Spohr E.: Über weibliche Sexualhormone (Thelytropine). Biochem. Zeitschr. 1927, 180, 1-26.
• 17. Nogowski L., Maækowiak P., Kandulska K., Szkudelski T., Nowak K. W.: Genistein-induced changes in lipid metabolism of ovariectomized rats. Ann. Nutr. Metab. 1998, 42, 360-366.
• 18. Peterson T. G., Barnes S.: Genistein inhibits both estrogen and growth factor stimulated proliferation of human breast cancer cells. Cell Growth Diff. 1996, 7, 1345-1351.
• 19. Powis G., Kozikowski A.: Growth factor and oncogene signalling pathways as targets for rational anticancer drug development. Clin. Biochem. 1991, 24, 385-397.
• 20. Price K. R., Fenwick G. R.: Naturally occurring oestrogens in foods - a review. Food Addit. Contam. 1985, 2, 73-106.
• 21. Sathyamoorthy N., Wang T. T. Y., Phang J. M.: Stimulation of pS2 expression by diet-derived compounds. Cancer Res. 1994, 54, 957-961.
• 22. Setchell K. D. R., Adlercreutz H.: Mammalian lignans and phytoestrogens. Recent studies on their formation, metabolism, and biological role in health and disease, [w:] Rowland I.: Role of the Gut Flora in Toxicity and Cancer. Academic Press, London 1988, 315-345.
• 23. Setchell K. D. R., Gosselin S. J., Welsh M. B., Johnston J. O., Balistreri W. F.: Dietary estrogens - a probable cause of infertility and liver disease in captive cheetahs. Gastroenterology 1987, 93, 225-233.
• 24. Shutt D. A., Cox R. I.: Steroid and phytoestrogen binding to sheep uterine receptors in vitro. Endocrinology 1972, 52, 299-310.
• 25. Smith R. M., Tiesinga J. J., Shah N., Smith J. A., Jarett L.: Genistein inhibits insulin-stimulated glucose transport and decreases immunocytochemical labeling of GLUT4 carboxyl-terminus without affecting translocation of GLUT4 in isolated rat adipocytes: additional evidence of GLUT4 activation by insulin. Arch. Biochem. Biophys. 1993, 300, 238-246.
• 26. Szkudelska K., Nogowski L., Kaczmarek P., Pruszyńska-Oszmałek E., Szkudelski R., Sieczka A., Szkudelski T.: Hormonal and metabolic effects of genistein and daidzein in male rat. J. Anim. Feed Sci. 2003, 12, 841-849.
• 27. Szkudelska K., Szkudelski T., Nogowski L.: Daidzein, coumestrol and zearalenone affect lipogenesis and lipolysis in rat adipocytes. Phytomedicine 2002, 9, 338-345.
• 28. Szkudelski T., Nogowski L., Pruszyńska-Oszmałek E., Kaczmarek P., Szkudelska K.: Genistein restricts leptin secretion from rat adipocytes. J. Steroid. Biochem. Mol. Biol. 2005, 96 (praca w druku).
• 29. Thiagarajan D. G., Bennink M. R., Bourguin L. D., Kavas F. A.: Prevention of precancerous colonic lesions in rats by soy flakes, soy flour, genistein, and calcium. Amer. J. Clin. Nutr. 1998, 68, 1394-1399.
• 30. Thompson L. U., Robb P., Serraino M., Cheung F.: Mammalian lignan production from various foods. Nutr. Cancer 1991, 16, 43-52.
• 31. Yanagihara K., Ito A., Toge T., Numoto M.: Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract. Cancer Res. 1993, 53, 5815-5821.
• 32. Young V. R.: Soy protein in relation to human protein and amino acid nutrition. J. Am. Diet. Assoc. 1991, 91, 828-835.
• 33. Zava D. T., Duwe G.: Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro. Nutr. Cancer 1997, 27, 31-40.