Czasopismo
Tytuł artykułu
Warianty tytułu
Języki publikacji
Abstrakty
Istnieje szereg badań, których wyniki świadczą o tym, iż w okresie okołomenopauzal- nym dieta zawierająca związki fitoestrogenne może wpływać na zmniejszenie częstości incydentów sercowo-naczyniowych, wywoływać korzystne zmiany metaboliczne w tkance kostnej, nie wywierając jednocześnie proliferacyjnego wpływu na gruczoł sutkowy oraz endometrium. W świetle najnowszych doniesień o wynikach badań nad klasyczną hormonalną terapią zastępczą (Women's Health Initiative 2002, One Million Women Study 2003) wiele kobiet może wybrać naturalne metody łagodzenia dolegliwości okresu klimakterycznego. Fitoestrogeny, czyli substancje pochodzenia roślinnego o działaniu estrogennym, mogą stanowić jedną z form wyżej wymienionych terapii. Praca stanowi przegląd aktualnego piśmiennictwa związanego z badaniami i zastosowaniem fitoesto- genów jako potencjalnej alternatywy dla hormonalnej terapii zastępczej.
The findings of many epidemiological and clinical studies indicate that consumption of a diet rich in phytoestrogens can exert the cardioprotective, anti-osteoporotic and other beneficial effects of the estrogens used in hormone replacement therapy in postmenopausal women without adversely affecting the risk of thrombosis and the incidence of breast and uterine cancers. The recent results from The Women's Health Initiative and One Million Women Study, which assess the use of hormone replacement therapy (HRT), demonstrate an increased risk of cardiovascular disease and breast cancer among postmenopausal women. As a result, there is an increasing interest in the use of alternative therapies for menopause symptoms. One of these alternatives are phytoestrogens. Phytoestrogens represent a family of plant compounds that have been shown to have both estrogenic and antiestrogenic properties. This article reviews the evidence for the potential of phytoestrogens, either in dietary or supplemental form, to replace traditional forms of HRT.
Słowa kluczowe
Wydawca
Czasopismo
Rocznik
Tom
Numer
Strony
417-426
Opis fizyczny
s.417-426,rys.,bibliogr.
Twórcy
autor
- Akademia Medyczna, ul.Polna 33, 60-533 Poznan
autor
autor
Bibliografia
- 1. REES M., PURIDE D.: Non-hormone replacement therapy options and alternative therapies. Management of the menopause. In: The handbook of British Menopause Society, 2nd Ed. Mar- low: BMS Publications Ltd 1999, 42.
- 2. NEWTON K.M., BUIST D.S.M., KEENAN N.L.: Use of alternative therapies for menopause symptoms: results of a population-based survey. Obstet. Gynecol. 2002, 100,18.
- 3. LO EWE S., LANGE F., SPHOR E.: Uber weilie Sexual hormone (Thelytropine). Biochem. Zeitschr. 1926, 180, 1.
- 4. GRYNKIEWICZ G., GADZIKOWSKA M.: Fitoestrogeny jako selektywne modulatory aktywności receptorów estrogennych. Post. Fitoter. 2003, 10, 28.
- 5. DIXON R.A., FERREIRA D.: Genistein. Phytochem. 2002, 60, 205.
- 6. XU X., HARRIS K.S., WANG H.J. i wsp.: Bioavailability of soybean isoflavones depends upon gut microflora in women. J. Nutr. 1995, 125, 2307.
- 7. PIKE A.C.W., BRZOZOWSKI A.M., HUBBARD R.E.: A structural biologist's view of the oestrogen receptor. J. Steroid. Biochem. Biol. 2000, 74, 261.
- 8. BORRELLI F., IZZO A.A., ERNST E.: Pharmacological effects of Cimicifuga racemosa. Life Sei. 2003, 73, 1215.
- 9. WUTTKE W„ SEIDLOVÁ-WUTTKE D., GORKOW C.: The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas 2003, 44, 67.
- 10. KNIGHT D.C., EDEN J.A.: Phytoestrogens a short review. Maturitas 1995, 22, 167.
- 11. ALBERTAZZI P., PURDIE D.: The nature and utility of the phytoestrogens: a review of the evidence. Maturitas 2002, 42, 173.
- 12. HAN K.K., SOARÉS J.R., JOSE M. i wsp.: Benefits of soy isoflavone therapeutic regimen on menopausal symptoms. Obstet. Gynecol. 2002, 99, 389.
- 13. MUÑOZ H., PLUCHINO G.: Salvatore Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancer. Maturitas 2003, 44, 59.
- 14. HORN-ROSS P.L., JOHN E.M., CANCHOLA A.J.: Phytoestrogen intake and endometrial cancer risk. J. Natl. Cancer. Inst. 2003, 95, 1158.
- 15. JOHNSON E.B., MUTO M.G., YANUSHPOLSKY E.H.: Phytoestrogen supplementation and endometrial cancer. Obstet. Gynecol. 2001, 98, 947.
- 16. WILCOX G., WAHLQVIST M.L., BURGER H.G.: Oestrogenic effects of plant foods in postmenopausal women. BMJ 1990, 301, 905.
- 17. CHIECH1 L.M., PUT1GNANO G„ GUERRA V.: The effect of a soy rich diet on the vaginal epithelium in postmenopause: a randomized double blind trial. Maturitas 2003, 45, 241.
- 18. CLARKSON T.B., ANTHONY M.S., MORGAN T.M.: Inhibition of postmenopausal atherosclerosis progression: a comparison of the effects of conjugated equine estrogens and soy phytoestrogens. J. Clin. Endocrinol. Metab. 2001, 86, 41.
- 19. SQUADRITO F., ALTAVILLA D„ CRISAFULLI A.: Effect of genistein on endothelial function in postmenopausal women: a randomized, double-blind, controlled study. Am.J. Med. 2003, 114, 470.
- 20. NAKASH1MA S., KOIKE T., NOZAWA Y.: Genistein, a protein tyrosine kinase inhibitor, inhibits thromboxane A2-mediated human platelet responses. Molec. Pharmacol. 1991, 39, 475.
- 21. TEEDE H., DALAI S F., KOTSOPOULOS D.: Dietary phytoestrogens improve lipid profiles and blood pressure: A double-blind randomized placebo-controlled study in men and postmeno- pauzal women. Circulation 1999, 100, 1.
- 22. NESTEL P.J., POMEROY S., KAY S.: Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J. Clin. Endocrinol. Metab. 1999, 84, 895. Erratum in: J. Clin. Endocrinol. Metab. 1999, 84, 3647.
- 23. HODGSON J.M., PUDDEY I.B., BEILIN L.J.: Effects of isoflavonoids on blood pressure in subjects with high-normal ambulatory blood pressure levels: A randomized controlled trial. Am. J. Hy- pertens. 1999, 12, 47.
- 24. AYMAN A.A.: Ewes phytoestrogens in the management of the menopause up-to-date. Obstet. Gynecol. Survey. 2002, 5, 306.
- 25. ANDERSON J.W., JOHNSTONE B.M., COOK-NEWELL M.E.: Meta-analysis of the effects of soy protein intake on serum lipids. N. Engl. J. Med. 1995, 333, 276.
- 26. FITZPATRICK, LORRAINE A.: Soy isoflavones: hope or hype? Maturitas 2003, 44, 21.
- 27. LAUDERDALE D.S., JACOBSEN S.J., FURNER S.E.: Hip fracture incidence among elderly Asian-American populations. Am. J. Epidemiol. 1997, 146, 502.
- 28. CHIN K., EVANS M.C., CORNISHJ.: Differences in hip axis and femoral neck length in premenopausal women of Polynesian, Asian and European origin. Osteo. Int. 1997, 7, 344.
- 29. CHOI E.M., SUH K.S., KIM Y.S.: Soybean ethanol extract increases the function of osteoblastic MC3T3-E1 cells. Phytochem. 2001, 56, 733.
- 30. POTTER S.M., BAUM J.A., TENG H.: Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am. J. Clin. Nutr. 1998, 68, 1375.
- 31. ALEKEL D.L., GERMAIN A.S., PETERSON C.T.: Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am. J. Clin. Nutr. 2000, 72, 844.
- 32. CLIFTON-BL1GH P.B., BABER R.J., FULCHER G.R. i wsp.: The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism. Menopause 2001, 8, 259.
- 33. CHIECHI L.M., SECRETO G., DAMORE M.: Efficacy of a soy rich diet in preventing postmenopausal osteoporosis: the Menfis randomized trial. Maturitas 2002, 42, 295.
- 34. MISHRA S.I., DICKERSON V., NAJM W.: Phytoestrogens and breast cancer prevention: What is the evidence? Am. J. Obstet. Gynecol. 2003, 188, 66.
- 35. CHEN W.F., HUANG M.H., TZANG C.H.: Inhibitory actions of genistein in human breast cancer (MCF-7) cells. Bioch. Biopli. Acta 2003, 1638, 187.
- 36. INGRAM D.M., HICKLING.C, WEST L.: A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. Breast 2002, 11, 170.
- 37. TOMASZEWSKI J.: Fitoestrogeny. W: Klimakterium, hormonalna terapia zastępcza (J.A. Jako- wicki). Poradnik Terapeutyczny. Biofolium, Lublin 2001.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-article-c1b43bed-37ee-49b2-bd48-7ab784a86838