Sesbania grandiflora diminishes oxidative stress and ameliorates antioxidant capacity in liver and kidney of rats exposed to cigarette smoke

• Autorzy: Ramesh T. , Sureka C. , Bhuvana S. , Hazeena Begum V.
• Języki publikacji: EN

Abstrakty

EN

Cigarette smoke is a major risk factor for many chronic diseases. However, it may be possible to relieve the smoke-induced damage by increasing the defensive system. In this study, we planned to evaluate the protective mechanism of Sesbania grandiflora (S. grandiflora) leaves against cigarette smoke-induced oxidative damage in liver and kidney of rats. Adult male Wistar-Kyoto rats were exposed to cigarette smoke for a period of 90 days and consecutively treated with S. grandiflora aqueous suspension (SGAS, 1000 mg/kg body weight per day by oral gavage) for a period of 3 weeks. Hepatic marker enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), as well as renal markers such as urea and creatinine were analysed in serum. Lipid peroxidation marker mainly thiobarbituric acid reactive substances (TBARS) and antioxidant enzymes namely superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) and glucose-6-phosphate dehydrogenase (G6PDH) activities and non-enzymatic antioxidants such as reduced glutathione, ascorbic acid and a-tocopherol levels were studied. In addition, micronutrients mainly copper (Cu), zinc (Zn), manganese (Mn) and selenium (Se) levels were analyzed in liver and kidney of rats exposed to cigarette smoke. The results indicated that SGAS significantly decreased the elevated hepatic, renal and lipid peroxidation markers and ameliorated the diminished antioxidant levels while restored the hepatic and renal architecture in cigarette smoke-exposed rats. This study concludes that S. grandiflora leaves restrain cigarette smoke-induced oxidative damage in liver and kidney of rats.

Słowa kluczowe

EN

Sesbania grandiflora; oxidative stress; cigarette smoke; risk factor; chronic disease; hepatic marker enzyme; aspartate aminotransferase; alanine aminotransferase; alkaline phosphatase; lipid peroxidation; thiobarbituric acid; superoxide dismutase; catalase; glutathione reductase; glutathione-S-transferase; oxidative damage; antioxidant; liver; kidney; micronutrient

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2010
• Tom: 61
• Numer: 4
• Strony: 467-476
• Opis fizyczny: p.467-476,fig.,ref.

Twórcy

autor

Ramesh T.

• Konkuk University, 322 Danwol-Dong, Chungju, Chungbuk, 380-701, Korea

autor

Sureka C.

autor

Bhuvana S.

autor

Hazeena Begum V.

Bibliografia

• Church DF, Pryor WA. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985; 64: 111-126.
• Yoshie Y, Ohshima H. Synergistic induction of DNA strand breakage by cigarette tar and nitric oxide. Carcinogenesis 1997; 18: 1359-1363.
• Weis LM, Rummel AM, Masten SJ, Trosko JE, Upham BL. Bay or baylike regions of polycyclic aromatic hydrocarbons were potent inhibitors of Gap junctional intercellular communication. Environ Health Perspect 1998; 106: 17-22.
• Izzotti A, Bagnasco M, Cartiglia C, et al. Chemoprevention of genome, transcriptome, and proteome alterations induced by cigarette smoke in rat lung. Eur J Cancer 2005; 41: 1864-1874.
• Gad HI, Hassan IE. Study of the effect of cigarette smoking exposure, medroxyprogesterone acetate injection on oxidative damage in female rats. Alex Med J 1999; 41: 345-368.
• Rodrigo R, Rivera G. Renal damage mediated by oxidative stress: a hypothesis of protective effects of red wine. Free Radic Biol Med 2002; 33: 409-422.
• Halliwell B. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 1994; 344: 721-724.
• Zondervan KT, Ocke MC, Smit HA, Seidell J. Do dietary and supplementary intakes of antioxidants differ with smoking status? Int J Epidemiol 1996; 25: 70-79.
• Rekha PS, Kuttan G, Kuttan R. Antioxidant activity of brahma rasayana. Ind J Exp Biol 2001; 39: 447-452.
• Dilsiz N, Olcucu A, Cay M, Naziroglu M, Cabanoglu D. Protective effects of selenium, vitamin C and vitamin E against oxidative stress of cigarette smoke in rats. Cell Biochem Funct 1999; 17: 1-7.
• Anbarasi K, Vani G, Balakrishna K, Shyamala Devi CS. Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats. Life Sci 2006; 78: 1378-1384.
• Hsu CL, Wu YL, Tang GJ, Lee TS, Kou YR. Ginkgo biloba extract confers protection from cigarette smoke extract-induced apoptosis in human lung endothelial cells: role of heme oxygenase-1. Pulm Pharmacol Ther 2009; 22: 286-296.
• Florek E, Ignatowicz E, Piekoszewski W. Effect of pregnancy and tobacco smoke on the antioxidant activity of rutin in an animal model. Pharmacol Rep 2009; 61: 935-940.
• The ATBC Study Group. Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. JAMA 2004; 290: 476-485.
• Duffield-Lillico AJ, Begg CB. Reflections on the landmark studies of beta-carotene supplementation. J Natl Cancer Inst 2004; 96: 1729-1731.
• The Wealth of India. Raw materials, Vol. 9. Council of Scientific Industrial Research (CSIR); New Delhi, India, 1972, pp. 295-298.
• Ching LS, Mohamed S. Alpha-tocopherol content in 62 edible tropical plants. J Agric Food Chem 2001; 49: 3101-3105.
• Kasture VS, Deshmukh VK, Chopde CT. Anxiolytic and anticonvulsive activity of Sesbania grandiflora leaves in experimental animals. Phytother Res 2002; 16: 455-460.
• Das P, Raghuramulu N, Rao KC. Determination of in vitro availability of iron from common foods. J Hum Ecol 2005; 18: 13-20.
• Joshi SG, Leguminoceae. Textbook of Medicinal Plants, Oxford and TBH Publishing Co Pvt Ltd; New Delhi, India, 2000. 130.
• Pari L, Uma A. Protective effect of Sesbania grandiflora against erythromycin estolate-induced hepatotoxicity. Therapie 2003; 58: 439-443.
• Shrivastav N, Janin SK. Plants bearing antifertility properties. Hamdard Med 1993; 36: 91-98.
• Tamboli SA. Anti-inflammatory activity of Sesbania grandiflora. Ind Drug 1996; 33: 504-506.
• Tamboli SA. Analgesic and antipyretic activity of Sesbania grandiflora. Ind Drug 2000; 37: 95-98.
• Doddola S, Pasupulati H, Koganti B, Prasad KV. Evaluation of Sesbania grandiflora for antiurolithiatic and antioxidant properties. J Nat Med 2008; 62: 300-307.
• Ramesh T, Hazeena Begum V. Protective effect of Sesbania grandiflora against cigarette smoke induced oxidative damage in rats. J Med Food 2008; 11: 369-375.
• Ramesh T, Mahesh R, Sureka C, Hazeena Begum V. Cardioprotective effects of Sesbania grandiflora in cigarette smoke-exposed rats. J Cardiovasc Pharmacol 2008; 52: 338-343.
• Eun-Mi P, Young-Mee P, Young-Seob G. Oxidative damage in tissues of rats exposed to cigarette smoke. Free Radic Biol Med 1998; 25: 79-86.
• Beuge JA, Aust SD. The thiobarbituric acid assay. Method Enzymol 1978; 52: 306-307.
• Kakkar B, Das PN, Viswanathan A. Modified spectrophotometric assay of SOD. Ind J Biochem Biophys 1984; 21: 130-132.
• Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972; 47: 389-394.
• Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973; 179: 588-590.
• Staal GE, Visser J, Veeger C. Purification and properties of glutathione reductase of human erythrocytes. Biochim Biophys Acta 1969; 185: 39-48.
• Habig WH, Pabst MJ, Jakpoby WB. Glutathione transferase: a first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249: 7130-7139.
• Ellis HA, Kirkman HN. A colorimetric method for assay of erythrocyte glucose-6-phosphatase dehydrogenase. Proc Soc Exp Biol Med 1961; 106: 607-609.
• Moron MS, de Pierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione-S-transferase in rat lung and liver. Biochim Biophys Acta 1979; 82: 67-70.
• Omaye ST, Turnbull JD, Sauberlich HE. Selected methods for the determinations of ascorbic acid in animal cell, tissues and fluids. Method Enzymol 1979; 67: 1-11.
• Baker H, Frank O, De Angelis B, Feingold S. Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol. Nutr Rep Int 1980; 21: 531-536.
• Lowry OH, Roseborough NJ, Farr AL, Randall RJ. Protein measurement with folin-phenol reagent. J Biol Chem 1951; 193: 265-275.
• Lerner L, Weiner D, Katz R, Reznick AZ, Pollack S. Increased pro-inflammatory activity and impairment of human monocyte differentiation induced by in vitro exposure to cigarette smoke. J Physiol Pharmacol 2009; 60(Suppl 5): 81-86.
• Vanisree AJ, Sudha N. Curcumin combats against cigarette smoke and ethanol-induced lipid alterations in rat lung and liver. Mol Cell Biochem 2006; 288: 115-123.
• Vijayakumar G, Srinivasan SR, Dhanapalan P. Preliminary study on the effect of indigenous plant Sesbania grandiflora in carbon tetrachloride induced hepatitis in calves. Ind J Vet Med 1997; 17: 17-21.
• Cigremis Y, Turkoz Y, Akgoz M, Sozmen M. The effects of chronic exposure to ethanol and cigarette smoke on the level of reduced glutathione and malondialdehyde in rat kidney. Urol Res 2004; 32: 213-218.
• Hoffmeyer F, Harth V, Bunger J, Bruning T, Raulf-Heimsoth M. Leukotriene B4, 8-iso-prostaglandin F2 alpha, and pH in exhaled breath condensate from asymptomatic smokers. J Physiol Pharmacol 2009; 60(Suppl 5): 57-60.
• Ramesh T, Mahesh R, Hazeena Begum V. Effect of Sesbania grandiflora on lung antioxidant defense system in cigarette smoke exposed rats. Int J Biol Chem 2007; 1: 141-148.
• Singh RP, Banerjee S, Kumar PVS, Raveesha KA, Rao AR. Tinospora cordifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice. Phytomedicine 2006; 13: 74-84.
• Choi SW, Benzie IF, Collins AR, Hannigan BM, Strain JJ. Vitamins C and E, acute interactive effects on biomarkers of antioxidant defence and oxidative stress. Mutat Res 2004; 551: 109-117.
• Lapenna D, de Gioia S, Mezzetti A, et al. Cigarette smoke, ferritin, and lipid peroxidation. Am J Res Crit Car Med 1995; 151: 431-435.
• Smith CJ, Livingston SD, Doolittle DJ. An international literature survey of IARC Group I carcinogens. Reported in mainstream cigarette smoke. Food Chem Toxicol 1997; 35: 1107-1130.
• Satarug S, Ujjin P, Vanavanitkun Y, Nishijo M, Baker JR, Moore MR. Effects of cigarette smoking and exposure to cadmium and lead on phenotypic variability of hepatic CYP2A6 and renal function biomarkers in men. Toxicology 2004; 204: 161-173.
• Sulochana KN, Ramakrishnan S, Punitham R, Biju J. Cadmium and superoxide dismutase in tobacco chewers with cataract. Ind J Pharmacol 1998; 30: 413.
• Groten JP, Sinkeldam EJ, Muys T, Luten JB, Van Bladeren PJ. Interaction of dietary Ca, P, Mg, Mn, Cu, Fe, Zn and Se with the accumulation and oral toxicity of cadmium in rats. Food Chem Toxicol 1991; 29: 249-258.
• Ramadori G, Moriconi F, Malik I, Dudas J. Physiology and pathophysiology of liver inflammation, damage and repair. J Physiol Pharmacol 2008; 59(Suppl 1): 107-117.
• Garcia-Frenandez AJ, Bayoumi AE, Perez-Pertejo Y, et al. Alterations of the glutathione-redox balance induced by metals in CHO-K1 cells. Comp Biochem Phys 2002; 132C: 365-373.
• Markovich D, James KM. Heavy metals mercury, cadmium and chromium inhibit the activity of the mammalian liver and kidney sulfate transporter Sat-1. Toxicol Appl Pharmacol 1999; 154: 181-187.
• Khandelwal S, Shukla LJ, Shanker R. Modulation of acute cadmium toxicity by Emblica officinalis fruit in rat. Ind J Exp Biol 2002; 40: 564-570.