The antimutagenic activity of two plant - derived compounds. A comparative cytogenetic study

• Autorzy: Gasiorowski K. , Brokos B. , Kozubek A. , Oszmianski J.
• Języki publikacji: EN

Abstrakty

EN

The antimutagenic activity of alkylresorcinols from cereal grains and anthocyanins from Aronia melanocarpa fruit were compared in three short-term mphocyte tests: a sister chromatid exchange test, a cytokinesis-blocked micronucleus assay and a thioguanine-resistance test. It was noticed that both tested compounds significantly decreased the rate and frequency of mutations induced in cultured lymphocytes with two standard mtagens: benzo[a]pyrene and mitomycin C. Alkylresorcinols appeared to be acre potent antimutagenic compounds than anthocyanins. Anthocyanins exhibited a stronger inhibitory effect on the generation and release of free radicals by human granulocytes in vitro, as measured with the NBT-reduction test. The results suggest that alkylresorcinols and anthocyanins exerted an antimutagenic influence through multifarious mechanisms, one of which could be a limitation of free radical involvement in mutagenesis.

Słowa kluczowe

EN

blood cell; antimutagenesis; alkylresorcinol; Aronia melanocarpa; fruit; short-term lymphocyte test; antimutagenic activity; anthocyanin; cereal grain; short-term test; lymphocyte; lymphocyte proliferation; sister chromatid exchange test

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2000
• Tom: 05
• Numer: 2
• Opis fizyczny: p.171-190,fig.

Twórcy

autor

Gasiorowski K.

• Wroclaw Medical University, 14 Kochanowskiego Str., 51-601 Wroclaw, Poland

autor

Brokos B.

autor

Kozubek A.

autor

Oszmianski J.

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