Preparation and properties of alkylphospholipid liposomes: A review

Zeisig, R; Fichtner, I.; Arndt, D.

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Artykuł - szczegóły

Czasopismo

Cellular and Molecular Biology Letters

1996 | 01 | 4 |

Tytuł artykułu

Preparation and properties of alkylphospholipid liposomes: A review

Autorzy

Zeisig R. , Fichtner I. , Arndt D.

Warianty tytułu

Języki publikacji

Abstrakty

Alkylphospholipids are synthetic compounds with relatively simple structures combining amphiphilic character and anticancer properties. It is possible to prepare different types of liposomes from APL if a high amount of cholesterol and a charged component is added. The biological relevant properties can be changed by sterical stabilization of these vesicles by the incorporation of up to 10 mol% poly(ethylenglycol) derivatives of phosphoethanolamine. This incorporation increased the fixed aqueous layer thickness from 0.83 nm to 3.57 nm. As a result of this changed property the uptake of such liposomes by macrophages was reduced compared to liposomes without a sterical stabilization. APL liposomes are remarkably stable in buffer and in plasma. APL-liposomes are able to induce the release of tumoricidal factors like TNF and NO from different macrophage cell lines. The strongest release was induced by a synergistic action of liposomal APC and lipopolysaccharide. Sterical stabilization prevents such an activation process likely as a result of significantly reduced uptake and internalization by the macrophages. APL are highly therapeutically active in a number of hormone-independent human mammary carcinomas. Using the MaTu mammary carcinoma xenotransplanted to nude mice the sterically stabilized HPC-SUV have the strongest cancerostatic formulation.

Słowa kluczowe

mammary carcinoma human serum phagocytosis alkylphosphocholine in vivo alkylphospholipid cytotoxicity liposome man anticancer activity macrophage activation synthetic compound therapeutic effect

Wydawca

Czasopismo

Cellular and Molecular Biology Letters

Rocznik

1996

Tom

Numer

Opis fizyczny

p.447-457

Twórcy

autor

Zeisig R.

Max Delbruck Center for Molecular Medicine, R.-Rossle- Str.10, 13122 Berlin-Buch, Germany

autor

Fichtner I.

autor

Arndt D.

Bibliografia

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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-b9a49443-248e-43fe-9df0-dcdbc3cbd283