Effect of gamma irradiation on intestinal crypts survival in mice pretreated with N-nitrosodiethylamine

• Autorzy: Grudzinski I P
• Języki publikacji: EN

Abstrakty

EN

A new mathematical equation was developed by which whole-body exposure to gamma radiation may be used to predict the survival characteristic of the intestinal crypt in mice pretreated with N-nitrosodiethylamine (NDEA). A computer fitting procedure showed the best agreement between predicted and observed curves. The results suggest that less cells may survive in crypts after gamma irradiation of NDEA-treated mice.

Słowa kluczowe

EN

intestinal crypt; mouse; proliferation; mice; N-nitrosodiethylamine; gamma-irradiation; gamma-radiation; survival

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2000
• Tom: 09
• Numer: 4
• Opis fizyczny: p.281-283,fig.

Twórcy

autor

Grudzinski I P

• Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland

Bibliografia

• 1. POTTEN C.S. A comprehensive study of the radiobiological response of the murine (BCF1) small intestine. Int. J. Radi­at. Biol. 6, 925, 1990.
• 2. POTTEN C.S., LOEFFLER M. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110, 1001, 1990.
• 3. PAULUS U., POTTEN C.S, LOEFFLER M. A model of the control of cellular regeneration in the intestinal crypt after perturbation based solely on local stem cell regulation. Cell Prolif. 25, 559, 1992.
• 4. GRUDZINSKI I.P., LAW F.C.P. Induction of cell death in the intestinal crypt of mice following oral administration of nitrate and nitrite. Bull. Environ. Contam. Toxicol. 60, 185, 1998.
• 5. GRUDZINSKI I.P. Analiza komórek klonogennych w kryp­tach jelita cienkiego gamma napromieniowanych myszy w zatruciu azotanem potasowym i azotynem sodowym. Lek. Wojsk, 74, 669, 1998.
• 6. GRUDZINSKI I.P. Zatrucie azotynem sodowym - matryca przeżywalności krypt. Lek. Wojsk, 74, 538, 1998.
• 7. LI Y.Q., FAN C.Y., O'CONNOR D.J, WINTON D.J., POTTEN C.S. Target cells for the cytotoxic effects of car cinogens in the murine small intestine. Carcinogenesis 13, 361, 1992.
• 8. POTTEN C.S, HENDRY J.H, MOORE J.V, CHWALINSKI S. Cytotoxic effects in gastro-intestinal epi thelium (as exemplified by small intestine). In Cytotoxic In suit to Tissue: Effects on cell lineage (C.S. Potten, and J.H. Hendry, Eds.), pp. 105-153. Churchill-Livingstone, Edin burgh, 1983..
• 9. WITHERS H.R, ELKIND M.M. Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. Int. J. Radiat. Biol. 17, 261, 1970.
• 10. POTTEN C.S, REZVANI M, HENDRY J.H, MOORE J.V, MAJOR D. The correction of intestinal microcolony counts for variation in size. Int. J. Radiat. Biol. 3, 321, 1981.
• 11. MOORE J.V. Death of intestinal crypts and of their constituent cells after treatment by chemotherapeutic drugs. Br. J. Cancer 49, 25, 1984.
• 12. WITHERS H.R, MASON K.A., TAYLOR J.M.G. The number of clonogenic cells in a mouse jejunal crypt. Radiotherapy Oncol. 26, 238, 1993.
• 13. GILBERT C.W. Computer programs for fitting puck and probit survival curves. Int. J. Radiat. Biol. 16, 323, 1969.
• 14. ROBERTS S.A. Drfit: A program for fitting radiation survival models. Int. J. Radiat. Biol. 57, 1243, 1990.
• 15. HENDRY J.H, POTTEN C.S. Cryptogenic cells and prolif erative cells in intestinal epithelium. Int. J. Radiat. Biol. 6, 583, 1974.
• 16. HORNSEY S. The microcolony assay in small intestine. In: Cell clones, Eds. CS. Potten and JH. Hendry. Churchill-Livingstone. Edinburg. p. 44-49, 1985 .
• 17. PETO R, GRAY G, BRANTON P, GRASSO P. Dose and time relationships for tomor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of yV-nit- rosodiethylamine or TV-nitrosodimethylamine. Cancer Res. 51, 6452, 1991
• 18. COHEN SM. Cell proliferation and carcinogenesis. Drug Metab. Reviews 30, 339, 1998.