Combined delivery of an antiangiogenic protein [angiostatin] and an immunomodulatory gene [interleukin-12] in the treatment of murine cancer

• Autorzy: Wilczynska U. , Kucharska A. , Szary J. , Szala S.
• Języki publikacji: EN

Abstrakty

EN

We investigated the feasibility of a novel therapeutic approach to treat neoplastic diseases in mice. This novel strategy consists in delivering a protein (angiostatin) with strong antiangiogenic properties, followed by administration of the interleukin 12 gene that is strongly immunomodulatory and has also some antiangiogenic effects. When angiostatin-mediated antiangiogenic therapy was used in combination with intratumor delivery of the IL-12 gene (a strategy much safer than IL-12 protein admin­istration), this produced a synergistic therapeutic effect.

Słowa kluczowe

EN

gene therapy; angiostatin; treatment; murine cancer; angiogenesis; interleukin 12; tumour; cancer; immunomodulatory gene

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 4
• Opis fizyczny: p.1077-1084,fig.

Twórcy

autor

Wilczynska U.

• Center of Oncology Maria Sklodowska-Curie Memorial Institute, Wybrzeze Armii Krajowej 15, 44-101 Gliwice, Poland

autor

Kucharska A.

autor

Szary J.

autor

Szala S.

Bibliografia

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