Anti-inflammatory effects of extracts from some traditional Mediterranean diet plants

• Autorzy: Strzelecka M. , Bzowska M. , Koziel J. , Szuba B. , Dubiel O. , Rivera Nunez D. , Heinrich M. , Bereta J.
• Języki publikacji: EN

Abstrakty

EN

It is believed that bioactive compounds from plant foods may have health beneficial effects and reduce the risk of chronic inflammatory diseases. In this study extracts of 121 plants typical for the traditional Mediterranean diet have been screened for their potential anti-inflammatory activities. The ability of the extracts to inhibit cytokinestimulated, iNOS-dependent synthesis of nitric oxide in murine endothelial cells, without affecting cell viability, was the primary indicator of their anti-inflammatory properties. Based on these experiments we selected eight plant extracts for further analysis: Chrysanthemum coronarium L., Scandix pecten-veneris L., Urospermum picroides (L.) Scop. Ex F. W. Smith, Amaranthus cf. graecizans L., Onopordum macracanthum Schousboe, Eryngium campestre L., Artemisia alba Turra and Merendera pyrenaica (Pourret) Fourn. Only the effects of Onopordum macracanthum could be non-specific since the extract strongly inhibited total protein synthesis. All remaining 7 extracts decreased nitric oxide and TNFa synthesis in the cells of monocyte origin activated with LPS, and 4 of them significantly reduced surface expression of VCAM1 on TNFa-stimulated endothelial cells. All seven plant extracts decreased cytokine or LPS-stimulated iNOS mRNA levels in both cell types. Further research to identify bioactive compounds influencing intracellular signaling pathways activated by cytokines and LPS will consequently be needed in order to better understand these in vitro effects.

Słowa kluczowe

EN

Mediterranean diet; bioactive compound; antiinflammatory activity; nitric oxide; tumour necrosis factor-alpha; plant food; chronic inflammatory disease

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology. Supplement
• Rocznik: 2005
• Tom: 56
• Numer: 1
• Strony: 139-156
• Opis fizyczny: p.139-156,fig.,ref.

Twórcy

autor

Strzelecka M.

• Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

autor

Bzowska M.

autor

Koziel J.

autor

Szuba B.

autor

Dubiel O.

autor

Rivera Nunez D.

autor

Heinrich M.

autor

Bereta J.