Autofagia w przebudowie gruczolu mlekowego bydla

• Autorzy: Gajewska M , Gajkowska B. , Sobolewska A. , Motyl T.

Warianty tytułu

EN

Autophagy in the remodeling of bovine mammary glands

• Języki publikacji: PL

Abstrakty

EN

Autophagy is a process responsible for the degradation and recycling of cytoplasmic content by lysosomes. It is thought to facilitate cell survival during periods of nutrient starvation, but it can also be involved in other physiological processes including regulation of protein homeostasis, degrading intracellular bacteria, tumor suppression and regulation of programmed cell death. Our group was the first to report autophagy in bovine mammary epithelial cells, both in vitro, on BME-UV1 mammary epithelial cell line, and in vivo. The highest intensity of autophagy in bovine mammary glands is noted during dry periods, when the gland undergoes intensive involution and the deprivation of bioactive compounds (hormones, growth factors, cytokines) and nutrients occur. Our studies on the regulation of autophagy show that the conditions observed during bovine mammary gland involution, such as: 1) decrease in the release of lactogenic hormones and growth factors (prolactin, GH and IGF-I); 2) increase of apoptogenic factors (i.e. TGF-β₁) and their receptors, 3) increased synthesis of sex steroids (17-β estradiol, progesterone); and 4) the enhanced competition of intensively developing fetus and mother organism for nutritional and bioactive compounds, may create a state of temporary malnutrition of mammary epithelial cells that forces the cells to the induction of autophagy as a mechanism stabilizing intracellular supplies of energy and aminoacids, especially during the enhanced activity of apoptogenic factors.

Słowa kluczowe

PL

gruczoly mlekowe; bydlo; autofagia; regulacja

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 11 Supl.
• Strony: 1412-1416
• Opis fizyczny: s.1412-1416,rys.,fot.,bibliogr.

Twórcy

autor

Gajewska M

• Szkola Glowna Gospodarstwa Wiejskiego, ul.Nowoursynowska 159, 02-766 Warszawa

autor

Gajkowska B.

autor

Sobolewska A.

autor

Motyl T.

Bibliografia

• 1.Bauvy C., Gane P., Arico S., Codogno P., Ogier-Denis E.: Autophagy delays sulindac sulfide-induced apoptosis in human intestinal colon kancer cell line HT-29. Exp. Cell. Res. 2001, 268, 139-149.
• 2.Boya P., Gonzalez-Polo R. A., Poncet D., Andreau K., Vieira H. L., Roumier T., Perfettini J. L., Kroemer G.: Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine. Oncogene 2003, 22, 3927-3936.
• 3.Capuco A. V., Akers R. M.: Mammary involution in diary animals. J. Mammary Gland Neoplasia. 1999, 4, 137-144.
• 4.Cuervo A. M.: Autophagy: in sickness and in health. Trends Cell Biol. 2004, 14, 70-77.
• 5.Gajewska M., Gajkowska B., Motyl T.: Apoptosis and autophagy induced by TGF-β1 in bovine mammary epithelial BME-UV1 cells. J. Physiol. Pharmacol. 2005, 56, 143-157.
• 6.Hammond E. M., Brunet C. L., Johnson G. D., Parkhill J., Milner A. E., Brady G., Gregory C. D., Grand R. J. A.: Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast. FEBS Lett. 1998, 425, 391-395.
• 7.Inbal B., Bialik S., Sabanay I., Shani G., Kimchi A.: DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. J. Cell Biol. 2002, 157, 455-468.
• 8.Kihara A., Kabeya Y., Ohsumi Y., Yoshimori T.: Beclin-phosphatidylinositol 3 - kinase complex functions at the trans-Golgi network. EMBO Rep. 2001, 2, 330-335.
• 9.Lamparska-Przybysz M., Gajkowska B., Motyl T.: Cathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer MCF-7 cells exposed to camptothecin. J. Physiol. Pharmacol. 2005, 56, 159-179.
• 10.Lemasters J. J., Qian T., He L., Kim J. S., Elmore S. P., Cascio W. E., Brenner D. A.: Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis and autophagy. Antioxid. Redox. Signal. 2002, 4, 769-781.
• 11.Levine B., Klionsky D. J.: Development by self-digestion: molecular mechanisms and biological functions of autophagy. Develop. Cell 2004, 6, 463-477.
• 12.Liang X. H., Kleeman L. K., Jiang H. H., Gordon G., Goldman J. E., Berry G., Herman B., Levine B.: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 1998, 72, 8586-8596.
• 13.Meijer A., Codogno P.: Regulation and role of autophagy in mammalian cells. Int. J. Biochem. Cell Biol. 2004, 36, 2445-2462.
• 14.Mills K. R., Reginato M., Debnath J., Queenan B., Brugge J. S.: Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc. Natl. Acad. Sci. 2004, 101, 3438-3443.
• 15.Mizushima N.: Methods for monitoring autophagy. Int. J. Biochem. Cell Biol. 2004, 36, 2491-2502.
• 16.Moore M. N., Allen J. I., Somerfield P. J.: Autophagy: role in surviving environmental stress. Mar. Environ. Res. 2006, 62, 420-425.
• 17.Motyl T., Gajkowska B., Zarzyńska J., Gajewska M., Lamparska-Przybysz M.: Apoptosis and autophagy in mammary Gland remodeling and breast cancer chemotherapy. J. Physiol. Pharm. 2006a, 57, 17-32.
• 18.Motyl T., Zarzyńska J., Gajewska M., Gajkowska B.: Regulacja programowanej śmierci komórki w przebudowie gruczołu mlekowego bydła. Folia Univ. Agric. Stetin., Zootech. 2006b, 250, 57-66.
• 19.Ohsumi Y.: Molecular dissection of autophagy: two ubiquitin-like systems. Nat. Rev. Mol. Cell. Biol. 2001, 2, 211-216.
• 20.Sekulic A., Hudson C. C., Homme J. L., Yin P., Otterness D. M., Karnitz L. M., Abraham R. T.: A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 2000, 60, 3504-3513.
• 21.Shimizu S., Kanaseki T., Mizushima N., Mizuta T., Arakawa-Kobayashi S., Thompson C. B., Tsujimoto Y.: Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat. Cell Biol. 2004, 6, 1221-1228.
• 22.Smith G. H., Chepko G.: Mammary epithelial stem cells. Micr. Res. Technique 2001, 52, 190-203.
• 23.Vivanco I., Sawyers C. L.: The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2002, 2, 489-501.
• 24.Vogt P. K.: PI 3-kinase, mTOR, protein synthesis and cancer. Trends Mol. Med. 2001, 7, 482-484.
• 25.Waręski P., Motyl T., Ryniewicz Z., Orzechowski A., Gajkowska B., Wojewódzka U., Płoszaj T.: Expression of apoptosis-related proteins in mammary gland of goat. Small Rum. Res. 2001, 40, 279-289.
• 26.Wilde C. J., Knight C. H., Flint D. J.: Control of milk secretion and apoptosis during mammary involution. J. Mammary Gland Biol. Neoplasia 1999, 4, 129-136.
• 27.Zarzyńska J., Motyl T.: Molekularny mechanizm inwolucji gruczołu mlekowego krowy. Medycyna Wet. 2005, 61, 1110-1113.
• 28.Zarzyńska J., Gajewska M., Motyl T.: Effects of hormones and growth factors on TGF-β1 expression in bovine mammary epithelial cells. J. Diary Res. 2005, 72, 39-48.
• 29.Zarzyńska J., Gajkowska B., Wojewódzka U., Dymnicki E., Motyl T.: Apoptosis and autophagy in involuting bovine mammary gland is accompanied by up-regulation of TGF-β1 and suppression of somatotropic pathway. Polish J. Vet. Sci. 2007, 10, 1-9.