Oxidative DNA base modifications as factors in carcinogenesis

• Autorzy: Olinski R. , Jaruga P. , Zastawny T.H.
• Języki publikacji: EN

Abstrakty

EN

Reactive oxygen species can cause extensive DNA modifications including modified bases. Some of the DNA base damage has been found to possess premutagenic properties. Therefore, if not repaired, it can contribute to carcinogenesis. We have found elevated amounts of modified bases in cancerous and precancerous tissues as compared with normal tissues. Most of the agents used in anticancer therapy are paradoxically responsible for induction of secondary malignancies and some of them may generate free radicals. The results of our experiments provide evidence that exposure of cancer patients to therapeutic doses of ionizing radiation and anticancer drugs causes base modifications in genomic DNA of lymphocytes. Some of these base damages could lead to mutagenesis in critical genes and ultimately to secondary cancers such as leukemias. This may point to an important role of oxidative base damage in cancer initiation. Alternatively, the increased level of the modified base products may contribute to genetic instability and metastatic potential of tumor cells.

Słowa kluczowe

EN

ionizing radiation; anticancer drug; patient; tumour cell; lymphocyte; carcinogenesis; DNA base damage; reactive oxygen species; anticancer therapy; free radical; oxidative DNA

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1998
• Tom: 45
• Numer: 2
• Opis fizyczny: p.561-572,fig.

Twórcy

autor

Olinski R.

• The Ludwik Rydygier Medical University in Bydgoszcz, M.Karlowicza 24, 84-092 Bydgoszcz, Poland

autor

Jaruga P.

autor

Zastawny T.H.

Bibliografia

• 1. HaUiweU, B. & Gutteridge, M.C. (1989) Free Radicals in Biology and Medicine, 2nd edn., Clarendon Press, Oxford.
• 2. Chance, B., Sies, H. & Boveris, A. (1979) Hy­droperoxide metabolism in mammalian or­gans. Physicl. Rev. 59, 527-605.
• 3. Ohshima, H. & Bartsch, H. (1994) Chronic in­fections and inflammatory processes as can­cer risk factors: Possible role of nitric oxide in carcinogenesis. Mutat. Res. 305, 253-264.
• 4. Martinez-Cayuela, M. (1995) Oxygen free radi­cals and human disease. Biochimie 77, 147- 161.
• 5. Kolachana, P., Subrahmanyam, V.V., Meyer, K.B., Zhang, L. & Smith, M.T. (1993) Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo. Cancer Res. 53, 1023- 1026.
• 6. Shen, H.M., Ong, C.N., Lee, B.L. & Shi, C.Y. (1995) Ailatoxin Bl-induced 8-hydroxydeoxy- guanosine formation in rat hepatic DNA. Car­cinogenesis 16, 419-422.
• 7. Mauthe, R.J., Cook, V.M., Coffing, S.L. & Baird, W.M. (1995) Exposure of mammalian cell cultures to benzo[a]pyrene and light re­sults in oxidative DNA damage as measured by 8-hydroxydeoxyguanosine formation. Car­cinogenesis 16, 133-137.
• 8. Sussman, M.S. & Bulkley, G.B. (1990) Oxygen- derived free radicals in reperfusion injury. Methods EnzymoL 186, 711-723.
• 9. Zimmerman. B.J. & Granger, D.N. (1992) Reperfusion injury. Surg. Clin. North Am. 72, 711-723.
• 10. Ames, B.N. & Gold. L. (1991) Endogenous mu­tagens and the causes of aging and cancer. Mu­tation Res. 250, 3-16.
• 11. Halliwell, B. (1993) Oxidative DNA damage: Meaning and measurement; in DNA and Free Radicals (Halliwell, B. & Aruoma. O.I., eds.) pp. 67-75, Ellis Horwood, London.
• 12. Von Sonntag, C. (1987) The chemical basis of radiation biology, Taylor & Francis, London.
• 13. Dizdaroglu, M. (1993) Chemistry of free radi­cal damage to DNA and nucleoproteins; in DNA and Free Radicals (Halliwell, B. & Aruoma, O.I., eds.) pp. 19-34, Ellis Horwood, London.
• 14. Feig, D.I., Reid, T.M. & Loeb, L.A. (1994) Re­active oxygen species in tumorigenesis. Can­cer Res. 54, 1890-1894.
• 15. Floyd, R.A. (1990) The role of 8-hydroxy- guanine in carcinogenesis. Carcinogenesis 11, 1447-1450.
• 16. Dizdaroglu, M. (1992) Oxidative damage to DNA in mammalian chromatin. Mutation Res. 275, 331-342.
• 17. Dizdaroglu, M. (1993) Quantitative determina­tion of oxidative base damage in DNA by sta­ble isotope-dilution mass spectrometry. FEBS Lett 315, 1-6.
• 18. Cheng, K.C., Cahill, D.S., Kasai, H., Nishi- mura, S. & Loeb. L.A. (1992) 8-Hydroxy- guanine, an abundant form of oxidative DNA damage, causes G-*T and A-*C substitutions. J. Biol. Chem. 267, 166-172.
• 19. Hussain, S.P., Aguilar, F., Amstad, P. & Ce- rutti, P. (1994) Oxy-radical induced mutagene­sis of hotspot codons 248 and 249 of the hu­man p53 gene. Oncogene 9, 2277-2281.
• 20. Le Page. F., Marot, A., Grollman, A.P., Sara- sin, A. & Gentil, A. (1995) Mutagenicity of a unique 8-oxoguanine in a human Ha-ras se­quence in mammalian cells. Carcinogenesis 16, 2779-2784.
• 21. Oiinski, R., Zastawny, T., Budzbon, J., Sko- kowski, J., Zegarski, W. & Dizdaroglu, M. (1992) DNA base modifications in chromatin of human cancerous tissues. FEBS Lett 309, 193-198.
• 22. Jaruga, P., Zastawny, T.H., Skokowski, J., Dizdaroglu, M. & Oiinski, R. (1994) Oxidative DNA base damage and antioxidant enzyme ac­tivities in human lung cancer. FEBS Lett. 341, 59-64.
• 23. Kamiya, H., Ueda, T., Ohgi, T., Matsukage. A. & Kasai, H. (1995) Misincorporation of dAMP opposite 2-hydroxyadenine, an oxidative form of adenine. Nucleic Acids Res. 23, 761-766.
• 24. Kamiya, H. & Kasai, II. (1995) Formation of 2- hydroxydeoxyadenosine triphosphate, an oxi- datively damaged nucleotide, and its incorpo­ration by DNA polymerases. Steady-state ki­netics of the incorporation. J. Biol Chem. 270, 19446-19450.
• 25. Kamiya, H., Miura, H., Murata-Kamiya, N., Ishikawa, H., Sakagushi, T., Inoue, H., Sasaki, T., Masutani,C., Hanaoka, F., Nishimura, S. & Ohtsuka, E. (1995) 8-Hydroxy-adenine (7,8- dihydro-8-oxoadenine) induces misincorpora­tion in in vitro DNA synthesis and mutations in N1H 3T3 cells. Nucleic Acids Res. 23, 2893- 2899.
• 26. Purmal, A.A., Kow, Y.K. & Wallace, S.S. (1994) Major oxidative products of cytosine, 5- hydroxycytosine and 5-hydroxyuracil, exhibit sequence cor.textrdependent mispairing in vi­tro. Nucleic Acids Res. 22, 72-78.
• 27. Feig, D.I., Sowers, L.C., Loeb. L.A. (1994) Re­verse chemical mutagenesis: Identification of the mutagenic lesions resulting from reactive oxygen species-mcdiated damage to DNA. Froc. Natl Acad. Sci. U.S.A. 91,6609- 6613.
• 28.0no, T., Negishi, K. & Hayatsu, H. (1995) Spectra of superoxide-induced mutations in the lacl gene of a wild-type and a mutM strain of Escherichia coli K-12. Mutation Res. 326. 175-183.
• 29. Oiinski, R., Zastawny, T.H., Foksinski, M., Barecki, A. & Dizdaroglu. M. (1995) DNA base modifications and antioxidant enzyme activi­ties in human benign prostatic hyperplasia. Free Radical Biol Med. 18. 807-813.
• 30. Collins, A., Cadet. J., Epe, B. & Gedik, C. (1997) Problems in the measurement of 8- oxoguanine in human DNA. Report of a work­shop, DNA Oxidation; Aberdeen, U.K., 19-21 January, 1997, Carcinogenesis, 18, 1833- 1836.
• 31. Malins, D.C. & Haimanot, R. (1991) Major al­terations in the nucleotide structure of DNA in cancer of the female breast. Cancer Res. 51, 5430-5432.
• 32. Pryor, W.A. & Prier, D.G. (1983) Church-DF electron-spin resonance study of mainstream and sidestream cigarette smoke: Nature of the free radicals in gas-phase smoke and in ciga­rette tar. Environ. Health PerspecL 47, 345- 355.
• 33. Eccles, S.A. & Alexander, P. (1974) Sequestra­tion of macrophages in growing tumours and its effect on the immunological capacity of the host Br. J. Cancer 30, 42-49.
• 34. Dizdaroglu, M., Oiinski, R., Doroshow, J.H. & Akman, S.A. (1993) Modification of DNA bases in chromatin of intact target human cells by activated human polymorphonuclear leukocytes. Cancer Res. 53, 1269-1272.
• 35.Szatrowski. T.P. & Nathan. C.F. (1991) Pro­duction of large amounts of hydrogen perox­ide by human tumor cells. Cancer Res. 51, 794-798.
• 36. Sun, Y. (1990) Free radicals, antioxidant en­zymes, and carcinogenesis. Free Radical Biol Med. 8. 583-599.
• 37. Kasprzak, K.S., Jaruga, P., Zastawny, T.H., North, S.L., Riggs, C., Oliriski, R. & Dizdaro- glu, M. (1997) Oxidative DNA base damage and repair in kidneys and livers of nickel (Il> treated male F344 rats. Carcinogenesis 18, 271-277.
• 38. Malms, D.C., Polissar, N.L. & Gunselman, S.J. (1996) Progression of human breast cancers to the metastatic state is linked to hydroxyl radical-induced DNA damage. Proc. Natl Acad. Sci. U.S.A. 93, 2557-2563.
• 39. Partin, A.W., Getzenberg, R.H., CarMichael, M.J.. Vindivich. D., Yoo, J.. Epstein, J.I. & Cof­fey, D.S. (1993) Nuclear matrix protein pat­terns in human benign prostatic hyperplasia and prostate cancer. Cancer Res. 53, 744- 746.
• 40. Castro, J.R. & Curtis, S.B. (1992) The applica­tion of particle beams to radiation therapy; in Radiation Biology (Pizzarello, D.J. & Colom- betti, L.D., eds.) pp. 265-285, CRC Press, Boca Raton.
• 41. Olinski, R., Zastawny, T.H., Foksinski, M., Windorbska, W., Jaruga, P. & Dizdaroglu, M. (1996) DNA base damage in lymphocytes of cancer patients undergoing radiation therapy. Cancer Lett. 106, 207-215.
• 42. Akman, S.A., Doroshow, J.H., Burke, T.G. & Dizdaroglu, M. (1992) DNA base modifica­tions induced in isolated human chromatin by NADH dehydrogenase-catalyzed reduction of doxorubicin. Biochemistry 31, 3500-3506.
• 43.Olinski, R., Jaruga, P., Foksinski, M., Bi­ałkowski, K. & Tujakowski, J. (1997) Epirubi- cin induced oxidative DNA damage and evi­dence for its repair in lymphocytes of cancer patients who are undergoing chemotherapy. Molec. Pharm. 52, 882-885.
• 44.Setlow, R.B. (1993) Variations in DNA repair among humans; in Human Carcinogenesis, pp. 141-168, Academic Press, New York.
• 45.Inskip, P.D., Kleinerman, R.A., Stovall, M., Cookfair, D.L., Hadjimichael, 0., Moloney, W.C., Monson, R.R., Thompson, W.D. & Waclawski-Wende, J. (1993) Leukemia, lym­phoma, and multiple myeloma after pelvic ra­diotherapy for benign disease. Radiat. Res. 135, 108-124.
• 46. Anderson, R.D. & Berger, N.A. (1994) Muta­genicity and carcinogenicity of topoisomerase- interactive agents. Mutation Res. 309, 109- 142.
• 47. Lajtha, L.G. (1981) Which are the leukemic cells? Blood Cells 7, 45-62.
• 48. Clayson, D.B., Mehta, R. & Iverson, F. (1994) International Commission for Protection Against Environmental Mutagens and Car­cinogens. Oxidative DNA damage — The ef­fects of certain genotoxic and operationally non-genotoxic carcinogens. Mutation Res. 317, 25-42.