Association between alpha-adducin gene polymorphism [Gly460Trp] and genetic predisposition to salt sensitivity: a meta-analysis

• Autorzy: Wang R , Zhong B , Liu Y , Wang C
• Języki publikacji: EN

Abstrakty

EN

Linkage and association studies suggested the relationship between α-adducin polymorphism (Gly460Trp; rs4961) and genetic susceptibility to salt-sensitivity. However, the currently available results were inconsistent. This study aimed to define quantitatively the association between salt-sensitivity and α-adducin Gly460Trp polymorphism in all published case-control studies. Publications from PubMed and other databases were retrieved. The major inclusion criteria were: (1) case-control design; (2) salt-sensitivity confirmed by sodium loading tests, and (3) the distribution of genotypes given in detail. Seven case-control studies fulfilled the inclusion criteria. In total they involved 820 subjects (454 salt-sensitive and 366 non-salt-sensitive). The meta-analysis shows that Gly460Trp polymorphism in general is not significantly associated with salt-sensitivity [OR (95%CI): 1.40 (0.96,2.04), P = 0.08]. Subgroup analysis showed that the association is statistically significant in Asian people [OR (95%CI): 1.33 (1.06, 1.69), P = 0.02] but not in Caucasian people [OR (95%CI): 1.98 (0.57, 6.92), P = 0.28]. This indicates that blood pressure response to sodium varies between ethnical groups. More studies based on a larger population are required to evaluate further the role of α-adducin Gly460Trp polymorphism in salt-sensitive hypertension.

Słowa kluczowe

PL

alpha-adducin; salt-sensitive hypertension; blood pressure; genetic factor; environmental factor; risk factor; gene polymorphism; genetic predisposition; salt sensitivity

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 2010
• Tom: 51
• Numer: 1
• Strony: 87-94
• Opis fizyczny: p.87-94,fig.,ref.

Twórcy

autor

Wang R

• Department of Cardiology, Affiliated Hospital of Youjiang, Youjiang Medical College for Nationalities, Baise, Guangxi, China

autor

Zhong B

• Affiliated Mental Health Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

autor

Liu Y

• Tianjin University of TCM, Tianjin, China

autor

Wang C

• Baylor College of Medicine and The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Bibliografia

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