Negative chronotropic effect of endothelin-1 [ET-1] in the cardiac pacemaker tissue

• Autorzy: Goraca A.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to asses the direct effect of ET-1 on spontaneous discharge rate of the pacemaker tissue in the presence of isoproterenol. The experiments were performed on pacemaker tissue of the isolated right auricle of the right heart atrium of a two-day-old rat. The spontaneous discharge rate of the pacemaker tissue was recorded on the ECG apparatus and analyzed by the computer. ET-1 alone did not significantly affect the discharge rate of the pacemaker tissue. Isoproterenol rapidly increased the discharge rate of the pacemaker tissue. ET-1 had negative chronotropic effect in the presence of isoproterenol. JKC – 301, a blocker of ETA receptors, significantly reduced the negative chronotropic effect of ET-1 in the presence of isoproterenol, whereas IRL – 1038, a blocker of ETB receptors, did not significantly affect the negative chronotropic effect of ET-1 in the presence of isoproterenol. In conlusion, the negative chronotropic effect of ET-1 in the presence of beta-adrenergic stimulation the pacemaker tissue of the right auricle of the right heart atrium of the two-day-old rat is mediated by ETA receptors.

Słowa kluczowe

EN

negative chronotropic effect; peptide; endothelin-1; pacemaker tissue

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2003
• Tom: 54
• Numer: 1
• Opis fizyczny: p.53-63,fig.

Twórcy

autor

Goraca A.

• Medical University of Lodz, Mazowiecka 6-8 street, 92-215 Lodz, Poland