Badania elektrofizjologiczne serca u swin w eksperymentalnej hipertyroksynemii

• Autorzy: Noszczyk-Nowak A

Warianty tytułu

EN

Electrophisiological study of the heart in swine during experimental hyperthyroxinemia

• Języki publikacji: PL

Abstrakty

EN

The aim of this research was to evaluate the assessment of changes of heart electrophisiological parameters, the determination of the frequency of occurrence and kinds of arrhythmias possible to release in invasive electrophysiological study of the heart and the assessment of the connection between electrophysiological parameters and morphological changes of the heart muscle. The experimental material included 10 pigs of Wielka Bia³a Zwis³oucha breed. Hyperthyroxinemia was induced experimentally in 5 pigs through the oral administration of L-tyroxine at a dose of 20 µg/kg body weight once daily for 8 weeks. The control group included 5 pigs which were not administered L-tyroxine. The electrophysiological study of the heart was carried out 4 times, preceded by a blood test. The statistically significant shortening of the atrial effective refraction period and atrio-ventriculat nodal refraction period, concentric hypertrophy of the heart muscle, and change of biochemical blood parameters were observed.

Słowa kluczowe

PL

serce; hipertyroksynemia; swinia; miesien sercowy; trzoda chlewna; zmiany morfologiczne; badania elektrofizjologiczne; arytmie

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 10
• Strony: 1242-1246
• Opis fizyczny: s.1242-1246,fot.,tab.,bibliogr.

Twórcy

autor

Noszczyk-Nowak A

• Uniwersytet Przyrodniczy we Wroclawiu, pl.Grunwaldzki 47, 50-366 Wroclaw

Bibliografia

• 1.Allessie M., Boyden P., Camm A., Kleber A., Lab M., Legato M., Rosen M., Schwartz P., Spooner P., van Wagoner D., Waldo A.: Pathophysiology and prevention of atrial fibrillation. Circulation 2001, 103, 769-777.
• 2.Auer J., Scheibner P., Mische T., Langsteger W., Eber O., Eber B. Ł.: Subclinical hyperthyroidism as risk factor for atrial fibrillation. Am. Heart J. 2001, 142, 838-842.
• 3.Bahouth S. W.: Thyroid hormones transcriptionally regulator the β-1 adrenergic receptor gene in cultured ventricular myocyte. J. Biol. Chem. 1991, 266, 15863-15869.
• 4.Basset A., Blanc J., Hegege A., Elghozi J.: Renin-angiotensin system contribution to cardiac hypertrophy in experimental hyperthyroidism: an echocardiographic study. J. Cardiovasc. Pharmacol. 2001, 37, 163-172.
• 5.Biondi B., Fazio S., Coltroti F., Palmieri E., Carella C., Lombardi G., Sacca L.: Reentrant atrioventricular nodal tachycardia induced by levotyhyroxine. J. Clin. Endocrin. Metab. 1998, 83, 2643-2645.
• 6.Biondi B., Palmieri E., Lombardi G., Fazio S.: Effects of thyroid hormone on cardiac function: the relative importance of heart rate, loading conditions, and myocardial contractility in regulation cardiac performance in human hyperthyroidism. J. Clin. Endocrin. Metab. 2002, 87, 968-974.
• 7.Braunwald E., Zipes D., Libby P.: Heart Disease. Saunders W. B. Co. New York 2001, 659-774, 815-889, 2151-2171.
• 8.Cernohorsky J., Pelouch V., Korecky B., Vetter R.: Thyroid control of sarcolemmal Na⁺/Ca⁺ exchanger and SR Ca²⁺ - ATPase in developing rat heart. Am. J. Physiol. 1998, 275, 264-273.
• 9.Colzani R. M., Emdin M., Conforti F., Passino C., Scarlattini M., Iervasi G.: Hyperthyroidism is associated with lengthening of ventricular repolarization. Clin. Endocrinol. 2001, 55, 27-32.
• 10.Dąbrowska B., Dąbrowski A.: Podręcznik elektrokardiografii. PZWL Warszawa 2002, 18-23.
• 11.Dorr M., Wolff B., Robinson D., John U., Ludemann J., Meng W., Felix S., Volzke H.: The association of thyroid function with cardiac mass and left ventricular hypertophy. J. Clin. Endocrinol. Metab. 2005, 90, 673-677.
• 12.Dudley S. C., Baumgarten C. M.: Bursting of cardic sodium channels after acute exposure to 3,5,3'-triiodo-L-thyronine. Circ. Res. 1993, 73, 301-313.
• 13.Fenelon G., Wijns W., Andries E.: Tachycardiomyopathy: mechanisms and clinical implications. Pacing. Clin. Elactrophysiol. 1996, 19, 95-106.
• 14.Franklyn J. A., Gammage M. D.: Thyroid hormones and the heart: biology and clinical implications of hyperthyroidism and its treatment. Curr. Opin. Endocrinol. Diabetes. 2000, 7, 275-300.
• 15.Gajek J., Zięba I., Zyśko D.: Studies on the relationship between beta-adrenergic receptor density on cell wall lymphocytes, total serum catecholamine level and heart rate in patients with hyperthyroidism. Pol. Merkuriusz Lek. 2000, 9, 541-543.
• 16.Goldman L., Sahlas D., Sami M.: A case of thyrotoxicosis and reversible systolic cardiac dysfunction. Can. J. Cardiol. 1999, 15, 811-814.
• 17.Hammond H., White F., Buxton I., Saltzstein P., Brunton L., Longhurst J.: Increased myocardial β-receptors and adrenergic responses in hyperthyroid pigs. Am. J. Physiol. 1987, 252, H283-H290.
• 18.Hocini M., Ho S., Kawara T., Linnenbank A., Potse M., Shah D., Jais P., Janse M., Haissaguerre M., Bakker J.: Electrical conduction in canine pulmonary veins. Circulation 2002, 105, 2442-2448.
• 19.Kahaly G. J., Dillmann W. H.: Thyroid hormone action in the heart. Endocrine Rev. 2005, 4, 1-47.
• 20.Komiya N., Isomoto S., Nakao K., Hayano M., Yano K.: Electrophysiological abnormalities of the atrial muscle in patients with paroxysmal atrial fibrillation associated with hyperthyroidism. Clin. Endocrinol. 2002, 56, 39-44.
• 21.Kuncova J., Slavikova J.: Vasoactive intestinal polypeptide in rat atria: the effect of hyperthyroidism. Physiol. Res. 2000, 49, 427-434.
• 22.Mason J. W.: Electrophysiologic study versus electrocardiographic monitoring investigators: A comparison of electrophysiologic testing with Holter monitoring to predict antiarrhythmic - drug efficacy for ventricular tachyarrhythmias. N. Engl. J. Med. 1993, 329, 445-451.
• 23.Morovat A., Dauncey M. J.: Regulation of porcine skeletal muscle nuclear 3,5,3'-tri-iodothyronine receptor binding capacity by thyroid hormones: modification by energy balance. J. Endocrinology 1995, 144, 233-242.
• 24.Moustaghfir A., Kharchafi A., Belmejdoub G., Chaari J., Ghafir D., Hda A., Ohayon V., Archane M.: Cardiothyrotoxicosis in young adult in Basedow disease: report of 30 cases. Ann. Cardiol. Angiol. 2000, 49, 161-167.
• 25.Olshausen K., Bischoff S., Kahaly G.: Cardiac arrhythmias and heart rate in hyperthyroidism. Am. J. Cardiol. 1989, 63, 930-935.
• 26.Presti C. F., Hart R. G.: Thyrotoxicosis, atrial fibrillation, and embolism, revisited. Am. Heart J. 1989, 117, 996-997.
• 27.Raddino R., Scarabelli T., Ferrari R., Potera C., Sarasso L., Foppani A., Pizzocardo C.: Right ventricular heart failure in hyperthyroidism. Minerva Cardioangiol. 2001, 49, 335-341.
• 28.Ślebodziński A.: Endokrynologia zwierząt domowych. PWN, Warszawa 1970, s. 80-97.
• 29.Świątecka G., Bieganowska K., Kargul W., Kornacewicz-Jach Z., Kutarski A., Lewicka-Nowak E., Lubiński A., Musiał A., Piwowarska W., Prochaczek F., Sadowski Z., Truszcz-Gluza M., Walczak F., Wojciechowski D.: Wskazania do badania elektrofizjologicznego. Folia Cardiologica 1999, 1, supl. 1, 46-51.
• 30.Willems R., Holemans P., Ector H., Sipido K., van de Werf F., Heidbuchel H.: Mind the model: effect of instrumentation on inducibility of atrial fibrillation in sheep model. J. Cardiovasc. Electrophysiol. 2002, 13, 62-67.
• 31.Winnicka A.: Wartości referencyjne podstawowych badañ laboratoryjnych w weterynarii. SGGW Warszawa 1997, 17-67.
• 32.Vos M., de Groot S., Verduyn S., van der Zande J., Leunissen H., Cleutjens J., van Bilsen M., Daemen M., Schreuder J., Allessie M., Wellens H.: Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block in related to cardiac hypertrophy and electrical remodeling. Circulation 1998, 98, 1125-1135.
• 33.Zipes D. P., DiMarco J. P., Gillette P. C., Jackman W. M., Myerburg R. J., Rahimtoola S. H., Ritchie J. L., Cheitlin M. D., Garson A., Gibbons R. J., Lewis R. P., O'Rourke R. A., Ryan T. J., Schlant R. C.: Guidelines for clinical intracardiac electrophysiological and catheter ablation procedures. J. Am. Coll. Cardiol. 1995, 26, 555-573.
• 34.Yu Y., Bilezikian J.: Tachycardia-induced cardiomiopathy secundary to thyrotoxicosis: a young man with previously unrecognized Graves' disease. Thyroid 2000, 10, 923-927.