Phenol red in the culture medium strongly affects the susceptibility of human MCF-7 cells to roscovitine

• Autorzy: Wesierska-Gadek J , Schreiner T. , Maurer M. , Waringer A. , Ranftler C.
• Języki publikacji: EN

Abstrakty

EN

Estrogens play an important role in the growth and terminal differentiation of the mammary gland. Prolonged exposure to estrogens seems to predispose women to breast cancer. It recently became evident that not only the intrinsic hormonal status but also external factors such as the occurrence of pharmaceuticals and chemicals with hormone activity in the environment may put women at greater risk of developing breast cancer. We focused on the interference of endocrine disruptors in breast cancer therapy. We observed that phenol red added to the culture medium strongly promoted the cell proliferation and cell cycle progression of human cells expressing the estrogen receptor, and affected their susceptibility to chemotherapy.

Słowa kluczowe

EN

phenol red; estrogen receptor; cancer therapy; woman; cell proliferation; chemotherapy; estrogen; endocrine disrupting compound; human cell; cancer risk; mammary gland; roscovitine; breast cancer; cell cycle progression

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2007
• Tom: 12
• Numer: 2
• Opis fizyczny: p.280-293,fig.,ref.

Twórcy

autor

Wesierska-Gadek J

• Vienna Medical University, Borschkegasse 8a, A-1090 Vienna, Austria

autor

Schreiner T.

autor

Maurer M.

autor

Waringer A.

autor

Ranftler C.

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