Czasopismo
Tytuł artykułu
Warianty tytułu
Influence of unidirectional pulsed electrical current stimulation on femur fracture healing in rabbits
Języki publikacji
Abstrakty
The failure of the therapy of fractures in the form of a delayed union of the fractured bone or lack of this union, gave rise to research on the best conditions that are essential for a successful regeneration of the bone. The aim of this study was to present a semi-invasive stimulation method in vivo. The femur in 20 rabbits was sawed, and then stabilized by the Mikro-Zespol method. Electrostimulation was not used in the control group. Pulsed unidirectional electrical current of 70 micro A, 25% filled and 1 Hz (mean value 17.5 micro A) was applied in the experimental group to stimulate the fracture area. The animals were clinically and radiologically assessed. Bones of the sacrificed animals were sampled for histological examination. The bone repair process was more advanced in the experimental group in comparison to the control group in early research periods. Any pathologic findings related to cytotoxicity and carcinogenesis were not observed in livers and kidneys of the animals. This is an animal study and further clinical trials are needed to determine whether semi-invasive electrical stimulation method will be able to reduce the rate of bone healing disturbances.
Wydawca
Czasopismo
Rocznik
Tom
Numer
Strony
1622-1626
Opis fizyczny
s.1622-1626,fot.,tab.,bibliogr.
Twórcy
autor
- Slaska Akademia Medyczna, pl.Medyków 1, 41-200 Sosnowiec
autor
autor
autor
autor
Bibliografia
- 1.Basset C. A.: The development and application of pulsed electromagnetic fields for ununited fractures and arthrodeses. Clin. Plast. Surg. 1985, 12, 259-277.
- 2.Bielecki T., Gazdzik T. S., Szczepanski T.: Re: The effects of local platelet rich plasma delivery on diabetic fracture healing. What do we use: Platelet-rich plasma or platelet-rich gel? Bone 2006, 39, 1388.
- 3.Brighton C. T., Wang W., Seldes R., Zhang G., Pollack S.: Signal transduction in electrically stimulated bone cells. J. Bone Joint Surg. 2001, 83A, 1514-1523.
- 4.Chen Y. J., Wurtz C. J., Wang C. J., Kuo Y. R., Yang K. D., Huang H. C., Wang F. S.: Recruitment of mesenchymal stem cells and expression of TGF beta1 and VEGF in early stage of shock wave promoted bone regeneration of segmental defect in rats. J. Orthop. Res. 2004, 22, 526-534.
- 5.Chi-Chuan W., Wen-Jer C.: A revised protocol for more clearly classifying a nonunion. J. Orthop. Surg. 2000, 8, 45-52.
- 6.Deszczyñski J., Szczęsny G.: Proces zrostu kości patofizjologia i zagadnienia kliniczne. Przebieg zrostu kostnego oraz czynniki fizyczne warunkuj¹ce jego wystąpienie. Ortop. Traum. Rehab. 2000, 4, 24-29.
- 7.Duncan R., Turner C.: Mechanotransduction and the functional response of bone to mechanical strain. Calcif. Tissue Int. 1995, 57, 344-358.
- 8.Dwayer N., Matthews B.: The electrical response to stress in died, recently excised and living bone. Injury 1970, 4, 279-284.
- 9.El-Hakim I. E., Azim A. M., El-Hassan M. F., Maree S. M.: Preliminary investigation into the effects of electrical stimulation on mandibular distraction osteogenesis in goats. Int. J. Oral Maxillofac. Surg. 2004, 33, 42-47.
- 10.Friedenberg Z. B., Harlow M. C., Happenstall R. B., Brighton C. T.: The cellular origin of bioelectric potentials in bone. Calcif. Tissue Res. 1972, 13, 53-59.
- 11.Gaździk T. S.: Zakażenia w ortopedii. Urban&Partner, Wrocław 2005, 4-166.
- 12.Hamanishi C., Kawabata T., Yoshii T., Tanaka S.: Bone mineral density changes in distracted callus stimulated by pulsed direct electrical current. Clin. Orthop. Relat. Res. 1995, 312, 247-252.
- 13.Hannouche D., Petite H., Sedel L.: Current trends in the enhancement of fracture healing. J. Bone Joint Surg. 2001, 83, 157-164.
- 14.Inan M., Alat I., Gurses I., Kekilli E., Kutlu R., Eskin A., Aydin O. M., Bostan H., Yologlu S.: Induced angiogenesis with intramedullary direct current: experimental research. Am. J. Physiol. Heart Circ. Physiol. 2005, 288, H705-709.
- 15.Kenwright J., Goodship A.: Controlled mechanical stimulation in the treatment of tibial fractures. Clin. Orthop. 1988, 241, 36-47.
- 16.Lieberman J. R., Duluiski A., Einhorn T. A.: Current concepts review. The role of growth factors in the repair of bone. J. Bone Joint Surg. 2002, 84, 1032-1044.
- 17.Ohlsson C., Bengtsson B. A., Isaksson O. G., Andreassen T. T., Slootweg M. C.: Growth hormone and bone. Endocrine Rev. 1998, 19, 55-79.
- 18.Petrov N., Pollack S.: Comparative analysis of diffuse and stress induced nutrient transport efficiency in the lacunar-canalicular system of osteons. Biorheology 2003, 40, 347-353.
- 19.Rubin C., Lanyon L.: Regulation of bone mass by mechanical strain magnitude. Calcif. Tissue Int. 1985, 37, 411-417.
- 20.Ryaby J. T.: Clinical effects of electromagnetic and electric fields on fracture healing. Clin. Orthop. 1998, S335, 205-215.
- 21.Sieroñ A.: Zastosowanie pól magnetycznych w medycynie. a-medica press, Bielsko-Biała 2002, 132-135.
- 22.Skinner H.: Current diagnostic and treatment in orthopaedics. The McGraw- -Hill Companies, Irvine 2003, 81-82.
- 23.Służałek M.: Zastosowanie w stabilizatorze POLFIX wkrętów pokrytych warstwą diamentu nanokrystalicznego w leczeniu złamañ trzonu kości piszczelowej. Rozprawa doktorska, Śląska Akademia Medyczna, Katowice 2006.
- 24.Yasuda I., Noguchi K.: Dynamic callus and electric callus. J. Bone Joint Surg. 1955, 37A, 1292-1297.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-article-98806ee2-9d0b-4297-9a22-6c7fdd964fe5