Comparison of histological and ultrastructural changes in mice organs after supplementation with inorganic and organic selenium

• Autorzy: Tos-Luty S. , Obuchowska-Przebirowska D. , Latuszynska J. , Musik I. , Tokarska-Rodak M.
• Języki publikacji: EN

Abstrakty

EN

Two organic compounds of selenium, 4-o-totyl-selenosemicarbazide p-chlorobenzoic acid (chain compound) produced at the Chemistry Department of the University Medical School in Lublin, and one inorganic compound of sodium IV selenite (Na2SeO3) were used. The preparations were used per os in doses of 1 mg/kg body weight and 0.5 mg/kg body weight. The studies were conducted on female Swiss mice, covering seven groups of animals, i.e. 6 experimental and 1 control. Histopathologic changes were observed in liver, kidney, lung and heart. Ultrastructural changes were observed in liver and kidney. Our studies indicate a dose-dependent effect of selenium on histopathologic and ultrastructural changes. It is possible therefore, that the extent of excess of selenium exerts a greater influence on a cell than the form of supplemented selenium.

Słowa kluczowe

EN

oral application; mice; organ; occupational medicine; supplementation; histopathology; rat; organic selenium; occupational hazard; mouse; homeostasis; ultrastructural change; selenium; inorganic selenium; ultrastructure

• Wydawca: -
• Czasopismo: Annals of Agricultural and Environmental Medicine
• Rocznik: 2003
• Tom: 10
• Numer: 1
• Opis fizyczny: p.87-91,fig.

Twórcy

autor

Tos-Luty S.

• Institute of Agricultural Medicine, P.O.Box 185, 20-950 Lublin, Poland

autor

Obuchowska-Przebirowska D.

autor

Latuszynska J.

autor

Musik I.

autor

Tokarska-Rodak M.

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