Conformational properties of N',N'-dimethylamides of N-acetyldehydroalanine and N-acetyl-[Z]-dehydrophenylalanine

• Autorzy: Siodlak D. , Broda M.A. , Rzeszotarska B. , Koziol A.E. , Dybala I.
• Języki publikacji: EN

Abstrakty

EN

Conformational preferences of Ac-ΔAla-NMe2 and Ac-(Z)-ΔPhe-NMe2 were studied and compared with those of their monomethyl counterparts as well as with those of their saturated analogues. X-Ray data and energy calculations revealed a highly con­servative conformation of the dehydro dimethylamides, which is located in a high-en­ergy region of the Ramachandran map.

Słowa kluczowe

EN

phenylalanine derivative; conformational property; X-ray crystallography; N-acetyl-[Z]-dehydrophenylalanine; beta-dehydroamino acid; N',N'-dimethylamide; alpha-dehydroamino acid; alanine; N-acetyldehydroalanine

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 4
• Opis fizyczny: p.1179-1183,fig.

Twórcy

autor

Siodlak D.

• University of Opole, 48 Oleska str., 45-052 Opole, Poland

autor

Broda M.A.

autor

Rzeszotarska B.

autor

Koziol A.E.

autor

Dybala I.

Bibliografia

• 1.Palmer, D.E., Pattaroni, Ch., Nunami, K., Chadha, R.K., Goodman, M., Wakamiya, T., Fukase, K., Horimoto, S., Kitazawa, M., Fujita, H., Kubo, A. & Shiba, T .(1992). J. Am. Chem. Soc. 114, 5634-5642.
• 2.Souhassou, M., Lecomte, C., Ghermani, N.-E., Rohmer, M.M., Wiest, R., Benard, M. & Blessing, R.H. (1992) J. Am. Chem. Soc. 114, 2371-2382.
• 3.Zimmerman, S.S., Pottle, M.S., Nemethy, G. & Scheraga,H.A. (1977) Macromolecules 10, 1-9. MEDLINE
• 4.Dunitz, J.D. & Winkler, F.K. (1975) Acta Crystallogr. B31, 251-263.