Czasopismo
Tytuł artykułu
Warianty tytułu
Influence of calcitonin gene-related peptide [CGRP] on blood flow in the porcine uterine artery
Języki publikacji
Abstrakty
The aim of the study was to determine the effect of calcitonin gene-related peptide (CGRP) on blood flow in the uterine artery of immature and mature pigs, as well as the interaction between CGRP and its C-terminal fragment [Tyr0]CGRP(28-37) in the uterine artery of mature animals in vivo. It was indicated that CGRP relaxes the uterine artery to a similar degree in both immature and mature pigs. [Tyr0]CGRP(28-37) administered as an intra-arterial bolus injection neither affected blood pressure nor antagonized the actions of CGRP. It was concluded that CGRP-induced relaxation of the porcine uterine artery occurs independently of steroid hormone concentrations and that [Tyr0]CGRP(28-37) does not affect CGRP activity.
Wydawca
Czasopismo
Rocznik
Tom
Numer
Strony
1164-1166
Opis fizyczny
s.1164-1166,rys.,bibliogr.
Twórcy
autor
- Uniwersytet Warminsko-Mazurski, ul.Oczapowskiego 13, 10-718 Olsztyn
autor
autor
autor
autor
autor
Bibliografia
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- 12.Fallgren B., Ekblad E., Edvinsson L.: Co-existence of neuropeptides and differential inhibition of vasodilator responses by neuropeptide Y in guinea pig uterine arteries. Neurosci. Lett. 1989, 100, 71-76.
- 13.Ford S. P., Stice S. L.: Effects of the ovary and conceptus on uterine blood flow in the pig. J. Reprod. Fertil. Suppl. 1985, 33, 83-90.
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- 16.Hulshof S. C., Dijkstra G., Van der Beek E. M., Bevers M. M., Figueiredo J. R., Beckers J. F., Van den Hurk R.: Immunocytochemical localization of vasoactive intestinal peptide and neuropeptide Y in the bovine ovary. Biol. Reprod. 1994, 50, 553-560.
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- 18.Maggi C. A., Rovero P., Giuliani S., Evangelista S., Regoli D., Meli A.: Biological activity of N-terminal fragments of calcitonin gene-related peptide. Eur. J Pharmacol. 1990, 179, 217-219.
- 19.Markiewicz W., Jaroszewski J. J., Barszczewska B., Malanka T., Majewski M.: The distribution and influence of calcitonin gene-related peptide (CGRP) on the perfusion pressure in the isolated ovarian artery in the pig. Folia Morphol. 2004, 63, 99-101.
- 20.Markiewicz W., Jaroszewski J. J., Bossowska A., Majewski M.: NPY: its occurrence and relevance in the female reproductive system. Folia Histochem. Cytobiol. 2003, 41, 183-192.
- 21.Mione M. C., Cavallotti C., Burnstock G., Amenta F.: The peptidergic innervation of the guinea pig uterine artery in pregnancy. Basic Appl. Histochem. 1988, 32, 153-159.
- 22.Nelson S. H., Suresh M. S., Dehring D. J., Johnson R. L.: Relaxation by calcitonin gene-related peptide may involve activation of K+ channels in the human uterine artery. Eur. J. Pharmacol. 1993, 242, 255-261.
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Typ dokumentu
Bibliografia
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