Siatkowka, jadro skrzyzowania oraz szyszynka jako elementy zegara biologicznego ssakow

• Autorzy: Lewczuk B

Warianty tytułu

EN

Retina, suprachiasmatic nucleus and the pineal gland as components of the mammalian biological clock

• Języki publikacji: PL

Abstrakty

EN

The article presents the most important mechanisms related to the functioning of the retina, the suprachiasmatic nucleus (SCN) and the pineal gland as components of the mammalian biological clock. Environmental light influences the biological clock in mammals via light-sensitive, retinal ganglion cells containing a photo pigment - melanopsin. The axons of these neurons form the retionohypothalamic tract, which terminates in SCN. Neurons located in SCN generate cyclic, circadian changes in their activity due to a system of clock genes, the transcription of which is mutually controlled by an auto regulatory feedback loop. Glutamate and pituitary adenylate cyclase activating peptide (PACAP) - neurotransmitters released from terminals of the retionohypothalamic tract, synchronize the activity of the SCN neurons with environmental light conditions. The neuronal cells located in SCN influence the pineal activity via a paired, mulisynaptic pathway, composed of neurons of the paraventricular nucleus, the intermediolateral nuclei of the spinal cord and the cranial cervical ganglion, which supply the pineal gland with sympathetic nerve fibers. Norepinephrine, released from these fibers at night, stimulates melatonin secretion. The intracellular mechanisms controlling melatonin synthesis in the pinealocytes have significant variations between species, which accounts for differences in the diurnal patterns of pineal hormone secretion.

Słowa kluczowe

PL

zegar biologiczny; sekrecja; szyszynka; ssaki; siatkowka [anat.]; regulacja sekrecji; jadro skrzyzowania wzrokowego; melatonina

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 05
• Strony: 506-511
• Opis fizyczny: s.506-511,rys.,bibliogr.

Twórcy

autor

Lewczuk B

• Uniwersytet Warminsko-Mazurski w Olsztynie, ul.Oczapowskiego 13, 10-713 Olsztyn

Bibliografia

• 1.Bae K., Jin X. W., Maywood E. S., Hastings M. H., Reppert S. M., Weaver D. R.: Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 2001, 30, 525-536.
• 2.Bargiello T. A., Jackson F. R., Young M. W.: Restoration of circadian behavioural rhythms by gene transfer in Drosophila. Nature 1984, 312, 752-754.
• 3.Coon S. L., Roseboom P. H., Baler R., Weller J. L., Namboodiri M. A. A., Koonin E. V., Klein D. C.: Pineal serotonin N-acetyltransferase: expression, cloning and molecular analysis. Science 1995, 270, 1681-1683.
• 4.Coon S. L., Weller J. L., Korf H. W., Namboodiri M. A., Rollag M., Klein D. C.: cAMP regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87) - A new cell line (1E7) provides evidence of intracellular AANAT activation. J. Biol. Chem. 2001, 276, 24097-24107.
• 5. Foster R. G., Provencio I., Hudson D., Fiske S., De Grip W., Menaker M.: Circadian photoreception in the retinally degenerate mouse (rd/rd). J. Comp. Physiol. A, 1991, 169, 39-50.
• 6.Freedman M. S., Lucas R. J., Soni B., Schantz M., von Muñoz M., David-Gray Z., Foster R. G.: Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors. Science 1999, 284, 502-504.
• 7.Ganguly S., Gastel J., Weller J. L., Schwartz C., Jaffe H., Namboodiri M. A. A., Coon S. L., Hickman A. B., Rollag M., Obsil T., Beauverger P., Ferry G., Boutin J. A., Klein D. C.: Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. Proc. Natl. Acad. Sci. USA 2001, 98, 8083-8088.
• 8.Gastel J. A., Roseboom P. H., Rinaldi P. A., Weller J. L., Klein D. C.: Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation. Science 1998, 279, 1358-1360.
• 9.Gauer F., Poirel V. J., Garidou M. L., Simonneaux V., Pevet P.: Molecular cloning of the arylalkylamine N-acetyltransferase and daily variations of its mRNA expression in the Syrian hamster pineal gland. Brain. Res. Mol. Brain Res. 1999, 71, 87-95.
• 10.Gillette M. U., Mitchell J. W.: Signaling in the suprachiasmatic nucleus: selectively responsive and integrative. Cell Tissue Res. 2002, 309, 99-107.
• 11.Gooley J. J., Lu J., Chou T. C., Scammell T. E., Saper C. B.: Melanopsin in cells of origin of the retinohypothalamic tract. Nat. Neurosci. 2001, 4, 1165.
• 12.Hannibal J.: Neurotransmitters of the retino-hypothalamic tract. Cell Tissue Res. 2002, 309, 73-88.
• 13.Hannibal J., Ding J. M., Chen D., Fahrenkrug J., Larsen P. J., Gillette M. U., Mikkelsen J. D.: Pituitary adenylate cyclase-activating peptide (PACAP) in the retinohypothalamic tract: a potential daytime regulator of the biological clock. J. Neurosci. 1997, 17, 2637-2644.
• 14.Hannibal J., Fahrenkrug J.: Melanopsin containing retinal ganglion cells are light responsive from birth. Neuroreport. 2004, 15, 2317-2320.
• 15.Ho A. K., Chik C. L.: Post-receptor mechanism in dual receptors regulation of second messengers in rat pineal gland. Progr. Clin. Biol. Res. 1990, 342, 139-145.
• 16.Howell H. E., Morgan P. J.: b-Adrenergic stimulation increases cAMP and melatonin production in ovine pinealocyte cultures. J. Pineal Res. 1991, 10, 122-129.
• 17.Kume K., Zylka M. J., Sriram S., Shearman L. P., Weaver D. H., Jin X., Maywood E., Hastings M. H., Reppert S. M.: mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 1999, 98, 193-205.
• 18.Larsen P. J., Enquist L. W., Card J. P.: Characterization of the multisynaptic neuronal control of the rat pineal gland using viral transneuronal tracing. Eur. J. Neurosci. 1998, 10, 128-145.
• 19.Lewczuk B.: Mechanizmy adrenergicznej regulacji sekrecji melatoniny w szyszynce świni - badania in vitro. Praca hab., Rozprawy i monografie 2002, 60, Wyd. UWM w Olsztynie.
• 20.Lewczuk B., Prusik M., Przybylska-Gornowicz B.: Effects of transcription and translation inhibitors on norepinephrine-evoked increase in melatonin secretion in the pineal glands of three mammalian species (rat, sheep and pig): a kinetic study using the superfusion culture. Abstracts X Congress of European Pineal and Biological Rhythm Society, Frankfurt am Main, 2005, s. 122.
• 21.Maronde E., Pfeffer M., Olcese J., Molina C. A., Schlotter F., Dehghani F., Korf H. W., Stehle J. H.: Transcription factors in neuroendocrine regulation: rhythmic changes in pCREB and ICER levels frame melatonin synthesis. J. Neurosci. 1999, 19, 3326-3336.
• 22.Maronde E., Pfeffer M., von Gall C., Dehghani F., Schomerus C., Wicht H., Kroeber S., Olcese J., Stehle J. H., Korf H. W.: Signal transduction in the rodent pineal organ, [w:] Olcese J. (red.): Melatonin After Four Decades. Kluwer Academic/Plenum Publishers, New York 2000, 109-132.
• 23.Moore R. Y., Speh J. C., Leak R. K.: Suprachiasmatic nucleus organization. Cell Tissue Res. 2002, 309, 89-98.
• 24.Okamura H., Yamaguchi S., Yagita K.: Molecular machinery of the circadian clock in mammals. Cell Tissue Res. 2002, 309, 47-56.
• 25.Panda S., Provencio I., Tu D. C., Pires S. S., Rollag M. D., Castrucci A. M., Pletcher M. T., Sato T. K., Wiltshire T., Andahazy M., Kay S. A., Van Gelder R. N., Hogenesch J. B.: Melanopsin is required for non-image-forming photic responses in blind mice. Science 2003, 301, 525-527.
• 26.Provencio I., Jiang G., De Grip W. J., Hayes W. P., Rollag M. D.: Melanopsin: An opsin in melanophores, brain, and eye. Proc. Natl. Acad. Sci. USA 1998, 95, 340-345.
• 27.Provencio I., Rodriguez I. R., Jiang G., Hayes W. P., Moreira E. F., Rollag M. D.: A novel human opsin in the inner retina. J. Neurosci. 2000, 20, 600-605.
• 28.Reiter R. J.: Pineal melatonin: Cell biology of its synthesis and of its physiological interactions. Endocrine Rev. 1991, 12, 151-180.
• 29.Roseboom P. H., Coon S. L., Baler R., McCune S. K., Weller J. L., Klein D. C.: Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland. Endocrinology 1996, 137, 3033-3045.
• 30.Rüppel R., Olcese J.: Bovine pinealocytes in monolayer culture: studies on the adrenergic regulation of melatonin secretion. Endocrinology 1991, 129, 2655-2662.
• 31.Schomerus C., Korf H. W., Laedtke E., Weller J. L., Klein D. C.: Selective adrenergic/cyclic AMP-dependent switch-off of proteasomal proteolysis alone switches on neural signal transduction: An example from the pineal gland. J. Neurochem. 2000, 75, 2123-2132.
• 32.Shearman L. P., Sriram S., Weaver D. R., Maywood E. S., Chaves I., Zheng B., Kume K., Lee C. C., van der Horst G. T. J., Hastings M. H., Reppert S. M.: Interacting molecular loops in the mammalian circadian clock. Science 2000, 288, 1013-1019.
• 33.Teclemariam-Mesbah R., Ter Horst G. J., Postema F., Wortel J., Buijs R. M.: Anatomical demonstration of the suprachiasmatic nucleus-pineal pathway. J. Comp. Neurol. 1999, 406, 171-182.
• 34.Tischkau S. A., Gallman E. A., Buchanan G. F., Gillette M. U.: Differential cAMP gating of glutamatergic signaling regulates long-term state changes in the suprachiasmatic circadian clock. J. Neurosci. 2000, 20, 7830-7837.
• 35.Vitaterna M. H., King D. P., Chang A.-M., Kornhauser J. M., Lowrey P. L., McDonald J. D., Dove W. F., Pinto L. H., Turek F. W., Takahashi J. S.: Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Nature 1994, 264, 719-725.