Ulcerative colitis in AKR mice is attenuated by intraperitoneally administered anandamide

• Autorzy: Engel M.A. , Kellermann C.A. , Rau T. , Burnat G. , Hahn E.G. , Konturek P.C.
• Języki publikacji: EN

Abstrakty

EN

Anti-inflammatory and anti-nociceptive properties of endocannabinoids and synthetic cannabinoid compounds were described previously. We studied effects of the endogenous cannabinoid anandamide (N-arachidonylethanolamine) in experimental colitis induced by TNBS (2,4,6-trinitrobenzene sulfonic acid) in AKR mice. A scoring system was used to describe clinical and macroscopic changes. Intraperitoneally administered anandamide significantly reduced experimental colitis, quantified by macroscopical and histological scoring systems as well as pro-inflammatory cytokine mRNA expression. We conclude that systemically administered anandamide attenuates TNBS colitis in mice, and that systemically active cannabinoid compounds might have therapeutic potential for the treatment of IBD.

Słowa kluczowe

EN

infiltration; ulcerative colitis; anandamine; colitis; mouse; inflammatory bowel disease; chronic inflammatory disorder; gastrointestinal tract; mast cell; eosinophilic granulocyte; mice; cannabinoid; neutrophil

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2008
• Tom: 59
• Numer: 4
• Strony: 673-689
• Opis fizyczny: p.673-689,fig.,ref.

Twórcy

autor

Engel M.A.

• University of Erlangen-Nuremberg, Ulmenweg 18, D-91054 Erlangen, Germany

autor

Kellermann C.A.

autor

Rau T.

autor

Burnat G.

autor

Hahn E.G.

autor

Konturek P.C.