Oxidative damage to DNA and antioxidant status in aging and age-related diseases

• Autorzy: Olinski R. , Siomek A. , Rozalski R. , Gackowski D. , Foksinski M. , Guz J. , Dziaman T. , Szpila A. , Tudek B.
• Języki publikacji: EN

Abstrakty

EN

Aging is a complex process involving morphologic and biochemical changes in single cells and in the whole organism. One of the most popular explanations of how aging occurs at the molecular level is the oxidative stress hypothesis. Oxidative stress leads in many cases to an age-dependent increase in the cellular level of oxidatively modified macromolecules including DNA, and it is this increase which has been linked to various pathological conditions, such as aging, carcinogenesis, neurodegenerative and cardiovascular diseases. It is, however, possible that a number of short-comings associated with gaps in our knowledge may be responsible for the failure to produce definite results when applied to understanding the role of DNA damage in aging and age-related diseases.

Słowa kluczowe

EN

neurodegenerative disease; biochemical change; single cell; pathological condition; base excision repair; reactive oxygen species; oxidative stress; aging; cardiovascular disease; oxidative DNA damage; age-related disease

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2007
• Tom: 54
• Numer: 1
• Opis fizyczny: p.11-26,fig.,ref.

Twórcy

autor

Olinski R.

• Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland

autor

Siomek A.

autor

Rozalski R.

autor

Gackowski D.

autor

Foksinski M.

autor

Guz J.

autor

Dziaman T.

autor

Szpila A.

autor

Tudek B.

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