Wplyw agonisty receptorow adrenegicznych beta2-clenbuterolu na mineralizacje kosci piszczelowej szczura w warunkach ustalonej osteopenii

• Autorzy: Radzki R P , Bienko M. , Kapica M. , Puzio I. , Dobrowolski P. , Filip R.

Warianty tytułu

EN

Effect of beta2-adrenergic receptor agonist clenbuterol on the mineralization of tibiae in rats with established osteopenia

• Języki publikacji: PL

Abstrakty

EN

The purpose of the study was to determine the effect β₂-adrenergic receptor agonist-clenbuterol on tibiae mineralization of female rats with established osteopenia. The experiments were conducted on 30 female 3-months-of-age Wistar rats with an initial body weight of about 250 g. The sham-operation - SHO (n=10) and bilateral ovariectomy - OVX (n=20) were performed. After 60 days of osteopenia induction the ovariectomized rats were divided into a group fed a standard diet (n=10) and a group that received a diet supplied with clenbuterol at a dose of 5 mg/kg. After 14 days of the experiment the tibiae was isolated and tested using a DEXA densitometer, peripheral quantitative computer tomography (pQCT) and three-point bending test. The obtained results proved that a 14 day period of clenbuterol treatment significantly increased mechanical properties content and mineral density, both planar (BMD) and volumetric (vTotBMD) of the tibiae of ovariectomized rats.

Słowa kluczowe

PL

szczury; clenbuterol; osteopenia; mineralizacja; kosc piszczelowa

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2006
• Tom: 62
• Numer: 07
• Strony: 824-826
• Opis fizyczny: s.824-826,tab.,bibliogr.

Twórcy

autor

Radzki R P

• Akademia Rolnicza, ul.Akademicka 12, 20-033 Lublin

autor

Bienko M.

autor

Kapica M.

autor

Puzio I.

autor

Dobrowolski P.

autor

Filip R.

Bibliografia

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