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2006 | 62 | 02 | 130-134
Tytuł artykułu

Mechanizm dzialania oraz zastosowanie kliniczne gestagenow w rozrodzie psow i kotow

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Warianty tytułu
Języki publikacji
PL
Abstrakty
EN
The aim of the paper was to present the clinical uses of gestagens most commonly used in dogs and cats. Gestagens are widely used in the treatment of small animals, with indications ranging from dermatological to behavioral problems. However their main use involves controlling the reproductive cycle which includes suppressing the ovarian cycle, suppressing abnormal sexual behavior - especially in male dogs, and supplementing endogenous progesterone in pregnancies potentially compromised by insufficient luteal function. The article reviews the research history of gestagens, their mechanisms, provides comments and considers suggested dosages as well as indications vs. contraindications for their use, as well as summarizing gestational compounds used in veterinary medicine. It also discusses clinical use of gestagens for the treatment of pseudo pregnancy, nymphomania, pituitary dwarfism inhibition, short anoestrus, hypertrophy of prostate, male hypersexuality and spermatogenesis.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
62
Numer
02
Strony
130-134
Opis fizyczny
s.130-134,bibliogr.
Twórcy
autor
  • Szkola Glowna Gospodarstwa Wiejskiego, ul. Nowoursynowska 159c, 02-787 Warszawa
autor
Bibliografia
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  • 3.Bigbee H. G., Hennessey P. W.: Megestrol acetate for postponing estrus in first-heat bitches. Vet. Med. Small Anim. Clin. 1977, 72, 1727-1730.
  • 4.Burke T. J., Reynolds H. A. Jr.: Megestrol acetate for estrus postponement in the bitch. J. Am. Vet. Med. Assoc. 1975, 167, 285-287.
  • 5.Capel-Edwards K., Hall D. E., Fellowes K. P., Vallance D. K.: Long-term administration of progesterone to the female Beagle dog. Tox. Appli. Pharmac. 1973, 24, 474-488.
  • 6.Colon J., Kimball M., Hansen B., Concannon P. W.: Effects of contraceptive doses of the gestagen megestrol acetate on luteinizing hormone and follicle-stimulating hormone secretion in female dogs. J. Reprod. Fertil. Suppl. 1993, 47, 519-521.
  • 7.Concannon P. W.: Contraception in the dog, [w:] The Veterinary Annual, No. 35, Blackwell Scientific, Oxford 1995, 35, 177-178.
  • 8.Conneely M. O., Mulac-Jericevic B., Lydon P. J.: Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids 2003, 68, 771-778.
  • 9.Cox J. E.: Gestagens in bitches: a review. J. Small. Anim. Pract. 1970, 11, 759-778.
  • 10.Dhaliwal G. K., England, G. C. W., Noakes D. E.: The influence of exogenous steroid hormones on steroid receptors, uterine histological structure and the bacterial flora of the normal bitch. Anim. Reprod. Sci. 1999, 56, 259-277.
  • 11.El Etreby M. F.: Effect of cyproterone acetate, levonorgestrel and progesterone on adrenal glands and reproductive organs in the beagle bitch. Cell Tissue Res. 1979, 200, 229-243.
  • 12.England G. C.: Effect of gestagens and androgens upon spermatogenesis and steroidogenesis in dogs. J. Reprod. Fertil. Suppl. 1997, 51, 123-138.
  • 13.England G.: Complications of treating presumed pseudopregnancy in pregnant bitches. Vet. Rec. 1998, 142, 369-371.
  • 14.Evans J. M., Jemmett J. E.: Megestrol acetate in veterinary medicine. Vet. Rec. 1975, 20, 505-505.
  • 15.Evans J. M., Sutton J. D.: The use of hormones, especially gestagens, to control oestrus in bitches. J. Reprod. Fertil. Suppl. 1989, 39, 163-173.
  • 16.Goyings L. S., Soko³owski J. H., Zimbelman R. G., Geng S.: Clinical, morphologic, and clinicopathologic findings in Beagles treated for two years with melengestrol acetate. Am. J. Vet. Res. 1977, 38, 1923-1931.
  • 17.Hart B. L.: Progestin therapy for aggressive behavior in male dog. J. Am. Vet. Med. Assoc. 1981, 178, 1070-1071.
  • 18.Hayden D. W., Barnes D. M., Johnson K. H.: Morphologic changes in the mammary gland of megestrol acetate-treated and untreated cats: a retrospective study. Vet. Pathol. 1989, 26, 104-113.
  • 19.Johnson A. N.: Comparative aspects of contraceptive steroids effects observed in beagle dogs. Toxicol. Pathol. 1989, 17, 389-395.
  • 20.Jurka P.: Ocena zmian zachodzących w macicy i jajnikach po stosowaniu steroidowych preparatów antykoncepcyjnych u suk. Praca dokt., SGGW, Warszawa 1999.
  • 21.Knol B. W., Egberink-Alink S. T.: Treatment of problem behaviour in dogs and cats by castration and progestagen administration: a review. Vet. Q. 1989, 11, 102-107.
  • 22.Knottenbelt C. M., Herrtage M. E.: Use of proligestone in the management of tree German shepherd dogs with pituitary dwarfism. J. Smal Anim. Pract. 2002, 43, 797-801.
  • 23.Kooistra H. S., Okkens A. C., Mol J. A., van Garderen E., Kirpensteijn J., Rijnberk A.: Lack of association of progestin-induced cystic endometrial hyperplasia with GH gene expression in the canine uterus. J. Reprod. Fertil. Suppl. 1997, 51, 355-361.
  • 24.Kooistra H. S., Voorhout G., Selman P. J.: Progestin-induced growth hormone (GH) production in the treatment of dogs with congenital GH deficiency. Dom. Anim. Endocrinol. 1998, 15, 515-518.
  • 25.Max A., Grabiec A.: Leczenie niepożądanych zachowañ samczych psów i kotów. Życie Wet. 2000, 75, 19-22.
  • 26.Mol J. A., van Garden E., Rytteman G. R.: New insights in the molecular mechanism of progestin-induced proliferation of mammary epithelium: induction of the local biosynthesis of growth hormone (GH) in the mammary glands of dogs, cats and humans. J. Steroid Biochem. Mol. Biol. 1996, 57, 67-71.
  • 27.Mulac-Jericevic B., Conneely O. M.: Reproductive tissue selective actions of progesterone receptors. Reproduction 2004, 128, 139-146.
  • 28.Olson P. N.: Disorders of the canine prostate gland. Proc. Annual Meeting of the Society for Theriogenology, Denver 1984, s. 46-59.
  • 29.Parez V., Sutton D.: Recent investigations of the efficacy and safety of proligestone for the prevention of oestrus and pseudopregnancy in bitches. J. Reprod. Fertil. Suppl. 1993, 47, 544-545.
  • 30.Romagnoli S., Concanon P. W.: Clinical use of progestins in bitches and queens: a review. IVIS 2003.
  • 31.Selman P. J., Mol J. A., Rutterman G. R., Rijnberk A.: Progestin treatment in the dog. Effect on the hypothalamic - pituitary - adrenocortical axis. Eur. J. Endocrinol. 1994, 131, 422-430.
  • 32.Selman P. J., Wolfswinkel J., Mol J. A.: Binding specificity of medroxyprogesterone acetate and proligestone for the progesterone and glucocorticoid receptor in the dog. Steril. 1996, 61, 133-137.
  • 33.Shimizu M., Tsutsui T., Kawakami E.: Effect of chlormadinone acetate pellet implantation on the volume of prostate peripheral blood level of sex hormones and semen quality in the dog. J. Vet. Med. Sci. 1995, 57, 395-399.
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Typ dokumentu
Bibliografia
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