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Myogenic factor 5 (myf-5) is the product of the MYF5 gene, belonging to the MyoD family. This transcription factor participates in the control of myogenesis. We identified 3 new mutations in the promoter region of the gene: A65C, C580T and C613T. The aim of this study was to evaluate the influence of the A65C transversion on gene expression. The analysis was conducted on 15 Polish Large White gilts. The relative content of MYF5 mRNA in m. longissimus dorsi did not differ significantly across MYF5 genotypes (AA, AC, CC). This result suggests that the A65C transversion may not play an important role in the expression of the MYF5 gene in analysed adult muscle but it abolishes a putative binding site for two transcription factors (CDP and HSF1) and creates such a site for Sp1.
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p.59-61,ref.
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autor
- Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Postepu 1, 05-552 Wolka Kosowska, Poland
autor
- Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Postepu 1, 05-552 Wolka Kosowska, Poland
autor
- Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Postepu 1, 05-552 Wolka Kosowska, Poland
autor
- Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Postepu 1, 05-552 Wolka Kosowska, Poland
autor
- National Research Institute of Animal Production, Experimental Station, Pawłowice, Poland
Bibliografia
- Chang TH, Primig M, Hadchouel J, Tajbakhsh S, Rocanourt D, Fernandez A, et al. 2004. An enhancer directs differential expression of the linked Mrf4 and Myf5 myogenic regulatory genes in the mouse. Dev Biol 269: 595-608.
- Chomczyński P, Sacchi N, 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate- phenol-chloroform extraction. Anal Biochem 162: 156-159.
- Kawasaki ES, 1990. Sample preparation from blood, cells and other fluids. In: Innis MA, Gelfand DH, Sninsky JJ, White TJ, eds. PCR Protocols: A guide to methods and applications. Acad Press, New York: 3-12.
- MacLeod D, Charlton J, Mullins J, Bird AP, 1994. Spl sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. Gen Dev 8: 2282-2292.
- Te Pas MFW, 2004. Candidate genes for meat production and meat quality - the MRF genes. Anim Sci Pap Rep 22: 115-118.
- Te Pas MFW, Harders FL, Soumillion A, Born L, Buist W, Meuwissen THE, 1999. Genetic variation at the porcine MYF-5 gene locus: Lack of association with meat production traits. Mamm Genome 10: 123-127.
- Te Pas MFW, Verburg FJ, Gerritsen CLM, De Greef KH, 2000. Messenger ribonucleic acid expression of the MyoD gene family in muscle tissue at slaughter in relation to selection for porcine growth rate. J Anim Sci 78: 69-77.
- Te Pas MFW, Visscher AH, 1994. Genetic regulation of meat production by embryonic muscle formation: a review. J Anim Breed Genet 111: 404-412.
- Urbański P, Kurył J, 2004. New SNPs in the coding region and 5’ flanking regions of the porcine MYODI (MYF3) and MYF5 genes. J Appl Genet 45: 325-329.
- Zammit PS, Carvajal JJ, Golding JP, Morgan JE, Summerbell D, Zolnerciks J, Partridge TA, Rigby PWJ, Beauchamp JR, 2004. Myf5 expression in satellite cells and spindles in adult muscle is controlled by separate genetic elements. Dev Biol 273: 454-465.
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Bibliografia
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bwmeta1.element.agro-article-7eb31409-774a-4c54-96c6-3e576273c281