Angiotensins II and IV modulate adrenocortical cell proliferation in ovariectomized rats

• Autorzy: Siejka A. , Melen-Mucha G. , Mucha S.A. , Pawlikowski M.
• Języki publikacji: EN

Abstrakty

EN

Effects of angiotensins II (AngII), angiotensin IV (AngIV, 3-8 fragment of angiotensin II) and losartan (an antagonist of angiotensin receptor type 1) on the proliferation of adrenocortical cells in ovariectomized rats have been studied. The incorporation of bromodeoxyuridine (BrdU) into cell nuclei was used as an index of cell proliferation. AngIV decreased BrdU labeling index mainly in the reticularis zone and losartan (Los) was able to partially reverse this inhibitory effect of AngIV. AngII had no effect on the adrenocortical cell proliferation when given alone, however Los given simultaneously diminished BrdU incorporation into nuclei of glomerulosa and reticularis zones as compared with AngII. These findings suggest that AngII and AngIV modulate adrenocortical cell proliferation in ovariectomized rats.

Słowa kluczowe

EN

cell proliferation; adrenal cortex; ovariectomy; rat; angiotensin IV; angiotensin II

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2006
• Tom: 57
• Numer: 3
• Opis fizyczny: p.451-461,fig.,ref.

Twórcy

autor

Siejka A.

• Medical University of Lodz, Dr.Sterling 3 Street, 91-425 Lodz, Poland

autor

Melen-Mucha G.

autor

Mucha S.A.

autor

Pawlikowski M.