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Liczba wyników
2007 | 54 | 4 | 703-715
Tytuł artykułu

Hepatitis C - new developments in the studies of the viral life cycle

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Hepatitis C virus (HCV) is a causative agent of chronic liver disease leading tocirrhosis, liver failure and hepatocellular carcinoma. The prevalence of HCV is estimated as 3% of the world population and the virus is a major public health problem all over the world. For over 16 years, since HCV had been discovered, studies of the mechanisms of the viral life cycle and virus-host interactions have been hampered by the lack of a cell culture system allowing the virus to be grown in laboratory conditions. However, in recent years some new model systems to study HCV have been developed. The major breakthrough of the last two years was the cell culture system for maintaining the virus in an adapted hepatocyte-derived cell line. This review describes the techniques and applications of most of the in vitrosystems and animal models currently used for working with hepatitis C virus
Wydawca
-
Rocznik
Tom
54
Numer
4
Strony
703-715
Opis fizyczny
p.703-715,fig.,ref.
Twórcy
  • University of Gdansk and Medical University of Gdansk, Kladki 24, 80-822 Gdansk, Poland
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