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Sulphide-2-chloroethyl-3-chloropropyl is an alkylating agent. It posssesses mutagenic and carcinogenic properties, participates in oxidative processes and can induce lipid peroxidation.The aim of our investigation was to define antioxidative activity of natural anthocyanins after single experimental intoxication with sulphide-2-chloroethyl-3-chloropropyl in mice. Catalase activity in hemolysate, thiobarbituric acid reacting substances (TBARS) concentration in hemolysate and selected organs were determined. The study confirms increased lipid peroxidation as a result of sulphide-2-chloroethyl-3-chloropropyl intoxication, but natural anthocyanines derived from Aronia Melanocarpa also seem to play a protective role as an antioxidative agent.
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p.339-341,ref.
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- Medical University, Pl.Gen.J.Hallera 1, 90-647 Lodz, Poland
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Bibliografia
- 1. WALKER J.G. Intrastrand bifunctional alkylation DNA in mammalian cells treated with mustard gas. Can. J. Biochem. 49, 332, 1971.
- 2. SPENCER G.E., SPRINGER N., SPENCER P.S. In vitro neurotoxic and DNA-damaging properties of nitrogen mustard. J.Appl.Toxicol. 20, suppl.1, S35, 2001.
- 3. HUSAIN K., DUBE S.N., SUGENDRAN K., DAS GUPTA S., SOMANI S.M. Effect of topically applied sulphur mustard on antioxidant enzymes in blood cells and body tissues of rats. J.Appl.Toxicol. 16(3), 245, 1996.
- 4. DABROWSKA M.I, BECKS L.L., LELLI J.L., LEVEE M.G., HINSHAW D.B. Sulphur mustard induces apoptosis and necrosis in endothelial cells. Toxicol.Appl.Pharmacol. 141, 568,1996.
- 5. VINDEVOGHEL L., CAPDEVILA C., BINDER P., ADOLPHE M. Cytotoxicity of sulphur mustard on a human keratinocyte cell line: direct effects compared to conditioned-medium effects. Toxicol.Lett. 71, 227,1994.
- 6. GHANEI M., VASOGHI A.A. An epidemiologic study for chronic myelocytic leukemia in war victims exposed to mustard gas. Environ. Health Perspect. 110 (5), 519, 2002.
- 7. ELSAYED M.S., OMAYE S.T., KLAIN G.J., KATE D.W. Free radical-mediated lung response to the monofunctional sulphur mustard butyl 2-chloroethyl sulphide after subcutaneous injection. Toxicology 72, 153, 1992.
- 8. STRZELCZYK M., NIEDWOROK J., RUTKOWSKI M., DUBIECKI K., KLEM J., PUCZKOWSKI S., WOŁKANIN P., KOPF M., BORKOWSKA H., ZAKRZEWSKA J. Badania toksyczności sulfidu 2-chloroetylo-3-chloropropylowego (Cleps)-substancji czynnej w nowych preparatach leczniczych-Psoriased sulfiryd ulcer-Cleps. XXIX Zjazd Polskiego Towarzystwa Biochemicznego Wrocław 1993.
- 9. BEERS R.F., SIZER J.W. Spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J.Biol.Chem. 195, 133, 1952.
- 10. BUEGE J.A., AUNT S.D. Microsomal lipid peroxidation. Methods Enzymol. 52, 302,1978.
- 11. KENNEDY T.P., RAO N.V., MICHAEL J.R. Ibuprofen prevents oxidant lung injury and in vitro lipid peroxidation by chelating iron. J.Clin.Invest. 86, 1565, 1990.
- 12. YU B.P. Cellular defenses against damage from reactive oxygen species. Physiol.Rev. 74, 139, 1994.
- 13. SUN Y. Free radicals, antioxidant enzymes and carcinogenesis. Free Rad.Biol.Med. 8, 583, 1990.
- 14. HALLIWELL B., GUTTERIDGE J.M.C. Free radicals and antioxidant protection: mechanism and significance in toxicology and diseases. Hum.Toxicol. 7, 7, 1988.
- 15. DACRE J.C., GOLDMAN M. Toxicology and pharmacology of the chemical warfare agent sulfur mustard. Pharmacol.Rev. 2 (48), 289, 1996.
- 16. VIJAYARAGHAVAN R., SUGENDRAN K., PANT S.C., HUSIAN K., MALHOTRA R.C. Dermal intoxication of mice with bis(2-chloroethyl)sulphide and the protective effect of flavonoids. Toxicology 69, 35, 1991.
- 17. BALL C.R. Estimation and identification of thiols in rat spleen after cysteine or glutathione treatment: relevane to protection against nitrogen mustard. Nbiochem.Pharmacol. 15, 809, 1966.
- 18. WILDE P.E., UPSHALL D.G. Cysteine esters protect cultured rodent lung slices from sulphur mustard. Human Experiment.Toxicology, 13, 743, 1994.
- 19. WOLNIAK M.: Mechanisms of antioxidative action of anthocyanins. Farm. Pol. 20, 931, 2002.
- 20. WAWER I.:Antocyjanidyny- struktura i działanie antyoksydacyjne. Farm. Pol. 15, 728, 2001.
- 21. SATO M., BAGCHI D., TOSAKI A. Grape seed proanthocyanidin reduces cardiomiocyte apoptosis by inhibiting ischemia/reperfusion- induced activation of JNK-1 and CJUN. Free.Radic.Biol. Med. 15, 2001.
- 22. AMIR A., CHAPMAN S., KADAR T., GOZEZ Y., SAHAR R., ALLON N. Sulfur mustard toxicity in macrophages. Effect of dexamethasone. J.Appl.Toxicol. 20, suppl.20, S51, 2001.
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Bibliografia
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