Small is beautiful: major modifications in DNA structure or dynamics by small substituents or ligands

Guschlbauer, W

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Artykuł - szczegóły

Czasopismo

Acta Biochimica Polonica

1996 | 43 | 1 |

Tytuł artykułu

Small is beautiful: major modifications in DNA structure or dynamics by small substituents or ligands

Autorzy

Guschlbauer W.

Warianty tytułu

Języki publikacji

Abstrakty

This short review assembles the contributions of the author's laboratory to the structural aspects of DNA. DNA was modified by small ligands and/or substituents. There are three aspects to this work: a) Protonation of guanosine and DNA and the formation of triple- and quadruple-strands of guanosine, its nucleotides, their polymers and DNA. b) Substitution of the 2'-position of deoxyribose by the most polar atom, fluorine: studies on 2'-deoxy-2'-fluoro-nucleosides, -nucleotides and their polymers, studied both by structural and biological methods. c) The effect of introducing the methyl group in the large groove of DNA: NMR studies of oligonucleotides containing N6-methylated adenine residues, and enzymatic and molecular biology work on Dam methylase are reported.

Słowa kluczowe

DNA structure substituent DNA large groove DNA methylation fluorine oligonucleotide 2'-deoxy-2'-fluoro-nucleoside protonated polynucleotide ligand N6-methylated adenine guanosine dynamics modification

Wydawca

Czasopismo

Acta Biochimica Polonica

Rocznik

1996

Tom

Numer

Opis fizyczny

p.77-94,fig.

Twórcy

autor

Guschlbauer W.

Service de Biochimie et Genetique Moleculaire, Bat.142, F-91191 Gif-sur-Yvette Cedex, France

Bibliografia

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