Czasopismo
Tytuł artykułu
Warianty tytułu
Języki publikacji
Abstrakty
The article describes the dynamics of changes in blood concentrations of the active substances present in the solution after its infusion to healthy cows in comparison to NaCI solution as well as the response of paretic cows to treatment with the new complex solution. Cows received a dose of 400 ml of Al solution (containing 8.4 g of Ca2+) intravenously. In healthy cows the average calcium concentration in blood serum prior to the test was 2.52 + 0.08 mmol/1 while 15 min. after the infusion the concentration rose to 3.10 ± 0.08 mmol/1 (p < 0.05) and magnesium concentration rose from 0.61 ± 0.05 to 1.39 ± 0.08 mmol/1 (p < 0.05). This experiment showed that elevated concentration of non-organic phosphates persisted 1 hour after infusion (p < 0.05). In the second phase of efficacy evaluation of the novel preparation Al on paretic cows the intravenous injection of 1 ml/kg of body weight of Al solution increased calcium concentration up to almost normal level (p < 0.05). The level of magnesium in serum 1 h after injection was statistically significantly higher by 63% (p < 0.05) and reached the physiologically normal concentration. 1 h after the infusion of test solution the level of phosphate was higher by 13% (p > 0.05). The rise was statistically not significant. Even though Al solution undoubtedly produced an increase in glucose concentration in the blood serum, due to wide dispersion of individual measurements and high standard deviation the increase (p > 0.05) in glucose concentration was found insignificant. Most of the treated paretic cows rose within 1-6 h after infusion of 400 ml of solution Al. No relapses were observed. A combination of different salts of calcium and magnesium, non-organic phosphates and glucose with analeptic substance mixed in one solution (Al solution) administered at a dose of 1 ml/kg of body weight raises concentrations of essential macroelements in blood serum of cattle and promotes improvement of paretic cows condition.
Wydawca
Czasopismo
Rocznik
Tom
Numer
Strony
17-23
Opis fizyczny
p.17-23,ref.
Twórcy
autor
- Lithuanian Veterinary Academy, Tilzes g.18, LT-47181 Kaunas, Lithuania
autor
autor
autor
Bibliografia
- Alban L, Agger JF (1996) Welfare in Danish dairy herds. Disease management routines in 1983-1994. Acta Vet Scan 37: 49-63.
- Andresen U, Kietzmann M, Andresen P (1999) Efficacy and tolerance of a calcium-magnesium-aspartate solution in the treatment of hypocalcemic parturient paresis in cows. Berl Munch Tierarztl Wochenschr 112: 400-406.
- Barlet JP, Davicco MJ (1992) 1-alfa-hydroxycholecalciferol for treatment of the downer cow syndrome. J Dairy Sci 75: 1253-1256.
- Bednarek D, Kondracki M, Grzqda M (2000) Magnesium and calcium in prophylaxis of parturient paresis in dairy cows. Med Weter 56: 367-371.
- Braun U, Jehle W, Siegwart N, Bleul U, Hassig M (2006) Behandlung der Gebarparese mit hochdosiertem Ka- lzium. Schweiz Arch Tierheilkd 148:121-129.
- Conigrave AD, Mun, Lok HC (2007) Aromatic 1-amino acids activate the calcium-sensing receptor. J Nutr 137: 1524S-1527S.
- Dabuzinskas S, Daunoras G, Matusevicius A (2004) Dynamics of concentrations of Ca, Mg, P and glucose after intravenous administration of complex solutions of calcium, magnesium, phosphorus, and glucose to rabbits. Vet Arhiv 74: 115-127.
- Daniel RCW, Moodie EW (1978) The effect of induced hy- pocalcaemia on the cardiac output and blood pressure of dairy cattle. Res Vet Sci 24: 380-382.
- Ebbesvik M (1993) Milk production in organic farming. Diet, feeding, health an yield. Meieriposten 82: 316-317.
- Fenvick DC (1988) The relationship between certain blood cations in cows with milk fever and both the state of consciousness and the position of cows when attended. Aust Vet J 65:374-375.
- Fenvick DC (1990) The relationship between certain blood constituents in cows with milk fever and the response following treatment with calcium borogluconate solutions. Aust Vet J 67:102-104.
- Gelfert CC, Alpers I, Dallmeyer M, Decker Huting A, Lesch S, Baumgartner W, Staufenbiel R (2007) Factors affecting the success rate of treatment of recumbent dairy cows suffering from hypocalcaemia. J Vet Med A 54: 191-198.
- Goff JP (2006) Mineral disorders of the transition period: origin and control. Proceedings of 24th World Buiatrics Congress 2006.
- Goff JP, Horst RL (1994) Calcium salts for treating hypocalcemia: carrier effects, acid-base balance, and oral versus rectal administration. J Dairy Sci 77: 1451-1456.
- Goff JP, Horst RL, Jardon PW, Borelli C, Wedam J (1996) Field trials of an oral calcium propionate paste as an aid to prevent milk fever in periparturient dairy cows. J Dairy Sci 79: 378-383.
- Groehn. YT, Erb HN, McCulloch CE, Saloniemi HS (1989) Epidemiology of metabolic disorders in dairy cattle: Association among host characteristics, disease and production. J Dairy Sci 72:1876-1885.
- Hebert SC (2006) Therapeutic use of calcimimetics. Ann Rev Med 57: 349-364.
- Higgins JJ, Sanchez WK, Guy MA (1996) An oral gel of calcium propionate plus propylene glycol is effective in elevating calcium and glucose levels in periparturient cows. J Dairy Sci 79 (Suppl 1): 130.
- Klimiene I, Mockeliunas R, Śpakauskas V (2005) Changes in blood, colostrum and urea biochemical parameters of cows after treatment with Glucosal. Z. u. mokslai 2: 48-53.
- Klimiene I, Śpakauskas V (2002) Reconstitution of the quantity of macroelements in blood of cows with milk fever by means of calcium preparations. Veterinarija ir zootechnika 18: 51-55.
- Klimiene I, Śpakauskas V, Jodkonis L (2001b) Blood biochemical and cytological indices in healthy and with os- teomalation or milk fever cows. Veterinarija ir zootechnika 14: 23-29.
- Klimiene I, Śpakauskas V, Śakys V (2001a) Biochemical blood serum parameters of dry, after calving and sick of milk fever cows. Veterinarija ir zootechnika 12: 18-24.
- Kvart C, Bjórsell KA, Larsson L (1982) Parturient paresis in the cow. Acta Vet Scand 23: 184-196.
- Malz C, Meyer C (1992) Neue Aspekte zur Pathogenese und Therapie der hypocalcamischen Gebarparese. Prakt Tierarzt 73: 507-515.
- Mockeliunas R, Sederevicius A, Śalomskas A, Mockeliuniene V, Maćiulskis P, Jacevicius E (2005) Analysis of disease prevalence and mortality of cattle in Lithuania. Veterinarija ir Zootechnika 32: 16-19.
- Mullen PA (1975) Clinical and biochemical responses to the treatment of milk fever. Vet Rec 97: 87-92.
- Mullen PA (1977) Milk fever: A case against polypharmacy solutions. Vet Rec 101: 405-407.
- Nagano N, Edward F, Nemeth EF (2005) Functional proteins involved in regulation of intracellular Ca for drug development: the extracellular calcium receptor and an innovative medical approach to control secondary hyperparathyroidism by calcimimetics. J Pharmacol Sci 97: 355-360.
- Oetzel GR (1996) Effects of calcium chloride gel treatment in dairy cows on incidence of periparturient diseases. J Am Vet Med Assoc 209: 958-961.
- Papich MG (2005) Drug compounding for veterinary patients. The AAPS Journal 7: 281-287.
- Pehrson B, Svensson C, Jonsson M (1998) A comparative study of the effectiveness of calcium propionate and calcium chloride for the prevention of parturient paresis. J Dairy Sci 81: 2011-2016.
- Riccardi D (2002) Cell surface, ion-sensing receptors. Exp Physiol 87:403-411.
- Ruât M, Petrel C (2004) Comment moduler l’activité du récepteur du calcium extracellulaire'? Medecine/Sciences 20: 980-985.
- Sansom BF, Mansion R, Vagg MJ (1983) Magnesium and milk fever. Vet Rec 112: 447-449.
- Schropp DM, Kovacic J (2007) Phosphorus and phosphate metabolism in veterinary patients. Journal of Veterinary Emergency and Critical Care 17: 127-134.
- Starevicius D, Matusevicius A, Spakauskas V (2007) Correlation between the level of Ca, P, Mg, glucose and parathormone in blood and the symptoms of paresis in cows. Veterinarija ir Zootechnika 38: 68-73.
- Stundzienè A, Sakys P, Spakauskas V, Baltuinikiené G (2000) Quantitative changes of calcium. Phosphorus and magnesium in blood serum of healthy and sick of milk fever cows. Veterinarija ir zootechnika. 8: 34-36.
- Whittem T (2004) AAVPT position paper regarding the evaluation of scientific manuscripts that involve the administration of compounded drugs to animals. Letter to the Editors. J Vet Pharmacol Therap 27: 537.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-article-5b241506-77a4-4c2d-b8e6-85863b92285e