Modulation of hemolytic properties of resorcinolic lipids by divalent cations

• Autorzy: Stasiuk M. , Kozubek A.
• Języki publikacji: EN

Abstrakty

EN

The effect of divalent cations in concentrations 10-9-10-3M upon the hemolysis of sheep erythrocytes induced by resorcinolic lipids was studied. It was demonstrated that the process of hemolysis is inhibited by divalent cations present in the incubation medium. The extent of inhibition is dependent on both type of the cation and hemolytic agent. In alkylresorcinol-induced hemolysis the most effective in protection of the cells were Zn2+ and Co2+ cations. Weaker protective action was observed for Cd2+ and Mn2+. Calcium ions, in all studied concentrations, were without marked effect on the level of relative hemolysis. Magnesium ions as well as Ba2+ in nanomolar concentrations were effective inhibitors of the lysis but this effect diminished at higher (millimolar) concentrations of these ions. When alkenylresorcinols were used as hemolysis-inducers no effective protection of erythrocytes by Ca2+, Ba2+ or Mg2+ was observed. Most effective in protection of cells against this amphiphile-induced lysis, similarly to their effect observed previously for various lytic agents, were cations of Zn2+, Co2+ and Cd2+. Mn2+ cations were intermediate, with respect to their protective potency.

Słowa kluczowe

EN

antihemolysis; lipid; cation; divalent cation; 5-n-alkylresorcinol; sheep erythrocyte; hemolysis

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 1996
• Tom: 01
• Numer: 2
• Opis fizyczny: p.189-198,fig.

Twórcy

autor

Stasiuk M.

• Wroclaw University, Przybyszewskiego 63-77, 51-148 Wroclaw, Poland

autor

Kozubek A.

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