Basic study on functional liposomes and their application

• Autorzy: Oku N.
• Języki publikacji: EN

Abstrakty

EN

Liposomes have been used as models of biomembranes and tools in the field of drug delivery systems. Liposomalization of various drugs has been revealed to enhance their efficacy and to reduce the side effect of the drugs. For site-specific delivery, intracellular targeting, and controlled release of drugs, many functional liposomes have been developed based on their nature as models of biomembranes. In this paper, preparation and characterization of three kinds of functional liposomes are presented, namely, thermosensitive liposomes for delivering macromolecules, pH-sensitive liposomes for cytosolic delivery of the encapsulated materials, and reticuloendothelial system (RES)-avoiding liposomes for passive targeting to tumor tissues. The actual usefulness of RES-avoiding liposomes modified with a uronic acid derivative, palmityl-D-glucuronide, for tumor imaging and therapy was demonstrated. Recently, a method to analyze liposomal trafficking in living animals, which is important in the use of liposomes as drug carriers, was developed by use of positron emission tomography. In this paper, liver accumulation of liposomes having various charges is shown.

Słowa kluczowe

EN

liposome; functional liposome; biomembrane; thermosensitive liposome; palmityl-D-glucuronide; cancer therapy; reticuloendothelial system; drug delivery system; tumour tissue; uronic acid; cancer diagnostics

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 1996
• Tom: 01
• Numer: 4
• Opis fizyczny: p.417-427,fig.

Twórcy

autor

Oku N.

• University of Shizuoka, 52-1 Yada, Shizuoka, 422, Japan

Bibliografia

• 1. Liposome Technology 2nd Edition (Gregoriadis, G., Ed.) CRC Press, 1992.
• 2. Oku, N. and Namba, Y. Crit. Rev. Ther. Drug Carrier Syst. 11 (1994) 231-270
• 3. Feigner, P.L., Gadek, T.R., Holm, M., Roman, R., Chan, H.W., Wenz, M., Northrop, J.P., Ringold, G.M. and Danielsen, M. Proc. Natl. Acad. Sci. USA 84 (1987) 7413-7417
• 4. Philip, R., Liggitt, D., Philip, M., Dasin, P. and Debs, R. J. Biol. Chem. 268 (1993) 16087-16090
• 5. Oku, N., Doi, K., Naruse, R. and Okada, S. Biochim. Biophys. Acta 1191 (1994) 389-391
• 6. Oku, N., Shibamoto, S., Ito, F., Gondo, H. and Nango, M. Biochemistry 26 (1987) 8145-8150
• 7. Hoekstra, D. Biochemistry 21 (1982) 2833-2840
• 8. Namba, Y., Sakakibara, T., Masada, M., Ito, F. and Oku, N. Chem. Lett. 1989 2145-2148
• 9. Mayer, L.D., Tai, L.C.L., Bally, M.B., Mitilenes, G.N., Ginsberg, R.S. and Cullis, P.R. Biochim. Biophys. Acta 1025 (1990) 143-151
• 10. Oku, N., Tokudome, Y., Tsukada, H. and Okada, S. Biochim. Biophys. Acta 1238 (1995) 86-90
• 11. Yatvin, M.B., Weinstein, J.N., Dennis, W.H. and Blumenthal, R. Science 202 (1978) 1290-1293
• 12. Iga, K., Hamaguchi, N., Igari, Y., Ogawa, Y., Toguchi, H. and Shimamoto, T. Int. J. Pharm. 57 (1989) 241-251
• 13. Connor, J., Yatvin, M.B. and Huang, L. Proc. Natl. Acad. Sci. USA 81 (1984) 1715-1718
• 14. Allen, T.M. and Chonn, A. FEBS Lett. 223 (1987) 42-46
• 15. Blume, G. and Cevc, G. Biochim. Biophys. Acta 1029 (1990) 91-97
• 16. Klibanov, A.L., Maruyama, K., Torchilin, V.P. and Huang, L. FEBS Lett. 268 (1990) 235-237
• 17. Namba, Y., Sakakibara, T., Masada, M., Ito, F. and Oku, N. Chem. Pharm. Bull. 38 (1990) 1663-1666
• 18. Oku, N. Namba, Y. and Okada, S. Biochim. Biophys. Acta 1126 (1992) 255-260
• 19. Oku, N., Namba, Y., Takeda, A. and Okada, S. Nucl. Med. Biol. 20 (1993) 407-712
• 20. Oku, N., Doi, K., Namba, Y. and Okada, S. Int. J. Cancer 58 (1994) 415-419
• 21. Tokudome, Y., Oku, N., Namba, Y. and Okada, S.Biochim. Biophys. Acta 1279 (1996) 70-74