The use of RP-HPTLC for modelling the hydrophobicity of fungicides

• Autorzy: Rozylo J. K. , Matysiak J. , Gumieniak A. , Niewiadomy A.
• Języki publikacji: EN

Abstrakty

EN

The retention behaviour of eighteen new antifungal dihydroxythiobenzanilides in a reversed-phase high performance thin-layer chromatographic system has been examined. Using water-acetone as the mobile phase, a linear relationship between the volume fraction of the organic solvent and the log k' values over a limited range was established for every solute. The physico-chemical parameters of these compounds were characterized by their hydrophobicity parameters log k'w, determined by extrapolation of the linear relationships for retention data in binary solvent systems to pure water. The good correlation obtained between log k' and S values of TLC equation supports the validity of the extrapolation technique. It was found that log k'w values of examined substances were correlated to their antimicrobial activity. The results suggest that log k'w might be an accurate model for assessment of the hydrophobicity of studied fungicides in biological systems.

Słowa kluczowe

EN

fungicide; determination; hydrophobicity; capacity factor; dihydroxythiobenzanilide; bioactive compound; reversed-phase thin-layer chromatography

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 1998
• Tom: 07
• Numer: 1
• Opis fizyczny: p.35-38,fig.,ref.

Twórcy

autor

Rozylo J. K.

• M.Curie-Sklodowska University, M.C.Sklodowska Sq.3, 20-031 Lublin, Poland

autor

Matysiak J.

autor

Gumieniak A.

autor

Niewiadomy A.