BonisteinTM (synthetic genistein), a food component in development for a bone health nutraceutical

• Autorzy: Ullmann U. , Bendik I. , Fluhmann B.
• Języki publikacji: EN

Abstrakty

EN

In the discussion of the risk-benefit relation of the hormone replacement therapy (HRT) for elder women phytochemicals with estrogenic activity received a great deal of attention. Phytoestrogens are naturally occurring compounds with structural similarity to 17b-estradiol. Especially genistein, an isoflavone most abundant in soy, possess a high and selective binding-affinity to the mammalian estrogen receptors. It has been found, that genistein exert in humans both: weak estrogenic and antiestrogenic effects, similar to the SERMs. Consequently, it was concluded, that genistein might provide an alternative to prevent postmenomausal bone-loss and ameliorate menopausal symptoms without side-effects similar to HRT. Pre-clinical experiments and results from clinical pilot studies with pure genistein confirmed its efficacy in these indications. Nevertheless, currently some open issues still exist to recommend its intake thoughtlessly. Bonistein™, pure synthetic genistein developed by DSM Nutritional Products, was tested extensively in appropriate models for bone health. A battery of toxicological studies was conducted to determine safe intake levels. In the early clinical development pharmacokinetic studies were performed in healthy volunteers and in postmenopausal women. Now large-scale studies are in preparation to investigate Bonistein™'s efficacy in postmenopausal bone-loss and climacteric syndrome.

Słowa kluczowe

EN

nutraceutical; functional food; hormone replacement therapy; genistein; pharmacokinetics; osteoporosis; bone health; menopause; Bonistein

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology. Supplement
• Rocznik: 2005
• Tom: 56
• Numer: 1
• Strony: 79-95
• Opis fizyczny: p.79-95,fig.,ref.

Twórcy

autor

Ullmann U.

• DSM Nutritional Products R and D Human Nutrition and Health, CH-4303 Kaiseraugst, Switzerland

autor

Bendik I.

autor

Fluhmann B.