Wplyw glinu i deferoksaminy na zawartosc biopierwiastkow u zwierzat doswiadczalnych poddanych intoksykacji glinem

• Autorzy: Fiejka M. , Dlugaszek M. , Graczyk A. , Slowikowska M. , Gorska P.
• Języki publikacji: PL

Abstrakty

PL

Oznaczono zawartość glinu oraz podstawowych biopierwiastków Ca, Mg, Zn, Cu, Fe w kości udowej i wątrobie zwierząt doświadczalnych, u których wywoływano kumulację glinu w tkankach, a następnie poddano działaniu deferoksaminy. Poszukiwano zależności między stężeniem glinu a poziomem biopierwiastków w badanych tkankach oraz zmiany wywołane działaniem deferoksaminy - chelatora glinu.

EN

To assess the effect of aluminium intoxication in tissues of experimental animals on Ca, Mg, Zn, Cu, and Fe concentration, aluminium nitrate was administered intraperitoneally to mice at a daily dose of 0.27 mMol/kg for 5 weeks. Concentration of Al, Ca, Mg, Zn, Cu, and Fe were analyzed by atomic absorption spectrometry. The Al content in liver and tibia was significantly higher in treated mice in comparison with control group. In Al loaded tissues the significant increase of all tested essential elements was found. To evaluate the results of DFO treatment on essential elements, mice received 6 times intraperitoneally 3.5 mMol/kg of DFO. This treatment had generally no effect on reduction of Al concentration in tibia and liver, as well as on changes in essential elements concentration.

Słowa kluczowe

PL

kosc udowa; zelazo; zwierzeta laboratoryjne; intoksykacja; biopierwiastki; watroba; kumulacja glinu; deferoksamina; tkanki zwierzece; wapn; glin; cynk; magnez; oznaczanie; miedz

• Wydawca: -
• Czasopismo: Medycyna Doświadczalna i Mikrobiologia
• Rocznik: 2001
• Tom: 53
• Numer: 1
• Strony: 101-106
• Opis fizyczny: s.101-106,tab.,bibliogr.

Twórcy

autor

Fiejka M.

• Panstwowy Zaklad Higieny, 00-791 Warszawa, ul.Chocimska 24

autor

Dlugaszek M.

autor

Graczyk A.

autor

Slowikowska M.

autor

Gorska P.

Bibliografia

• 1. Anghileri L, Maincent Ph, Thouvenot P. Aluminum distribution in tissues and effects on calcium metabolism . Ann Clin Lab Scie 1994; 24: 22-26.
• 2. Domingo J, Gomez M, Llobet JM. Citric, malic and succinic acids as possible alternatives to deferoxamine in aluminum toxicity. Clin Toxicol 1988; 26: 67-79.
• 3. Fiejka M, Fiejka E, Długaszek M. Effect of aluminium hydroxide administration on normal mice: tissue distribution and ultrastructural localization of aluminium in liver. Pharmacology & Toxicology 1996; 78: 123-28.
• 4. Finch JL, Bergfeld M, Martin K J i inni. The effects of discontinuation of aluminum exposure on aluminum - induced osteomalacia. Kidney Int 1986; 30: 318-24.
• 5. Moody JR Lindstrom RM. Selection and cleaning of plastic containers for storage of trace element samples. Anal Chem1977; 49; 2264-67.
• 6. Gomez M, Esparza JL , Domingo J L i inni. Aluminium distribution and excretion: a comparative study of a number of chelating agents in rats. Pharmacology & Toxicology 1998; 82: 295-300.
• 7. Jeffery EH, Abreo K, Burgess E i inni, Systemic aluminum toxicity: effects on bone, hematopoietic tissue, and kidney. J Toxicol Environ Health 1996; 48: 649-65.
• 8. Muller G, Burnel D, Gery A i inni. Element variations in pregnant and nonpregnent female rats orally intoxicated by aluminum lactate. Biol Trace Element Res 1993; 39: 211-19.
• 9. Sanchez D J, Gomez M, Llobet JM i inni. Effects of aluminium on the mineral metabolism of rats in relation to age. Pharmacology & Toxicology 1997; 80: 11-17.
• 10. Severson AR, Haut CF, Firling CE i inni. Infuence of short-term aluminum exposure on demineralized bone matrix induced bone formation. Arch Toxicol 1992; 66: 706-12.
• 11. Van der Voet GB, BrandsmaA, Heijink E i inni. Accumulation of aluminium in rat liver: association with constituents of the cytosol. Pharmacology & Toxicology 1992; 70: 173-76.
• 12. Yokel RA, Ackrill P, Burgess E i inni. Prevention and treatment of aluminum toxicity including chelation therapy: status and research needs. J Toxicol Environ Health 1996; 48: 667-83.