Wzajemne oddzialywanie toluenu i etanolu na metabolizm trichloroetylenu u szczurow

• Autorzy: Orlowski J. , Zielinska-Psuja B. , Dobrogowska J. , Kowalowka J.
• Języki publikacji: PL

Abstrakty

PL

Przebadano wydalanie kwasu trichlorooctowego i trichloroetanolu u szczurów poddanych pięciodniowym ekspozycjom na sam trichloroetylen (TRI) lub łącznie z toluenem po jednoczesnym podaniu etanolu. Wykazano, że oba związki zmieniają wydalanie głównych metabolitów trichloroetylenu.

EN

The elimination of trichloroacetic acid and trichloroethanol - the main metabolites of trichloroethylene - was studied in trichloroethylene-poisoned rats exposed to toluene and/or ethyl alcohol. The animals were exposed to trichloroethylene and toluene at 4.5 mmol/m3 air during six hours for five consecutive days. In the experiments which involved alcohol treatment, before each inhalation exposure the rats were given 1366 mg/kg body weight or 2732 mg/kg body weight ethanol by stomach tube. The metabolites of trichloroethylene were determined in urine collected after the exposure cycle. The results were statistically evaluated by the Tuckey test. Trichloroethylene metabolism has been shown to be significantly affected both by exposure to toluene alone and in combination with ethanol. Ethanol at 1366 mg/kg and 2732 mg/kg body weight decreased the elimination of trichloroacetic acid by about 34% and 46%, and of trichloroethanol by about 33% and 44%, respectively. Toluene reduced the elimination of trichloroacetic acid by about 30% and of trichloroethanol by about 34%. Under conditions of combined ethanol/toluene exposure, ethanol was more active than toluene to reduce the biotransformation of trichloroethylene to trichloroacetic acid. Toluene, when combined with ethanol, on the other hand, was more active to increase the elimination of trichloroethanol.

Słowa kluczowe

PL

zagrozenia zdrowia; trichloroetylen; metabolizm zwierzat; szczury; rozpuszczalniki; interakcje; zwierzeta laboratoryjne; kwas trichlorooctowy; etanol; toksykologia; trichloroetanol; toluen

EN

health hazard; trichloroethylene; animal metabolism; rat; solvent; interaction; laboratory animal; trichloroacetic acid; ethanol; toxicology; trichloroethanol; toluene

• Wydawca: -
• Czasopismo: Bromatologia i Chemia Toksykologiczna
• Rocznik: 1998
• Tom: 31
• Numer: 1
• Strony: 21-28
• Opis fizyczny: s.21-28,tab.,bibliogr.

Twórcy

autor

Orlowski J.

• Akademia Medyczna, 61-701 Poznan, ul.Fredry 10

autor

Zielinska-Psuja B.

autor

Dobrogowska J.

autor

Kowalowka J.

Bibliografia

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