Dynamics of changes in vascular endothelial growth factor (VEGF) expression and angiogenesis in stress-induced gastric ulceration in rats

• Autorzy: Malara B. , Josko J. , Tyrpien M. , Malara P. , Steplewska K.
• Języki publikacji: EN

Abstrakty

EN

Angiogenesis and VEGF play a major role in many repair processes such as healing of gastric ulceration.The present study was undertaken to assess the dynamics of changes in VEGF expression and angiogenesis in stress-induced gastric ulcers in rats. Acute gastric ulceration was induced using a water-immersion and restraint stress method. The VEGF expression, angiogenesis, size of area and depth of ulcers in gastric speciments were evaluated. The study shows that as early as one day after the development of ulcers there is a significant increase in both the expression of the VEGF protein and the number of newly formed microvessels, while an abrupt decrease in VEGF expression, observed on the fifth day, results in a decreased intensity of angiogenesis. Moreover, it has been demonstrated that the increase in VEGF expression and angiogenesis is accompanied by a reduction in the size of area and depth of stress-induced ulcers in rats. Six days after ulcer development both VEGF expression and angiogenesis return to normal levels.

Słowa kluczowe

EN

gastric ulcer; gastric ulceration; angiogenesis; expression; rat; stress; change dynamics; vascular endothelial growth factor

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2005
• Tom: 56
• Numer: 2
• Opis fizyczny: p.259-271,fig.,ref.

Twórcy

autor

Malara B.

• Silesia Medical School, Jordana 19, 41-808 Zabrze, Poland

autor

Josko J.

autor

Tyrpien M.

autor

Malara P.

autor

Steplewska K.