Wlasciwosci i chorobotworczosc toksyny beta-2 Clostridium perfringens

• Autorzy: Wasinski B

Warianty tytułu

EN

Properties and pathogenicity of beta-2 toxin produced by Clostridium perfringens

• Języki publikacji: PL

Abstrakty

EN

Described recently and investigated intensively over the last years, β2 toxin (CPB2) is produced by all toxino-types of Clostridium perfringens. The ability of CPB2 production was found in C. perfringens strains isolated from humans and many species of domestic animals and wildlife. The cpb2 gene encoding CPB2 was found in strains isolated from pathological cases and from animals without clinical symptoms. Apart from the detection of cpb2 presence, the demonstration of the expression of the gene is critical for laboratory diagnosis. CPB2 is postulated to participate in the development of differing in intensity enteric inflammatory changes. Its contribution to other C. perfringens toxins through the facilitating of their absorption is also suggested. Current data concerning regulation of cpb2 expression, CPB2 structure, its properties and presumptive role in pathogenesis of C. perfringens infections were reviewed in the present paper. Additionally some case reports concerning the putative role of CPB2 were reviewed.

Słowa kluczowe

PL

toksyny bakteryjne; wlasciwosci; chorobotworczosc; budowa; Clostridium perfringens; bakterie; toksyna beta-2

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2008
• Tom: 64
• Numer: 11
• Strony: 1275-1279
• Opis fizyczny: s.1275-1279,bibliogr.

Twórcy

autor

Wasinski B

• Panstwowy Instytut Weterynaryjny - Panstwowy Instytut Badawczy, Al.Partyzantow 57, 24-100 Pulawy

Bibliografia

• 1. Ahola H. S., Fossi M., Raunio-Saarnisto M., Korhonen T., Pajala A.: Clostridium perfringens type A with Beta 2 toxin gene in porcine diarrhea. A case report. Proc. 19th IPVS Congress, Copenhagen 2006, 2, 324.
• 2. Ashfalk A., Műller W.: Clostridium perfringens toxin types from wild-caught Atlantic cod (Gadus morhua L.) determined by PCR and ELISA. Can. J. Microbiol. 2002, 48, 365-368.
• 3. Ashfalk A., Műller W.: Clostridium perfringens toxin types in hooded seals in the Greenland Sea, determined by PCR and ELISA. J. Vet. Med. B 2001, 48, 765-769.
• 4. Ashfalk A., Valentin-Weigand P., Mûller W., Goethe R.: Toxin types of Clostridium perfringens isolated from free-ranging, semi-domesticated reindeer in Norway. Vet. Rec. 2002, 151, 210-213.
• 5. Augustynowicz E.: Molekularne podstawy patologicznego działania Clostridium perfringens. Post. Mikrobiol. 1999, 38, 257-275.
• 6. Bacciarini L. N., Boerlin P., Straub R., Frey J., Grone A.: Immunohistochemical localization of Clostridium perfringens β2-toxin in the gastrointestinal tract of horses. Vet. Pathol. 2003, 40, 376-381.
• 7. Bacciarini L. N., Pagan O., Frey J., Grone A.: Clostridium perfringens β2 toxin in an African elephant (Loxodonta africana). Vet. Rec. 2001, 149, 618-620.
• 8. Bueschel D. M., Jost B. H., Billington S. J., Trinh H. T., Songer J. G.: Prevalence of cpb2, encoding β2 toxin, in Clostridium perfringens field isolates: correlation of genotype with phenotype. Vet. Microbiol. 2003, 94, 121-129.
• 9. Choi Y. K., Kang M. S., Yoo H. S., Lee D. Y., Lee H. C., Kim D. Y.: Clostridium perfringens type A myonecrosis in horse in Korea. J. Vet. Med. Sci. 2003, 65, 1245-1247.
• 10. Dray T.: Clostridium perfringens type A and beta2 toxin associated with eneterotoxemia in a 5-week old goat. Can. Vet. J. 2004, 45, 251-253.
• 11. East L. M., Savage C. J., Traub-Dargatz J. L., Dickinson C. E., Ellis R. P.: Enterocolitis with Clostridium perfringens infection in neonatal foals: 54 cases (1988-1997). J. Am. Vet. Assoc. 1998, 212, 1751-1756.
• 12. Engström B. E., Fermer C., Lindberg A., Saarinen E., Baverud V., Gunnarsson A.: Molecular typing of isolates of Clostridium perfringens from healthy and diseased poultry. Vet. Microbiol. 2003, 94, 225-235.
• 13. Fisher D. J.: Clostridium perfringens beta 2 toxin: a potential accessory toxin in gastrointestinal disease in of humans and domestic animals. Praca dokt., University of Pittsburgh 2006.
• 14. Fisher D. J., Miyamoto K., Harrison B., Akimoto S., Sarker M. R., McClane B. A.: Association of beta2 toxin production with Clostridium perfringens type A gastrointestinal disease isolates carrying a plasmid enterotoxin gene. Mol. Microbiol. 2005, 56, 747-762.
• 15. Garmory H. S., Chanter N., French N. P., Bueschel D., Songer J. D., Tiball R. W.: Occurrence of Clostridium perfringens β2-toxin amongst animals, determined using genotyping and subtyping PCR assays. Epidemiol. Infect. 2000, 124, 61-67.
• 16. Gholamiandekhordi A. R., Ducatelle R., Heyndrickx M., Haesebrouck F., Van Immerseel F.: Molecular and phenotypical characterization of Clostridium perfringens isolates from poultry flocks with different diseases status. Vet. Microbiol. 2006, 113, 143-152.
• 17. Gibert M., Jolivet-Reynaud C., Popoff M. R.: β2 toxin, a novel toxin produced by Clostridium perfringens. Gene 1997, 203, 65-73.
• 18. Gkiourtzidis K., Frey J., Bourtzi-Hatzopoulou E., Iliadis N., Sarris K.: PCR detection and prevalence of α-, β-, β2-, ε-, ι-, and entertoxin-genes in Clostridium perfringens isolated from lambs with clostridial dysentery. Vet. Microbiol. 2001, 82, 39-43.
• 19. Greco G., Madio A., Martella V., Campolo M., Corrente M., Buonavoglia D., Buonavoglia C.: Enterotoxemia associated with beta2 toxin-producing Clostridium perfringens type A in two Asiatic black bears (Selenarctos thibetanus). J. Vet. Diagn. Invest. 2005, 17, 186-189.
• 20. Herholz C., Miserez R., Nicolet J., Frey J., Popoff M., Gibert M., Straub R.: Prevalence of β2-toxigenic Clostridium perfringens in horses with intestinal disorders. J. Clin. Microbiol. 1999, 37, 358-361.
• 21. Jolivet-Renaud C., Popoff M. R., Vinit M. A., Ravisse P., Moreau H., Alouf J. E.: Enteropathogenicity of Clostridium perfringens beta toxin and other clostridial toxins. Zbl. Bakteriol. S, 1986, 15, 145-151.
• 22. Jost B. H., Billington S. J., Trinh H. T., Bueschel D. M., Songer J. G.: Atypical cpb2 genes, encoding beta 2 toxin in Clostridium perfringens isolates of nonporcine origin. Infect. Immun. 2005, 73, 652-656.
• 23. Jost B. H., Billington S. J., Trinh H. T., Songer J. G.: Association of genes encoding beta2 toxin and a collagen binding protein in Clostridium perfringens isolates of porcine origin. Vet. Microbiol. 2006, 115, 173-182.
• 24. Klassen H. L. B. M., Molkenboer M. J. C. H., Bakker J., Miserez R., Häni H., Frey J., Popoff M. R., van den Bosh J. F.: Detection of the β2 toxin gene of Clostridium perfringens in diarrhoeic piglets in The Netherlands an Switzerland. FEMS Immunol. Med. Microbiol. 1999, 24, 325-332.
• 25. Manteca C., Daube G., Jeuniaux T., Linden A., Pirson V., Detilleux J., Ginter A., Coppe P., Kaeckenbeeck A., Mainil J. G.: A role for the Clostridioum perfringens β2 toxin in bovine enterotoxaemia? Vet. Microbiol. 2002, 86, 191-202.
• 26. Ohtani K., Kawsar H. I., Okumura K., Hayashi H., Shimizu T.: The VirR/VirS regulatory cascade affects transcription of plasmid-encoded putative virulence genes in Clostridium perfringens strain 13. FEMS Microbiol. Lett. 2003, 222, 137-141.
• 27. Petit L., Gibert M., Popoff M. R.: Clostridium perfringens: toxinotype and genotype. Trends Microbiol. 1999, 7, s. 104-110.
• 28. Schmidt A. S., Angen Q., Jorsal S. E., Møller C.: Prevalence of Beta 2 producing Clostridium perfringens and Clostridium difficile among danish piglets - a case study. Proc. 18th IPVS Congress, Hamburg 2004, t. 1, s. 330.
• 29. Schotte U., Truyen U., Neubauer H.: Significance of β2-toxigenic Clostridium perfringens infections in animals and their predisposing factors. J. Vet. Med. B 2004, 51, 423-426.
• 30. Shimizu T., Ohshima T., Ohtani K., Shimizu T., Hayashi H.: Genomic map of Clostridium perfringens strain 13. Microbiol. Immunol. 2001, 45, 179-189.
• 31. Shimizu T., Yaguchi H., Ohtani K., Banu S., Hayashi H.: Clostridial VirR/VirS regulon involves a regulatory RNA molecule for expression of toxins. Mol. Microbiol. 2002, 43, 257-265.
• 32. Smedley J. G., Fisher D. J., Sayeed S., Chakrabarti G., McClane B. A.: The enteric toxins of Clostridium perfringens. Rev. of Physiol. Biochem. Pharmacol. 2004, 152, 183-204.
• 33. Songer J. G.: Clostridial enteric diseases of domestic animals. Clin. Microbial. Rev. 1996, 9, 216-234.
• 34. Songer J. G., Taylor D. W.: Clostridial infections, [w:] Straw B., Zimmerman J., D'Allaire S., Taylor D. J. (wyd.): Diseases of Swine, wyd. 9. Blackwell Publishing, Ames, Iowa USA 2006, 613-627.
• 35. Thiede S., Goethe R., Amtsberg G.: Prevalence of β2 toxin gene of Clostridium perfringens type A from diarrhoeic dogs. Vet. Rec. 2001, 149, 273-274.
• 36. Tillotson K., Traub-Dargetz J. L., Dickinson C. E., Ellis R. P., Morley P. S., Hyatt D. R., Magnuson R. J., Riddle W. T., Bolte D., Salman M. D.: Population-based study of fecal shedding of Clostridium perfringens in broodmaters and foals. J. Am. Vet. Med. Assoc. 2002, 220, 342-348.
• 37. Vilei E. M., Schlatter I., Perreten V., Straub R., Popoff M. R., Gibert M., Gröne A., Frey J.: Antibiotic-induced expression of cryptic cpb2 gene in equine β2-toxigenic Clostridium perfringens. Mol. Microbiol. 2005, 57, 1570-1581.
• 38. Wasiński B., Pejsak Z.: Cechy fenotypowe i genotypowe szczepów Clostridium perfringens izolowanych od ssących prosiąt. Medycyna Wet. 2008, w druku.
• 39. Waters M., Raju D., Garmory H. S., Popoff M. R., Sarker M. R.: Regulated expression of the Beta 2-toxin gene (cpb2) in Clostridium perfringens type A isolates from horses with gastrointsestinal diseases. J. Clin. Microbiol. 2005, 43, 4002-4009.