Do the asymmetry and the size of the structures of the temporal lobe persist in early stages of schizophrenia?

• Autorzy: Morys J M , Dziewiatkowski J. , Bobek-Billewicz B. , Ratajczak I. , Narkiewicz O. , Morys J.
• Języki publikacji: EN

Abstrakty

EN

A total of 14 patients of various ages diagnosed with schizophrenia and, as an age-matched control group, 12 healthy subjects were examined using the MRI method of neuro-imaging. The volume of the following structures was evaluated in the right and left hemispheres: the superior temporal gyrus, the basolateral temporal area (the region including the middle temporal gyrus, inferior temporal gyrus and fusiform gyrus), the parahippocampal gyrus, the hippocampal head, the amygdaloid body and the inferior horn of the lateral ventricle. In schizophrenia a significant increase in the volume of the amygdaloid body on both the left and right sides was observed. In the patients, as in the control group, we noticed significant asymmetry between the left and right sides in the volume of the structures studied. The left amygdaloid body was significantly larger than the right, whereas the left hippocampal head and the temporal horn of the lateral ventricle were smaller than the right. Our findings suggest that in the early stages of schizophrenia, despite the increased volume of the amygdaloid body, the asymmetry between the structures of the temporal lobe is still present. However, the changes observed in the temporal lobe could be related to the functional disturbances observed in this disease.

Słowa kluczowe

EN

human disease; structure; schizophrenia; asymmetry; neurobiology; temporal lobe; magnetic resonance imaging; size; early stage

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2004
• Tom: 63
• Numer: 4
• Opis fizyczny: p.401-405,fig.,ref.

Twórcy

autor

Morys J M

• Medical University, Debinki 1, 80-210 Gdansk, Poland

autor

Dziewiatkowski J.

autor

Bobek-Billewicz B.

autor

Ratajczak I.

autor

Narkiewicz O.

autor

Morys J.

Bibliografia

• 1. Andreasen NC, Ehrhardt JC, Swayze VW, Alliger RJ, Yuh WT, Cohen G, Ziebell S (1990) Magnetic resonance imaging of the brain in schizophrenia. The pathophysiologic significance of structural abnormalities. Arch Gen Psychiatry, 47: 35–44.
• 2. Barta PE, Pearlson GD, Powers RE, Richards SS, Tune LE (1990) Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. Am J Psychiatry, 147: 1457–1462.
• 3. Barta PE, Powers RE, Aylward EH, Chase GA, Harris GJ, Rabins PV, Tune LE, Pearlson GD (1997) Quantitative MRI volume changes in late onset schizophrenia and Alzheimer’s disease compared to normal controls. Psychiatry Res Neuroimaging, 68: 65–75.
• 4. Bogerts B, Falkai P, Haupts M, Greve B, Ernst S, Tapernon-Franz U, Heinzmann U (1990) Post-mortem volume measurements of limbic system and basal ganglia structures in chronic schizophrenics. Initial results from a new brain collection. Schizophr Res, 3: 295–301.
• 5. Bogerts B, Lieberman JA, Ashtari M, Bilder RM, Degreef G, Lerner G, Johns C, Masiar S (1993) Hippocampus-amygdala volumes and psychopathology in chronic schizophrenia. Biol Psychiatry, 33: 236–246.
• 6. Bogerts B, Meertz E, Schonfeldt-Bausch R (1985) Basal ganglia and limbic system pathology in schizophrenia. A morphometric study of brain volume and shrinkage. Arch Gen Psychiatry, 42: 784–790.
• 7. Breier A, Buchanan RW, Elkashef A, Munson RC, Kirkpatrick B, Gellad F (1992) Brain morphology and schizophrenia. A magnetic resonance imaging study of limbic, prefrontal cortex, and caudate structures. Arch Gen Psychiatry, 49: 921–926.
• 8. Brown R, Colter N, Corsellis JAN, Crow TJ, Frith CD, Jagoe R, Johnstone EC, Marsh L (1986) Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorders. Arch Gen Psychiatry, 43: 36–42.
• 9. Cannon TD (1996) Abnormalities of brain structure and function in schizophrenia: Implications for aetiology and pathophysiology. Ann Med, 28: 533–539.
• 10. Dąbrowski S (1994) Międzynarodowa Statystyczna Klasyfikacja Chorób i Problemów Zdrowotnych. Rewizja dziesiąta. Klasyfikacja zaburzeń psychicznych i zaburzeń zachowania w ICD-10. Badawcze kryteria diagnostyczne. Uniwersyteckie Wydawnictwo Medyczne „Vesalius”. Instytut Psychiatrii i Neurologii.
• 11. Degreef G, Ashtari M, Bogerts B, Bilder RM, Jody DN, Alvir JMJ, Lieberman JA (1992) Volumes of ventricular system subdivisions measured from magnetic resonance images in first-episode schizophrenic patients. Arch Gen Psychiatry, 49: 531–537.
• 12. DeLisi LE (1999) Defining the course of brain structural change and plasticity in schizophrenia. Psychiatry Res Neuroimaging, 92: 1–9.
• 13. DeLisi LE (1999) Volume of parahippocampal gyrus and hippocampus in schizophrenia — Author’s reply. Br J Psychiatry, 175: 388–389.
• 14. DeLisi LE, Hoff AL, Schwartz JE, Shields GW, Halthore SN, Gupta SM, Henn FA, Anand AK (1991) Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study [published erratum appears in Biol Psychiatry. 29: 159–175.
• 15. DeLisi LE, Sakuma M, Tew W, Kushner M, Hoff AL, Grimson R (1997) Schizophrenia as a chronic active brain process: A study of progressive brain structural change subsequent to the onset of schizophrenia. Psychiatry Res Neuroimaging, 74: 129–140.
• 16. Geinisman Y, Gundersen HJG, Van Der Zee E, West MJ (1996) Unbiased stereological estimation of the total number of synapses in a brain region. J Neurocytol, 25: 805–819.
• 17. Jeste DV, Lohr JB (1989) Hippocampal pathologic findings in schizophrenia. A morphometric study. Arch Gen Psychiatry, 46: 1019–1024.
• 18. Johnstone EC, Crow TJ, Frith CD, Husband J, Kreel L (1976) Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet, 2: 924–926.
• 19. Kelsoe JR, Cadet JL, Pickar D, Weinberger DR (1988) Quantitative neuroanatomy in schizophrenia. A controlled magnetic resonance imaging study. Arch Gen Psychiatry, 45: 533–541.
• 20. Keshavan MS, Schooler NR, Sweeney JA, Haas GL, Pettegrew JW (1998) Research and treatment strategies in first-episode psychoses. The Pittsburgh experience. Br J Psychiatry Suppl, 172: 60–65.
• 21. Kovelman JA, Scheibel AB (1984) A neurohistological correlate of schizophrenia. Biol Psychiatry, 19: 1601–1621.
• 22. McNeil TF, Cantor-Graae E, Weinberger DR (2000) Relationship of obstetric complications and differences in size of brain structures in monozygotic twin pairs discordant for schizophrenia. Am J Psychiatry, 157: 203–212.
• 23. Pearlson GD, Barta PE, Powers RE, Menon RR, Richards SS, Aylward EH, Federman EB, Chase GA, Petty RG, Tien AY (1997) Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biol Psychiatry, 41: 1–14.
• 24. Rajarethinam R, DeQuardo JR, Miedler J, Arndt S, Kirbat R, Brunberg JA, Tandon R (2001) Hippocampus and amygdala in schizophrenia: assessment of the relationship of neuroanatomy to psychopathology. Psychiatry Res Neuroimaging, 108: 79–87.
• 25. Razi K, Greene KP, Sakuma M, Ge SM, Kushner M, DeLisi LE (1999) Reduction of the parahippocampal gyrus and the hippocampus in patients with chronic schizophrenia. Br J Psychiatry, 174: 512–519.
• 26. Sanfilipo M, Lafargue T, Arena L, Rusinek H, Kushner K, Lautin A, Loneragan C, Vaid G, Rotrosen J, Wolkin A (2000) Fine volumetric analysis of the cerebral ventricular system in schizophrenia: Further evidence for multifocal mild to moderate enlargement. Schizophr Bull, 26: 201–216.
• 27. Shenton ME, Dickey CC, Frumin M, McCarley RW (2001) A review of MRI findings in schizophrenia. Schizophr Res, 49: 1–52.
• 28. Shenton ME, Gerig G, McCarley RW, Székely G, Kikinis R (2002) Amygdala-hippocampal shape differences in schizophrenia: the application of 3D shape models to volumetric MR data. Psychiatry Res Neuroimaging, 115: 15–35.
• 29. Shenton ME, Kikinis R, Jolesz FA, Pollak SD, LeMay M, Wible CG, Hokama H, Martin J, Metcalf D, Coleman M, McCarley RW (1992) Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N Engl J Med, 327: 604–612.
• 30. Sowell ER, Levitt J, Thompson PM, Holmes CJ, Blanton RE, Kornsand DS, Caplan R, McCracken J, Asarnow R, Toga AW (2000) Brain abnormalities in early-onset schizophrenia spectrum disorder observed with statistical parametric mapping of structural magnetic resonance images. Am J Psychiatry, 157: 1475–1484.
• 31. Sowell ER, Toga AW, Asarnow R (2000) Brain abnormalities observed in childhood-onset schizophrenia: A review of the structural magnetic resonance imaging literature. Ment Retard Dev Disabil Res Rev, 6: 180–185.
• 32. Stefanis N, Frangou S, Yakeley J, Sharma T, O’Connell P, Morgan K, Sigmudsson T, Taylor M, Murray R (1999) Hippocampal volume reduction in schizophrenia: Effects of genetic risk and pregnancy and birth complications. Biol Psychiatry, 46: 697–702.
• 33. Thune JJ, Pakkenberg B (2000) Stereological studies of the schizophrenic brain. Brain Res Rev, 31: 200–204.
• 34. Woods BT, Yurgelun-Todd D, Goldstein JM, Seidman LJ, Tsuang MT (1996) MRI brain abnormalities in chronic schizophrenia: One process or more? Biol Psychiatry, 40: 585–596.